Abstract-We report here recent work at the UK National Physical Laboratory (NPL) on developing nanoscale SQUIDs using Dayem bridge Josephson junctions. The advantages are simplicity of fabrication, exceptional low-noise performance, towards the quantum limit, and a range of novel applications. Focused ion beam patterned Nb SQUID, possessing exceptionally low noise (~200n 0/ Hz 1/2 above 1kHz), and operating above 4.2 K can be applied to measurement of nanoscale magnetic objects or coupled to nano-electromechanical (NEMS) resonators, as well as single particle detection of photons, protons and ions. The limited operating temperature range may be extended by exposing the Dayem bridges to carefully controlled ion beam implantation, leading to non-reversible changes in junction transition temperature.