Detection of singlet oxygen by chemical trap in ionic liquids

Liu, Li; Zhang, Zhe; Zhao, Qingyang; Chen, Xuning; Deng, Liezheng; Chen, Wenwu; Jin, Yuqi

doi:10.1016/j.cplett.2019.136952

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…Furthermore, the usage of chemical traps allows to expand the analysis time of 1 O 2 from its original half-life of a few microseconds to a few minutes. In general, a broad variety of probes and chemical Pharmaceutics 2022, 14, 72 6 of 50 traps for 1 O 2 detection are currently available that differs in their specificity, reactivity and thermal stability [56,[62][63][64][65][66]. Consequently, one must always evaluate and choose suitable spectroscopic probes or chemical traps depending on the respective question at hand.…”

Section: Singlet Oxygen ( 1 O2)mentioning

confidence: 99%

Photo-Oxidation of Therapeutic Protein Formulations: From Radical Formation to Analytical Techniques

et al. 2021

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UV and ambient light-induced modifications and related degradation of therapeutic proteins are observed during manufacturing and storage. Therefore, to ensure product quality, protein formulations need to be analyzed with respect to photo-degradation processes and eventually protected from light exposure. This task usually demands the application and combination of various analytical methods. This review addresses analytical aspects of investigating photo-oxidation products and related mediators such as reactive oxygen species generated via UV and ambient light with well-established and novel techniques.

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Section: Singlet Oxygen ( 1 O2)mentioning

confidence: 99%

Photo-Oxidation of Therapeutic Protein Formulations: From Radical Formation to Analytical Techniques

et al. 2021

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Fluorescent chemical sensors: applications in analytical, environmental, forensic, pharmaceutical, biological, and biomedical sample measurement, and clinical diagnosis

Fakayode

Lisse

Medawala

et al. 2023

Applied Spectroscopy Reviews

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Novel Oxygen- and Curcumin-Laden Ionic Liquid@Silica Nanocapsules for Enhanced Antimicrobial Photodynamic Therapy

et al. 2023

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The efficiency of photodynamic therapy is often limited by the scarcity of oxygen at the target site. To address this problem, this work proposes the development of a new nanosystem for antimicrobial photodynamic therapy applications (aPDT) where the natural-origin photosensitizer curcumin (CUR) is immersed in an oxygen-rich environment. Inspired by the perfluorocarbon-based photosensitizer/O2 nanocarriers reported in the literature, we developed a new type of silica nanocapsule containing curcumin dissolved in three hydrophobic ionic liquids (ILs) with high oxygen dissolving capacities. The nanocapsules (CUR-IL@ncSi), prepared by an original oil-in-water microemulsion/sol-gel method, had a high IL content and exhibited clear capacities to dissolve and release significant amounts of oxygen, as demonstrated by deoxygenation/oxygenation studies. The ability of CUR-IL solutions and of CUR-IL@ncSi to generate singlet oxygen (1O2) upon irradiation was confirmed by the detection of 1O2 phosphorescence at 1275 nm. Furthermore, the enhanced capacities of oxygenated CUR-IL@ncSi suspensions to generate 1O2 upon irradiation with blue light were confirmed by an indirect spectrophotometric method. Finally, preliminary microbiological tests using CUR-IL@ncSi incorporated into gelatin films showed the occurrence of antimicrobial effects due to photodynamic inactivation, with their relative efficiencies depending on the specific IL in which curcumin was dissolved. Considering these results, CUR-IL@ncSi has the potential to be used in the future to develop biomedical products with enhanced oxygenation and aPDT capacities.

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Detection of singlet oxygen by chemical trap in ionic liquids

Cited by 3 publications

References 27 publications

Photo-Oxidation of Therapeutic Protein Formulations: From Radical Formation to Analytical Techniques

Photo-Oxidation of Therapeutic Protein Formulations: From Radical Formation to Analytical Techniques

Fluorescent chemical sensors: applications in analytical, environmental, forensic, pharmaceutical, biological, and biomedical sample measurement, and clinical diagnosis

Novel Oxygen- and Curcumin-Laden Ionic Liquid@Silica Nanocapsules for Enhanced Antimicrobial Photodynamic Therapy

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