Detection of telomerase activity in gastric cancer

Svinareva, L. V.; Глухов, А.И.; Zimnik, O.V.; Быков, И И; Хоробрых, Т В; Швец, В. И.

doi:10.18097/pbmc20105605602

Cited by 2 publications

(1 citation statement)

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“…The expression of telomerase in cancer cells is related with their prolonged survival. This biomarker has been studied as serum parameter in multiple diseases [ 41 – 44 , 53 ]. We are reviewing the most important assays supporting its utility as urinary biomarker of bladder cancer.…”

Section: Telomerase As Cancer Marker: Urine Biomarkermentioning

confidence: 99%

Urine Telomerase for Diagnosis and Surveillance of Bladder Cancer

Lamarca

Barriuso²

2012

Advances in Urology

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Bladder cancer has increased incidence during last decades. For those patients with nonmuscle involved tumors, noninvasive diagnosis test and surveillance methods must be designed to avoid current cystoscopies that nowadays are done regularly in a lot of patients. Novel urine biomarkers have been developed during last years. Telomerase is important in cancer biology, improving the division capacity of cancer cells. Even urinary telomerase could be a potentially useful urinary tumor marker; its use for diagnosis of asymptomatic and symptomatic patients or its impact during surveillance is still unknown. Moreover, there will need to be uniformity and standardization in the assays before it can become useful in clinical practice. It does not seem to exist a real difference between the most classical assays for the detection of urine telomerase (TRAP and hTERT). However, the new detection methods with modified TeloTAGGG telomerase or with gold nanoparticles must also be taken into consideration for the correct development of this diagnosis method. Maybe the target population would be the high-risk groups within screening programs. To date there is no enough evidence to use it alone and to eliminate cystoscopies from the diagnosis and surveillance of these patients. The combination with cytology or FISH is still preferred.

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Section: Telomerase As Cancer Marker: Urine Biomarkermentioning

confidence: 99%