Detection of spirochetal micro-organisms by focus-floating microscopy in necrobiotic xanthogranuloma

Zelger, Bernhard; Eisendle, Klaus; Mensing, Christian; Zelger, Bettina

doi:10.1016/j.jaad.2007.05.016

Cited by 59 publications

(37 citation statements)

References 24 publications

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“…On the contrary, M-protein may be the primary abnormality, and skin lesions arise from secondary proliferation of macrophages bearing receptors for Fc portion of their M-protein [4]. Another study identified spirochaetal organism in NXG lesions, suggesting infectious etiology of NXG [5]. Immunohistochemical analysis of 11 cases of NXG showed a polytypic staining pattern in the inflammatory cells and the number of the IgG4 plasma cells was not increased, suggesting that the skin lesions represent reactive inflammation [6].…”

Section: Discussionmentioning

confidence: 99%

Periorbital necrobiotic xanthogranuloma without paraproteinemia

Nakamura-Wakatsuki¹,

Yamamoto²

2013

Our Dermatol Online

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Introduction: Necrobiotic xanthogranuloma (NXG) is a rare histiocytic disease which most frequently involves periorbital areas. NXG is associated with paraproteinemia with a ratio over 80%. However, a few cases of NXG without paraproteinemia (isolated NXG) have also been reported. Main observation: A 58-year-old Japanese woman complained about asymptomatic dermal nodules on the bilateral lower eyelids. The histopathological examination revealed granulomatous inflammation. Paraproteinemia was not detected either in the serum or in the urine. The size of the nodules has been constant, and she has been under careful follow-up without any systemic therapies. Conclusions: NXG is frequently associated with paraproteinemia, which may develop later. Patients with NXG need careful follow-up including repeated blood tests.

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Section: Discussionmentioning

confidence: 99%

Periorbital necrobiotic xanthogranuloma without paraproteinemia

Nakamura-Wakatsuki¹,

Yamamoto²

2013

Our Dermatol Online

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“…oftalmolojik komplikasyonlar görülür 24 . Patogenez ile ilgili bilgiler sınırlıdır ancak Zelger ve arkadaşlarının yapmış oldukları histopatolojik çalışmada Borrelia cinsi spiroketlerin gösterilmesi, NKG gelişiminde spiroketlerin rolü olabileceğini düşündürmüştür 25 . NKG'lu olgularda yapılan araştırmalar sonucunda hastaların %80'inde sıklıkla IgG kappa nadiren de IgA tipinde monoklonal gammopati saptanır 26 .…”

Section: Nekrobiyotik Ksantogranülomunclassified

Paraneoplastik özellik gösteren metabolik hastalıklar

Aydıngöz¹,

Akkaya²

2013

TURKDERM

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“…Indeed, evidence is growing that granuloma annulare [97][98][99][100][101][102][103][104] and interstitial granulomatous dermatitis [105][106][107] might be partly caused by B. burgdorferi or similar strains. There are single reports that connect other skin disease to Borrelia, for example, cutaneous sarcoidosis, especially in the Chinese literature [108][109][110][111][112][113][114][115][116][117][118][119][120], necrobiosis lipoidica [121], necrobiotic xanthogranuloma [122] and single cases of mycosis fungoides [123], but the evidence for latter skin disease is not unambiguous. In addition, as the modern chameleon of dermatology, cutaneous borreliosis, especially BL, mimics other skin conditions, as has been shown for erythema annulare centrifugum or lymphocytic infiltration of the skin (Jessner-Kanof) [124][125][126][127][128][129].…”

Section: Reviewmentioning

confidence: 99%

“…Cases of cutaneous T-cell-lymphoma (mycosis fungoides) [123] Erythema annulare centrifugum [129] Necrobiosis lipoidica [121] Necrobiotic xanthogranuloma [122] The skin diseases are subdivided to low/medium, medium/high and definitive/proven borrelial association. Review disease or neuroborreliosis [135,136].…”

Section: Possible Association (Single Reports) With Borrelia Infectionmentioning

confidence: 99%