Detection of slow growing Actinomadura species proved a key formanagement of mycetoma: A case report from Chhattisgarh

Sharma, Pratibha; Wankhade, Archana; Gaikwad, Ujjwala; Das, Padma

doi:10.4103/jfmpc.jfmpc_481_20

Cited by 2 publications

(6 citation statements)

References 10 publications

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“…empts to engulf and inac" vate the pathogens but is unable to do so producing three types of immune response. 2 Firstly, degranulated neutrophils adheres to the grain surface which is surrounded by zone of granula" on " ssue containing macrophages, lymphocytes, and plasma cells. Secondly neutrophil disappears and macrophage arrives to clear it.…”

Section: Discussionmentioning

confidence: 99%

“…In this study only genus Ac• nomadura was iden" fi ed and species could notbe iden" fi ed. 2 Ultrasound imaging is done to accurately defi ne the extent of the lesion. Presence of grains can be shown by sharp hyper-refl ec" ve echoes.…”

Section: Discussionmentioning

confidence: 99%

“…1 It is also called as "Madura foot". 2 It is localized, slowly progressing, chronic granulomatous infec! on of skin and subcutaneous !…”

Section: Introduc• Onmentioning

confidence: 99%

“…on such as thorn pricks or splinters. 1,2 In comparison to eumycetoma, ac! nomycetoma tends to progress more rapidly with extensive !…”

Section: Introduc• Onmentioning

confidence: 99%

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A Neglected Swollen Limb: Resurgence or Common Tropical Disease?

Ray

Thapa

2023

Nepal J Dermatol Venereol & Leprol

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Mycetoma is uncommon, chronic granulomatous infection caused either by fungi or by aerobic filamentous actinomycetes which is characterized by a triad of painless subcutaneous mass, multiple sinuses and discharge containing grains. We report a case of 40 years old male, farmer who presented with multiple painless swollen lesions over right foot for 8 years. Swelling had gradually increased in size over a few years followed by multiple episodes of discharge. It had not restricted his daily activities. On examination, there were multiple nodules and sinuses discharging serous fluid from the right foot. Gram staining showed gram positive filamentous rods and KOH was negative. Histopathology showed multiple granulomas. Patient was treated for 5 cycles using modified Welsh regimen with Amikacin 750mg intravenously once a day, oral Cotrimoxazole 960mg twice daily and oral Rifampicin 600mg once daily along with oral iron and folic acid supplementation continuously for 21days which constituted 1 cycle with an interval of 15 days between each cycle. Patient was assessed by measuring girth of foot and number of lesions in each visit and showed significant improvement at the end of fifth cycle. Patient was followed for 1 year after treatment without any recurrence.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

A Neglected Swollen Limb: Resurgence or Common Tropical Disease?

Ray

Thapa

2023

Nepal J Dermatol Venereol & Leprol

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“…The area lying between 15°S and 30°N is said to be the Mycetoma belt. Three countries viz., Sudan, Mexico and India are predominantly affected [1,7]. Fusarium sp.…”

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confidence: 99%

Fusarium as a Cause of Mycetoma: A Case Report and Review of the Literature

Waske¹,

Ayer²,

Marothi³

2023

NJLM

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Mycetoma is a chronic, slow progressive granulomatous infection of skin and subcutaneous tissue; is classified into Eumycetoma (caused by fungi) and Actinomycetoma (caused by Actinomycetes). Fusarium, is a known cause of mycetoma. This case report describes the isolation and identification of Fusarium sp. from a lesion on the right foot of a female patient. This case report is about a 23-year-old female with complaints of gradual enlarging nodular swelling with multiple discharging sinuses along with granules on the right foot, on and off for last seven years. The granules obtained from the lesions are the best specimen for culture as they contain microcolonies of causative agents and it’s a hallmark of mycetoma. Granules were collected aseptically, crushed and examined microscopically on 20% KOH preparation. Plenty of thin hyaline, septate hyphae were seen. Granules were washed with sterile saline and inoculated on Sabouraud’s Dextrose Agar (SDA) and potato dextrose agar and incubated aerobically at 25°C and 37°C in two sets of each. Colonies grew at inoculated site, pinkish in the centre and whitish in the periphery. The isolate was identified as Fusarium sp. on the basis of morphology. The patient was started on Itraconazole 200 mg and is currently on the same treatment, improving and under follow-up. Mycetoma is a rare disease caused by both fungal and bacterial microorganisms. Definitive diagnosis should be made on the basis of culture or histopathological examination. Once the diagnosis is made, use of appropriate anti-fungal therapy with or without surgical interventions can result in complete cure without recurrence.

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Detection of slow growing Actinomadura species proved a key formanagement of mycetoma: A case report from Chhattisgarh

Cited by 2 publications

References 10 publications

A Neglected Swollen Limb: Resurgence or Common Tropical Disease?

A Neglected Swollen Limb: Resurgence or Common Tropical Disease?

Fusarium as a Cause of Mycetoma: A Case Report and Review of the Literature

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