Detection of SARS-CoV-2 in Nigeria: laboratory preparedness and report of index case

James, Ayorinde Babatunde; Salu, Olumuyiwa B.; Shaibu, Joseph Ojonugwa; Onwuamah, Chika; Mutiu, Bamidele; Amoo, Olufemi Samuel; Orenolu, Mercy Remilekun; Okwuraiwe, Azuka Patrick; Ndodo, Nnaemeka; Saka, Babatunde; Anyanwu, Roosevelt; Bankole, Munir Akinwale; Ige, Fehintola; Bankole, Mariam Abiodun; Abdus-Salam, Ismail; Abdus-Salam, Rosemary Ajuma; Osibogun, Akin; Abayomi, Akin; Ihekweazu, Chikwe; Salako, Babatunde Lawal; Omilabu, Sunday

doi:10.11604/pamj-oh.2021.5.9.27817

Cited by 2 publications

(2 citation statements)

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“…These cases were diagnosed using molecular-based methods. Several reasons have been suggested for the low prevalence of SARS CoV-2 infection in Africa, one of which is the low testing capacity due to the fragile health system and exiguous molecular laboratories [2][3][4][5]. Although studies have shown that over 80% of persons infected with the virus were asymptomatic [6][7][8][9][10], most of the tests conducted in African countries were among people with symptomatic infections [4,7,[11][12][13][14].…”

Section: Recruitment Of Participants Sample Collection and Processingmentioning

confidence: 99%

High Seroprevalence of SARS-COV-2 Antibody before Covid-19 Vaccination in Nigerian Communities

Do¹,

Aminu²,

Olusola³

et al. 2022

Int Arch Public Health Community Med

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Background: This community-based study was conducted to determine the proportion of individuals in the population that had been infected by the SARS-CoV-2 virus and developed antibodies before the second wave and introduction of COVID-19 vaccines in Nigeria. Methods:Between December 2020 and March 2021, 2,244 markets sellers and shoppers aged ≤ 70 years across six states [two northern (Kano and Kaduna), two eastern (Ebonyi and Imo), and two western (Oyo and Lagos)] regions were enrolled in the study. Demographic information was collected from the participants as well as whole blood which was separated into serum and tested for SARS-CoV-2 total antibodies with a validated ELISA kit (WANTAI SARS-CoV-2 Ab ELISA) approved by the U.S. Food and Drug Administration.Results: Overall, 1, 453 participants tested positive for the antibodies giving a seroprevalence of 66.8%. The antibodies were significantly (P = 0.0001) detected across the six states with the highest rate in Kano (83%) and the lowest rate in Lagos (39%). Participants who were ≤ 19 years and those between 60 and 69 years had the highest (68.42% (104/152) and lowest (56.20%: 68/121) seroprevalence rates respectively. In terms of religion, higher antibody levels were significantly (χ2 =17.4664, P = 0.0001) detected among Christians (75%: 576/766) compared to Muslims (65%: 395/609). There were no significant relationships between antibody positivity rates and gender, education, economic as well as marital status (p > 0.05). Conclusion:Six out of every ten participants in this study had antibodies against SARS-CoV-2 before the second wave and introduction of COVID-19 vaccines. Increased activities and mobility may be responsible for high levels of SARS-CoV-2 antibodies among young persons while differences in religious practices may account for the low prevalence of SARS-CoV-2 antibodies among Muslims compared to Christians.

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Section: Recruitment Of Participants Sample Collection and Processingmentioning

confidence: 99%

High Seroprevalence of SARS-COV-2 Antibody before Covid-19 Vaccination in Nigerian Communities

Do¹,

Aminu²,

Olusola³

et al. 2022

Int Arch Public Health Community Med

View full text Add to dashboard Cite

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“…COVID-19 was declared a pandemic on 11 March 2020 by the WHO.Nigeria had its index case on the27th February 2020 at the Infectious Disease Hospital, Yaba, Lagos. The index case was a 44-yearoldItalian male expatriate who returned from a family visit in Italy (Ayorinde et al, 2021). It has been reported that healthcare workers (HCWs) are exceptionally at risk of the pandemic since they are in the frontline and therefore at high exposure rate to the virus (El-Sokkary et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Sero-Detection of Sars-Cov-2 Antibodies and some Associated Risk Factors among Staff of Federal University Gusau, Zamfara State, Nigeria

Mohammed¹

2023

AJBAR

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This study was aimed at detecting the level of SARS-CoV-2 antibody response among the staff of Federal University Gusau, Zamfara State. A cross-sectional study design and clusteredstratified-random sampling strategy were used to sample staff of the University comprising academic, technical and non-academic staff. SARS CoV-2 antigen Rapid Tests were carried out using on the spot analysis of nasopharyngeal and blood samples of the participants using SARS-CoV-2 antigen RDT kits and total antibody ELISA kit. None of the samples collected was positive to the antigen RDT kit, however further confirmation with ELISA kit revealed a prevalence of 32.8%. This study showed that academic staffs are more exposed to SARS-CoV-2 viruses due to high incidence of antibodies detected among the academics; however, the difference in the prevalence between academic and non-academic staff was not statistically significant. Knowledge of SARS-CoV-2, belief, behaviour towards COVID19 protocols, contact history and flu-like symptoms were risk factors that predispose one to SARS-CoV-2 viruses.

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Detection of SARS-CoV-2 in Nigeria: laboratory preparedness and report of index case

Cited by 2 publications

References 0 publications

High Seroprevalence of SARS-COV-2 Antibody before Covid-19 Vaccination in Nigerian Communities

High Seroprevalence of SARS-COV-2 Antibody before Covid-19 Vaccination in Nigerian Communities

Sero-Detection of Sars-Cov-2 Antibodies and some Associated Risk Factors among Staff of Federal University Gusau, Zamfara State, Nigeria

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