Detection of sonoluminescence signals in a gel phantom in the presence of Protoporphyrin IX conjugated to gold nanoparticles

Sazgarnia, Ameneh; Shanei, Ahmad; Eshghi, Hossein; Hassanzadeh-Khayyat, Mohammad; Esmaily, Habibollah; Shanei, Mohammad Mahdi

doi:10.1016/j.ultras.2012.03.009

Cited by 50 publications

(36 citation statements)

References 21 publications

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“…Moreover, Sazgarnia et al [133] succeeded in detecting SL in gel-based phantoms using protoporphyrin IX coupled to gold NPs and thus showing that SL is effectively generated during SDT.…”

Section: Cytotoxic Effects Arising From Nanoparticle-activation By Camentioning

confidence: 99%

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Canavese

Ancona

Racca

et al. 2018

Chemical Engineering Journal

322

247

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• Ultrasound-based therapies are opening new horizons in the oncological field.• Innovative and promising solutions derive from different nanoparticles-assisted ultrasound treatments.• Sonodynamic therapy (SDT) emerged recently as a novel approach for cancer treatment.• Different and complex cell death mechanisms are involved in nanoparticles-assisted SDT.• Nanoparticles-assisted ultrasound is still at its infancy in clinics. A R T I C L E I N F O Keywords:Inertial cavitation Reactive oxygen species Sonoluminescence Sonodynamic Tumor Therapy Cytotoxicity A B S T R A C TAt present, ultrasound radiation is broadly employed in medicine for both diagnostic and therapeutic purposes at various frequencies and intensities. In this review article, we focus on therapeutically-active nanoparticles (NPs) when stimulated by ultrasound. We first introduce the different ultrasound-based therapies with special attention to the techniques involved in the oncological field, then we summarize the different NPs used, ranging from soft materials, like liposomes or micro/nano-bubbles, to metal and metal oxide NPs. We therefore focus on the sonodynamic therapy and on the possible working mechanisms under debate of NPs-assisted sonodynamic treatments. We support the idea that various, complex and synergistics physical-chemical processes take place during acoustic cavitation and NP activation. Different mechanisms are therefore responsible for the final cancer cell death and strongly depends not only on the type and structure of NPs or nanocarriers, but also on the way they interact with the ultrasonic pressure waves. We conclude with a brief overview of the clinical applications of the various ultrasound therapies and the related use of NPs-assisted ultrasound in clinics, showing that this very innovative and promising approach is however still at its infancy in the clinical cancer treatment.

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“…Moreover, Sazgarnia et al [133] succeeded in detecting SL in gel-based phantoms using protoporphyrin IX coupled to gold NPs and thus showing that SL is effectively generated during SDT.…”

Section: Cytotoxic Effects Arising From Nanoparticle-activation By Camentioning

confidence: 99%

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Canavese

Ancona

Racca

et al. 2018

Chemical Engineering Journal

322

247

View full text Add to dashboard Cite

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“…For some researchers, acoustic cavitation is an extreme phenomenon that is responsible for generating excessive vibration, erosion, reduced hydraulic performance and structural damage [22], while, for others, it is seen as an enormous concentration of energy with a wide range of unexplored chemical and physical consequences [23,24]. In particular, the emission of SL [25][26][27] has been proposed as the pivotal trigger for the sonosensitiser-mediated generation of reactive oxygen species (ROS) in SDT [28,29]. This hypothesis was formulated because most of the chemical compounds used in SDT are also photosensitisers [14].…”

Section: Introductionmentioning

confidence: 99%

Insight into ultrasound-mediated reactive oxygen species generation by various metal-porphyrin complexes

Giuntini

Foglietta

Marucco

et al. 2018

Free Radical Biology and Medicine

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Ultrasound is used to trigger the cytotoxicity of chemical compounds, known as sonosensitisers, in an approach called sonodynamic therapy (SDT), which is under investigation herein. The generation of reactive oxygen species (ROS) has been proposed as the main biological occurrence that leads to the cytotoxic effects, which are achieved via the synergistic action of two components: the energy-absorbing sonosensitiser and ultrasound (US), which are both harmless per se. Despite some promising results, a lack of investigation into the mechanisms behind US sonosensitiser-mediated ROS generation has prevented SDT from reaching its full potential. The aim of this work is to investigate the US-responsiveness of a variety of metal-porphyrin complexes, free-base porphyrin and Fe(III), Zn(II) and Pd(II) porphyrin, by analyzing their ROS generation under US exposure and related bio-effects. All experiments were also carried out under light exposure and the results were used as references. Our results show that porphyrin ultrasound-responsiveness depends on the metal ion present, with Zn(II) and Pd(II) porphyrin being the most efficient in generating singlet oxygen and hydroxyl radicals. ROS production efficiency is lower after ultrasound exposure than after light exposure, because of the various physico-chemical mechanisms involved in sensitiser activation. US and porphyrin-mediated ROS generation is oxygen-dependent and the activation of porphyrin by US appears to be more compatible with sonoluminescence-based photo-activation rather than a radical path process that occurs via the homolytic bond rupture of water. Notably, the cytotoxicity results reported herein, which are mirrored by ex-cellulo data, confirm that the type of ROS generation achieved by the US activation of intracellular porphyrins is pivotal to the effectiveness of cancer cell killing.

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“…However, internal cavitation is difficult to control. To overcome such limitation, researchers have been using AuNMs as agents to lower the threshold of cavitation intensity, acting both as cavitation nuclei and promoting the collapse of the microbubbles [49,51,[129][130][131][132][133][134][135]. Also, AuNMs aggregation, which induces thermal field overlap and plasmonic coupling, has been investigated as a method to further lower the required fluence levels [136].…”

Section: High-intensity Focused Ultrasound Therapy (Hifu)mentioning

confidence: 99%

Latest advances in combining gold nanomaterials with physical stimuli towards new responsive therapeutic and diagnostic strategies

Movia

Benhaddada

Spadavecchia

et al. 2020

Precision Nanomedicine

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Graphical abstract KeywordsGold nanoparticle 1 ; external stimuli; physical stimuli; physically triggered nanomedicine. Quote this article as: Movia D, Benhaddada M, Jolanda Spadavecchia J, Prina-Mello A, Latest advances in combining gold nanomaterials with physical stimuli towards new responsive therapeutic and diagnostic strategies, Precis. Nanomed. 2020 April;3(2):495-524, https://doi. AbstractNanomedicine aims at enhancing treatment efficiency and/or improving diagnostic sensitivity by better controlling several critical parameters, such as tissue targeting and off-target toxicity. More recently, advanced nanomedicine products have been developed to achieve spatially and temporally controlled therapy and diagnosis. This review focuses on gold nanomaterials (AuNMs) and alloy/hybrid AuNMs that can be used in stimuli-responsive strategies for therapeutic and diagnostic applications. Endogenous and/or exogenous stimuli can be used as a trigger for such systems. Herein, we focus on those activated by exogenous stimuli. Our review starts from one specific externally activated product, Aurolase®, which recently underwent clinical studies. Further we continue describing a specific physically triggered category, for which the exogeneous stimulus applied induces a structural transformation or modification that is essential for their therapeutic and/or diagnostic action. Gold nanomaterials are grouped both by the nature of the function they exert (therapeutic or diagnostic) and the stimuli class.

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Detection of sonoluminescence signals in a gel phantom in the presence of Protoporphyrin IX conjugated to gold nanoparticles

Cited by 50 publications

References 21 publications

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Insight into ultrasound-mediated reactive oxygen species generation by various metal-porphyrin complexes

Latest advances in combining gold nanomaterials with physical stimuli towards new responsive therapeutic and diagnostic strategies

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