Detection of SV40 DNA sequences in malignant mesothelioma specimens from the United States, but not from Turkey

Rienzo, Assunta De; Tor, Meltem; Sterman, Daniel H.; Aksoy, Ferda; Albelda, Steven Μ.; Testa, Joseph R.

doi:10.1002/jcb.10058.abs

Cited by 8 publications

(11 citation statements)

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“…Our data reveal that erionite fibers have higher intrinsic transformation ability than asbestos fibers and give a possible explanation for the high incidence of MM in 3 small villages in Turkey, where SV40 virus infection of MM cells has never been detected 3, 4, 25, 26…”

mentioning

confidence: 73%

Erionite and asbestos differently cause transformation of human mesothelial cells

Bertino

Marconi²,

Palumbo³

et al. 2007

Intl Journal of Cancer

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Malignant mesothelioma (MM) is an aggressive tumor associated with environmental or occupational exposure to asbestos fibers. Erionite is a fibrous zeolite, morphologically similar to asbestos and it is assumed to be even more carcinogenic. Onset and progression of MM has been suggested as the result of the cooperation between asbestos and other cofactors, such as SV40 virus infection. Nevertheless, several cases of MM were associated with environmental exposure to erionite in Turkey, where SV40 was never isolated in MM specimens. We show here that erionite is poorly cytotoxic, induces proliferating signals and high growth rate in human mesothelial cells (HMC). Long term exposure to erionite, but not to asbestos fibers, transforms HMC in vitro, regardless of the presence of SV40 sequences, leading to foci formation in cultured monolayers. Cells derived from foci display constitutive activation of Akt, NF-jB and Erk1/2, show prolonged survival and a deregulated cell cycle, involving cyclin D1 and E overexpression. Our results reveal that erionite is able per se to turn HMC into transformed highly proliferating cells and disclose the carcinogenic properties of erionite, prompting for a careful evaluation of environmental exposure to these fibers. The genetic predisposition to the effect of erionite is a separate subject for investigation. ' 2007 Wiley-Liss, Inc.

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mentioning

confidence: 73%

Erionite and asbestos differently cause transformation of human mesothelial cells

Bertino

Marconi²,

Palumbo³

et al. 2007

Intl Journal of Cancer

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“…Therefore, within this hypothetical cocarcinogen framework, it is possible that upon inhalation of asbestos fibers and over an extended latency period, the immune response is impaired, and SV40-transformed mesothelial cells are afforded the opportunity to grow in an environment shielded from immune detection [44,88]. A few reports have been unable to observe SV40 sequences in MPM in countries such as Finland, Turkey and Austria [89][90][91][92]. These findings seem to fall in line with the geographic distribution of poliovirus vaccines since the inhabitants of these latter countries did not receive the SV40-contaminated version.…”

Section: Malignant Mesotheliomamentioning

confidence: 99%

SV40 association with human malignancies and mechanisms of tumor immunity by large tumor antigen

Lowe

Shearer

Jumper

et al. 2007

Cell. Mol. Life Sci.

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SV40 was discovered as a contaminate of poliovirus vaccine lots distributed to millions of individuals in the United States between 1955 and 1963 while contaminated vaccine batches were later circulated worldwide. After SV40 was observed to cause in vitro animal and human cell transformations and in vivo tumor formations in animals, the search for a connection between the virus and human malignancies has continued to the present day. Different molecular methods have been used to detect SV40 gene products in a variety of human cancers, though SV40 causality in these tumor types has yet to be established. These data, however, are not without controversial issues related to inconclusive SV40 serological and epidemiological evidence alongside tools and methodologies that may contribute to false-positive results in human specimens. This review will also explore how vaccination against SV40 protein products may be used to help prevent and treat individuals with SV40-expressing cancers.

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“…[10][11][12][13] Various studies have reported that male gender, age >75 years, cigarette smoking, leukocyte count >8400 mm 3 , serum LDH level > 500 U/L, advanced stage disease, and Karnofsky performance scale < 70 are signs of poor prognosis. [10][11][12][13] Various studies have reported that male gender, age >75 years, cigarette smoking, leukocyte count >8400 mm 3 , serum LDH level > 500 U/L, advanced stage disease, and Karnofsky performance scale < 70 are signs of poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

Relation between neutrophil/lymphocyte ratio and primary tumor metabolic activity in patients with malign pleural mesothelioma

Özyürek

Özmen

Özdemirel

et al. 2016

Clinical Respiratory J

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The aim of this study was to evaluate the relationship of the pre-treatment blood neutrophil/lymphocyte count ratio (NLR) with the maximum standard uptake value (SUVmax) of primary masses on positron emission tomography/computed tomography (PET/CT) taken before treatment in patients diagnosed with malignant pleural mesothelioma (MPM) and to evaluate the contribution to prognosis. A retrospective evaluation was made of 73 patients diagnosed with MPM in our hospital between January 2006 and January 2014. The SUVmax value of the primary mass on pre-treatment PET/CT, the haemogram parameters (Hb, Hct, NLR, MPV, PLT) at the time of diagnosis, the progression history, the date of the final visit, and the date of death of exitus patients was recorded from patient files PET/CT. The study group comprised 37 males (50.7%) with a mean age of 56.1 ± 11.4 years. The median survival time of these patients was 13 months. The survival time of the patient group aged <55 years was significantly longer (P = .006). Although the survival time of patients with NLR < 3 and SUVmax < 5 was longer, the difference was not statistically significant (P = .63, P = 0.08). A statistically significant difference was determined between the mean (or median) SUVmax values of the patient groups with NLR < 3 and NLR ≥3 (P = .019) with the SUVmax value of the NLR < 3 group found to be low. In conclusion, in patients with MPM, NLR ≥3 and high SUVmax values at the time of diagnosis can be considered an indicator of poor prognosis but are not a guide in the prediction of progression.

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Detection of SV40 DNA sequences in malignant mesothelioma specimens from the United States, but not from Turkey

Cited by 8 publications

References 0 publications

Erionite and asbestos differently cause transformation of human mesothelial cells

Erionite and asbestos differently cause transformation of human mesothelial cells

SV40 association with human malignancies and mechanisms of tumor immunity by large tumor antigen

Relation between neutrophil/lymphocyte ratio and primary tumor metabolic activity in patients with malign pleural mesothelioma

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