Detection of Small Intestine Bacterial Overgrowth by Means of a 14C-D-Xylose Breath Test

King, Charles; Toskes, Phillip P.; Spivey, John C.; Lorenz, Erhard; Welkos, Susan L.

doi:10.1016/s0016-5085(79)80013-x

Cited by 87 publications

(12 citation statements)

References 13 publications

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“…In addition, lactulose, as a substrate, does not cause blood glucose fluctuations in patients with diabetes, and it is not recommended to use glucose for detection for many pregnant women with blood glucose instability. Although XBT has high sensitivity and specificity, it may have a small amount of 14 CO 2 radioisotope release ( 17 , 18 ), which is not suitable for pregnant women. Therefore, we used the LHBT to detect SIBO.…”

Section: Discussionmentioning

confidence: 99%

Small Intestinal Bacterial Overgrowth in Subclinical Hypothyroidism of Pregnant Women

Wang

Hou

et al. 2021

Front. Endocrinol.

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ObjectiveTo evaluate the small intestinal bacterial overgrowth (SIBO) of subclinical hypothyroidism of pregnant women, and explore their possible relevance.MethodsIn total, 224 pregnant women with subclinical hypothyroidism during pregnancy (study group) and 196 pregnant women whose thyroid function was normal (control group) were enrolled in this study. Lactulose-based hydrogen and methane breath test was performed to evaluate the growth of intestinal bacteria. The serum-free thyroid hormone (FT4), thyroid-stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb), body mass index (BMI) and gastrointestinal symptoms were detected and recorded.ResultsThe positive rates of SIBO were 56.7% and 31.6% in study group and control group, respectively. The levels of C response protein (CRP), abdominal distension and constipation in study group were higher than those in the control group. The risk of abdominal distension and constipation in SIBO-positive pregnant women were higher than that in SIBO-negative pregnant women, and the BMI of SIBO-positive patients in the two groups was lower than that of SIBO-negative patients in each group. In addition, the TPOAb-positive rate and TSH levels were higher but the FT4 level was lower in SIBO-positive patients compared to SIBO-negative patients in study group.ConclusionThe occurrence of subclinical hypothyroidism is related to SIBO, and the excessive growth of small intestinal bacteria may affect gastrointestinal symptoms.Clinical Trialhttp://www.chictr.org.cn/index.aspx, identifier ChiCTR1900026326.

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Section: Discussionmentioning

confidence: 99%

Small Intestinal Bacterial Overgrowth in Subclinical Hypothyroidism of Pregnant Women

Wang

Hou

et al. 2021

Front. Endocrinol.

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“…Xylose Breath Test The method described by King et al 3 was modified for use with a scintillation counter, and the radiolabel dose was reduced. The test depends on bacterial catabolism of xylose within the lumen of the small intestine with the release of CO 2 .…”

Section: Methodsmentioning

confidence: 99%

“…The techniques used include duodenal aspiration for culture, the 14C‐glycocholate breath test, and the hydrogen breath test. A 14C‐xylose breath test was also used 3 ; this was modified in order to employ a scintillation counter to measure 14C‐labeled carbon dioxide output.…”

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confidence: 99%

The Diagnosis of Small Bowel Bacterial Overgrowth in Elderly Patients

Donald

Kitchingmam²,

Donald³

et al. 1992

J American Geriatrics Society

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“…We reached different conclusions for the two breath tests. In the study of the 13 [133][134][135][136]. As many as 10% of some populations may be non-H 2 producers [137][138][139].…”

Section: The 13 C-d-xylose Breath Test and The 13 C-sorbitol Breath Testmentioning

confidence: 99%

¹³C-xylose and¹⁴C-xylose breath tests for the diagnosis of coeliac disease

Tveito¹,

Brunborg²,

Sandvik³

et al. 2008

Scandinavian Journal of Gastroenterology

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Detection of Small Intestine Bacterial Overgrowth by Means of a 14C-D-Xylose Breath Test

Cited by 87 publications

References 13 publications

Small Intestinal Bacterial Overgrowth in Subclinical Hypothyroidism of Pregnant Women

Small Intestinal Bacterial Overgrowth in Subclinical Hypothyroidism of Pregnant Women

The Diagnosis of Small Bowel Bacterial Overgrowth in Elderly Patients

¹³C-xylose and¹⁴C-xylose breath tests for the diagnosis of coeliac disease

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Detection of Small Intestine Bacterial Overgrowth by Means of a 14C-D-Xylose Breath Test

Cited by 87 publications

References 13 publications

Small Intestinal Bacterial Overgrowth in Subclinical Hypothyroidism of Pregnant Women

Small Intestinal Bacterial Overgrowth in Subclinical Hypothyroidism of Pregnant Women

The Diagnosis of Small Bowel Bacterial Overgrowth in Elderly Patients

13C-xylose and14C-xylose breath tests for the diagnosis of coeliac disease

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¹³C-xylose and¹⁴C-xylose breath tests for the diagnosis of coeliac disease