Detection of selection signatures for agonistic behaviour in cattle

Abstract

The identification of genomic regions including signatures of selection produced by domestication and its subsequent artificial selection processes allows the understanding of the evolution of bovine breeds. Although several studies describe the genomic variability among meat or milk production cattle breeds, there are limited studies orientated towards bovine behavioural features. This study is focused on mapping genomic signatures of selection which may provide insights of differentiation between neutral and selected polymorphisms. Their effects are studied in the Lidia cattle traditionally selected for agonistic behaviour compared with Spanish breeds showing tamed behaviour. Two different approaches, BayeScan and SelEstim, were applied using genotypic 50K SNP BeadChip data. Both procedures detected two genomic regions bearing genes previously related to behavioural traits. The frequencies of the selected allele in these two regions in Lidia breed were opposite to those found in the tamed breeds. In these genomic regions, several putative genes associated with enriched metabolic pathways related to the behavioural development were identified, as neurochondrin gene (NCDN) or glutamate ionotropic receptor kainate type subunit 3 (GRIK3) both located at BTA3 or leucine-rich repeat and Ig domain containing 2 (LINGO2) and phospholipase A2-activating protein (PLAA) at BTA8.

Genome Wide Assessment of Genetic Variation and Population Distinctiveness of the Pig Family in South Africa

“…The number of mature individuals is estimated to be between 2000 and 5000 in the Kruger National Park (Ferreira et al, 2013). The geographical separation of the three national parks from which the warthogs were sampled, could have created small and fragmented subpopulations leading to escalated F IS values (Lamsyah et al, 2009) rs80854994 4 106,719,032 BCL2L15 Mastitis (Chen et al, 2015) Villages and DUR rs81282695 6 94,442,844 POU3F1 Neurobehavioral functioning (Eusebi et al, 2018) rs81282695 6 94442844 FHL3 Carcass traits (Zuo et al, 2004(Zuo et al, , 2007 Villages and KOL rs81430450 11 24,063,007 DNAJC15 Feeding efficiency (Reyer et al, 2017a) rs81430450 11 24,063,007 EPSTI1 Fertility traits (Gaddis et al, 2016), fat deposition (Zhang et al, 2018) SAL&LWT (Luo et al, 2012); carcass weight (Kang et al, 2013) Villages and WBO rs81244815 2 50,167,007 SWAP70 Disease resistance (Ma et al, 2011;Zhang et al, 2018) rs81244815 2 50,167,007 SBF2 Fertility (Zhang et al, 2014); immune function (Ibeagha-Awemu et al, 2016) rs81401075 8 73,841,435 FRAS1 Sow reproductive traits (Fischer et al, 2015), feed efficiency (Messad et al, 2019) rs81401075 8 73,841,435 NPY2R Obesity (Siddiq et al, 2007;Hunt et al, 2011) Villages (Smith et al, 2019); body width in gilts and sows (Rothschild, 2010), body weight traits (Borowska et al, 2017), altitude (Zhang et al, 2014) rs81478390 13 53,707,241 RYBP Body conformation traits -body weight, body length, body height, and chest circumference (Zhou et al, 2016) rs81330369 9 7,449,894 FCHSD2 Milk production traits (Kemper et al, 2015) rs80975991 7 33,481,446 ZFAND3 Growth and carcass quality traits (Li and Kim, 2015) rs80855522 4 11,0552,282 GNAI3 Heat tolerance (Berihulay et al, 2019) rs80988392 1 213,780,848 PTPRD Meat quality (Raschetti et al, 2013) due to Wahlund effect. As expected, we found that the village pig populations of South Africa had high inbreeding values compared with other popul...…”

Detection of selection signatures in Limousin cattle using whole‐genome resequencing

“…Interestingly, region 3.8 (ZHp = À3.00) contains GRIK3, a gene encoding glutamate ionotropic receptor kainate type subunit 3 and found in a selection scan performed in Lidia breed, a bovine breed known for its aggressive behaviour (Eusebi et al 2018). GRIK3 is highly expressed in the central nervous system and has been associated with personality traits in human (Minelli et al 2009).…”

Gene expression profiles underlying aggressive behavior in the prefrontal cortex of cattle

“…Lidia bovines belong to a primitive population, selected for centuries to develop agonistic-aggressive responses by means of a series of traits registered by the breeders on a categorical scale that classifies their aggression and fighting capacity, reporting moderate to high heritability estimates (0.20 -0.36) (Silva, Gonzalo & Cañón, 2006; Menéndez-Buxadera et al 2017). A recent study has identified significant genomic regions containing genes associated with aggressive behavior in the Lidia breed (Eusebi et al 2018), including a polymorphism in the promoter of the monoamine oxidase A (MAOA) gene, an important locus widely associated to pathological forms of aggression which, in humans, derives in a broad spectrum of psychiatric conditions, such as manic and bipolar disorders and schizophrenia, among others (Craig andHalton, 2009, Eusebi et al 2019).…”