1995
DOI: 10.1159/000163940
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Detection of T Cell Receptors in Early Rheumatoid Arthritis Synovial Tissue

Abstract: Synovial tissue is rarely available from patients with early synovitis, with the exception of synovial biopsies. However, T cell populations early in the development of synovitis may be enriched in antigen-specific cells and critical to disease pathogenesis. To investigate the T cell repertoire in early synovitis, we utilized a PCR protocol for detection of T cell receptor (TCR) transcripts present in small amounts of synovial tissue. To expand the substrate for PCR, preamplification of cDNA was performed with… Show more

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Cited by 7 publications
(3 citation statements)
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References 27 publications
(52 reference statements)
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“…R heumatoid arthritis (RA) 4 is a chronic inflammatory joint disease of unknown etiology characterized by hyperplasia of the synovial membrane, degradation of cartilage, and bone erosion. Overexpression of proinflammatory cytokines such as IL-1 and TNF-␣ is considered to drive the destructive processes, but the causes for this disregulated cytokine production are unknown.…”
Section: Characterization Of Autoreactive T Cells To the Autoantigensmentioning
confidence: 99%
See 1 more Smart Citation
“…R heumatoid arthritis (RA) 4 is a chronic inflammatory joint disease of unknown etiology characterized by hyperplasia of the synovial membrane, degradation of cartilage, and bone erosion. Overexpression of proinflammatory cytokines such as IL-1 and TNF-␣ is considered to drive the destructive processes, but the causes for this disregulated cytokine production are unknown.…”
Section: Characterization Of Autoreactive T Cells To the Autoantigensmentioning
confidence: 99%
“…Already in early disease stages the inflamed rheumatoid synovial membrane is characterized by massive infiltration of T cells and other immune cells including B cells, macrophages, and mast cells (3)(4)(5). The majority of synovial T cells are CD4 ϩ memory cells that typically express activation markers such as HLA-DR, CD69, or CD40L but, remarkably, may be deficient in CD28 expression (6).…”
Section: Characterization Of Autoreactive T Cells To the Autoantigensmentioning
confidence: 99%
“…Furthermore, activated synovial T cells from patients with rheumatoid arthritis can induce the production of cartilage-degrading enzymes such as collagenase from dermal fibroblasts via mechanisms involving direct cell-cell contact [10]. However, the idea that the disease is driven by a particular subpopulation of T cells with restricted expression of TCR variable i gene segments which are localized to the inflamed synovium is still subject to debate [11,12]. The lines of evidence which support T-cell involvement in the aetiology of multiple sclerosis and psoriasis are similar, i.e.…”
Section: T-lymphocyte Proliferation In Autoimmune Diseasementioning
confidence: 99%