Detection of serum p53 antibodies in patients with esophageal squamous cell carcinoma: correlation with clinicopathologic features and tumor markers.

Shimada, Hideaki; Nakajima, Kiyokazu; Ochiai, Takenori; Koide, Yuji; Okazumi, S.; Matsubara, Hisahiro; Takeda, Akihiko; Miyazawa, Yasumasa; Arima, Miwako; Isono, Kaichi

doi:10.3892/or.5.4.871

Cited by 18 publications

(15 citation statements)

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“…The association between elevated Ap53Ab and lymph node metastasis was consistent with previous data from an Asian population (4,5,7). In gastric cancer, an elevated Ap53Ab level tended to be associated with lymph node metastasis (21), but positive Ap53Ab expression was not found to be correlated with lymph node metastasis in esophageal squamous cell carcinoma (22). Therefore, the elevated Ap53Ab level may be consistently associated with deeper depth of invasion and lymph node metastasis in CRC, that is to say that deeper depth of invasion and lymph node metastasis may be involved in the production of Ap53Ab.…”

Section: Ap53ab Expression N (%) -----------------------------------supporting

confidence: 81%

Clinical significance of serum anti-p53 antibody expression following curative surgery for colorectal cancer

Kumamoto

Ishida

Kuwabara

et al. 2017

Molecular and Clinical Oncology

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Abstract. The aim of the present study was to investigate the usefulness of serum anti-p53 antibody (Ap53Ab) measurement for the diagnosis of colorectal cancer (CRC), and the clinical significance of the association between Ap53Ab expression and survival rate. Ap53Ab, carcinoembryonic antigen (CEA) and carbohydrate antigen (CA)19-9 were measured by ELISA in 674 CRC patients and 115 healthy volunteers (control group). The half-life time of Ap53Ab and CEA was calculated. The association between positive Ap53Ab expression and clinicopathological characteristics, including survival rate, was analyzed. Of the 674 CRC patients, 195 (28.9%) were positive for Ap53Ab expression, while the positive rates of CEA and CA19-9 level were 39.9 and 16.9%, respectively. Positivity for Ap53Ab alone was observed in 94 patients (13.9%), whereas the positivity rate of any markers examined was 58.7%. The mean half-life of Ap53Ab and CEA was 30.7 and 11.3 days, respectively. Positive expression of Ap53Ab was significantly associated with the depth of tumor invasion (P<0.001), lymph node metastasis (P=0.024), stage (P<0.001) and CEA level (P= 0.005). No significant correlation between Ap53Ab expression and poor survival rate was observed. The positive rate of Ap53Ab was higher compared with that of CEA and CA19-9 in early-stage CRC. The combination of these markers improved the diagnostic yield of CRC up to ~60%. Furthermore, Ap53Ab expression was associated with lymph node metastasis, but not with shorter survival. These results indicated that the measurement of Ap53Ab may contribute to increased rate of detection of CRC, particularly in patients with early-stage disease, in clinical practice.

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Section: Ap53ab Expression N (%) -----------------------------------supporting

confidence: 81%

Clinical significance of serum anti-p53 antibody expression following curative surgery for colorectal cancer

Kumamoto

Ishida

Kuwabara

et al. 2017

Molecular and Clinical Oncology

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“…In the present study, we identified TRIM21 as a new SEREX antigen of esophageal SCC; s-TRIM21-Abs were present in 20% of patients with esophageal SCC. Although this rate was not higher than the positive rates of CYFRA 21-1, CEA or SCC-Ag (24-39%), (14) s-TRIM21-Abs were completely undetectable in all the healthy donors so far examined. Such specificity suggests that s-TRIM21-Abs might be useful in the detection of esophageal SCC.…”

Section: Discussionmentioning

confidence: 60%

“…(12) SEREX analysis has also led to the isolation of several antigens known to be associated with the malignant state, including a mutated version of p53 tumor suppressor protein in esophageal cancer. (13,14) Serum p53 antibodies have been associated with poor prognosis. (15) In the previous series of SEREX screening in esophageal SCC, we identified several new SEREX antigens including TROP2, SURF1 and HOOK2.…”

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confidence: 99%

Presence of serum tripartite motif‐containing 21 antibodies in patients with esophageal squamous cell carcinoma

et al. 2006

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“…However, since these methods are not suitable for daily analysis, a simpler method for p53 mutation detection is necessary. Recently, p53 protein overexpession was found to induce antibody production in patient serum and the detection of serum antibodies to p53 protein has been made easier by the enzyme-linked immunosorbent assay (ELISA) [2][3][4]. p53 protein has been shown to play an important role in the response to DNA damage induced by chemotherapeutic agents, such as cis-diammindichloroplatinum (CDDP) or 5-fluorouracil [5].…”

Section: Introductionmentioning

confidence: 99%

Clinical significance of serum p53 antibody detection on chemosensitivity assay in human colorectal cancer

et al. 1999

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Detection of serum p53 antibodies in patients with esophageal squamous cell carcinoma: correlation with clinicopathologic features and tumor markers.

Cited by 18 publications

References 0 publications

Clinical significance of serum anti-p53 antibody expression following curative surgery for colorectal cancer

Clinical significance of serum anti-p53 antibody expression following curative surgery for colorectal cancer

Presence of serum tripartite motif‐containing 21 antibodies in patients with esophageal squamous cell carcinoma

Clinical significance of serum p53 antibody detection on chemosensitivity assay in human colorectal cancer

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