Detection of telomere length and oxidative stress in Chondrichthyes

Hori, Misaki; Kimura, Susumu; Mizutani, Yuichi; Miyagawa, Yoshimi; Ito, Konomi; Arai, Nobuaki; Niizuma, Yasuaki

doi:10.1007/s12562-022-01633-x

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Os Mediates Telomere Length Reduction1

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2024

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“…The shortening of telomeres as cells proliferate is considered an important marker of cellular senescence or apoptosis. Studies have demonstrated a close association between OS and telomere length [49].…”

Section: Os Mediates Telomere Length Reductionmentioning

confidence: 99%

Progress in Understanding Oxidative Stress, Aging, and Aging-Related Diseases

Yang,

Luo,

Tian

et al. 2024

Antioxidants

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Under normal physiological conditions, reactive oxygen species (ROS) are produced through redox reactions as byproducts of respiratory and metabolic activities. However, due to various endogenous and exogenous factors, the body may produce excessive ROS, which leads to oxidative stress (OS). Numerous studies have shown that OS causes a variety of pathological changes in cells, including mitochondrial dysfunction, DNA damage, telomere shortening, lipid peroxidation, and protein oxidative modification, all of which can trigger apoptosis and senescence. OS also induces a variety of aging-related diseases, such as retinal disease, neurodegenerative disease, osteoarthritis, cardiovascular diseases, cancer, ovarian disease, and prostate disease. In this review, we aim to introduce the multiple internal and external triggers that mediate ROS levels in rodents and humans as well as the relationship between OS, aging, and aging-related diseases. Finally, we present a statistical analysis of effective antioxidant measures currently being developed and applied in the field of aging research.

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Section: Os Mediates Telomere Length Reductionmentioning

confidence: 99%