Detection of soft-tissue hyperemia: value of power Doppler sonography.

Newman, Joel S.; Adler, Ronald S.; Bude, Ronald O.; Rubin, Jonathan M.

doi:10.2214/ajr.163.2.8037037

Cited by 297 publications

(148 citation statements)

References 5 publications

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“…Previous studies in non-neoplastic diseases of muscle (Newman et al, 1994) and kidney have supported the notion that power Doppler ultrasonography facilitates the evaluation of tissue perfusion. The current applications of ultrasound in the field of oncology are limited to tumour detection and staging [for example, see (Lindmark et al, 1992)] and to aid the placement of biopsies into regions of abnormal grey scale echogenicity [for examples, see (Fomage et al, 1992;Parker et al, 1993;McCombs et al, 1995) (Alexander et al, 1996).…”

Section: Discussionmentioning

confidence: 84%

Use of power Doppler ultrasound-guided biopsies to locate regions of tumour hypoxia

Evans

Laughlin²,

Pugh³

et al. 1997

Br J Cancer

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Summary The purpose of this study was to determine whether power Doppler ultrasound techniques could be used to direct biopsies into tumour regions with relatively low red blood cell flux, and therefore preferentially sample regions that were relatively hypoxic. Subcutaneous 9L glioma rat tumours were biopsied using power Doppler ultrasound guidance. Immunohistochemical detection of the 2-nitroimidazole EF5 was performed to determine the presence and level of hypoxia in the biopsy samples. Comparisons between the power Doppler-determined red blood cell flux and EF5 binding were made. In seven out of eight tumours studied, power Doppler ultrasound allowed differentiation of a relatively hypoxic region from a relatively oxic region by localizing relatively low vs high red blood cell flux areas respectively. In one of these seven tumours, RBC flux was high in both biopsied sites and hypoxia was not present in either. In two of these seven tumours, hypoxia was present in each biopsy and both of the red blood cell flux measurements were low. In the eighth tumour, both the EF5 binding and the red blood cell flux measurements were low. In this tumour, low EF5 binding was due to the dominance of necrotic cells, which will not reduce or bind EF5 in the biopsy specimen. Using EF5-binding techniques, we have confirmed that regions of relatively low red blood cell flux are more hypoxic than those with relatively high red blood cell flux. Counterstaining specimens with haematoxylin and eosin allows differentiation of low EF5-binding regions due to oxia vs necrosis. These methods have clinical implications for the expanded use of power Doppler ultrasound as a means to direct tissue sampling when it is important to identify the presence of hypoxia.

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Section: Discussionmentioning

confidence: 84%

Use of power Doppler ultrasound-guided biopsies to locate regions of tumour hypoxia

Evans

Laughlin²,

Pugh³

et al. 1997

Br J Cancer

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“…Power Doppler sonography (PDS) enables the visualization of synovial vascularity and has the ability to represent local inflammation numerically (5). PDS has been reported as a useful tool to detect arthritis in the early stages and monitor disease activity (6,7).…”

Section: Introductionmentioning

confidence: 99%

Radiographic prognosis of finger joint damage predicted by early alteration in synovial vascularity in patients with rheumatoid arthritis: Potential utility of power doppler sonography in clinical practice

Fukae¹,

Isobe²,

Kitano³

et al. 2011

Arthritis Care & Research

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Objective. To investigate the relationship between synovial vascularity and progression of structural bone damage in each finger joint in patients with rheumatoid arthritis (RA) and to demonstrate synovial vascularity as a potential therapeutic marker. Methods. We studied 250 metacarpophalangeal (MCP) and 250 proximal interphalangeal (PIP) joints of 25 patients with active RA who were administered adalimumab or tocilizumab. Patients were examined with clinical and laboratory assessments. Power Doppler sonography was performed at baseline and at the fourth and eighth weeks. Synovial vascularity was evaluated according to quantitative measurement. Hand and foot radiography was performed at baseline and the twentieth week. Results. Clinical indices such as the 28-joint Disease Activity Score, the Clinical Disease Activity Index, and the Simplified Disease Activity Index were significantly decreased by biologic agents. The MCP and PIP joints with no response in synovial vascularity between baseline and the eighth week (vascularity improvement of <70% at the eighth week) showed a higher risk of radiographic progression compared with responsive joints (vascularity improvement of >70% at the eighth week; relative risk 2.33-9). Radiographic progression at the twentieth week was significantly lower in responsive joints than in nonresponsive joints. Conclusion. The improvement of synovial vascularity following treatment with biologic agents led to suppression of radiographic progression of RA in each finger joint. The alteration in synovial vascularity numerically reflected therapeutic efficacy. Using vascularity as a marker to determine the most suitable therapeutic approach would be beneficial for patients with active RA.

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“…Focal abnormal echogenicity was the least yielding criteria, which classified 5 tears as full thickness tears and 9 as partial thickness tears. Newman JS et al 16 reports combination of tendon in homogeneity and anisotropy are the most common cause of a falsepositive diagnosis of a partial thickness rotator cuff tear.…”

Section: Resultsmentioning

confidence: 99%

Comparative Study of Ultrasonography with MRI in Rotator Cuff Tears

Soman¹

2017

JMSCR

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Detection of soft-tissue hyperemia: value of power Doppler sonography.

Cited by 297 publications

References 5 publications

Use of power Doppler ultrasound-guided biopsies to locate regions of tumour hypoxia

Use of power Doppler ultrasound-guided biopsies to locate regions of tumour hypoxia

Radiographic prognosis of finger joint damage predicted by early alteration in synovial vascularity in patients with rheumatoid arthritis: Potential utility of power doppler sonography in clinical practice

Comparative Study of Ultrasonography with MRI in Rotator Cuff Tears

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