Detection of SARS-CoV-2 Among Residents and Staff Members of an Independent and Assisted Living Community for Older Adults — Seattle, Washington, 2020

Roxby, Alison C.; Greninger, Alexander L.; Hatfield, Kelly M; Lynch, John B.; Dellit, Timothy H.; James, Allison; Taylor, Joanne; Page, Libby C.; Kimball, Anne; Arons, Melissa; Schieve, Laura A.; Munanga, Albert; Stone, Nimalie D.; Jernigan, John A.; Reddy, Sujan; Lewis, James; Cohen, Seth A.; Jerome, Keith R.; Duchin, Jeffrey S.; Neme, Santiago

doi:10.15585/mmwr.mm6914e2

Cited by 121 publications

(115 citation statements)

References 3 publications

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“…Several studies have highlighted a proportion of individuals testing positive for SARS-CoV-2 are asymptomatic. [1][2][3][4][5][6]8,9 However, the prevalence of asymptomatic cases varies substantially, possibly due to the sampling and the settings of the study. 8 The findings from our analyses suggest that asymptomatic cases of COVID-19 were widespread in the UK in Spring 2020.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

<p>Three Quarters of People with SARS-CoV-2 Infection are Asymptomatic: Analysis of English Household Survey Data</p>

Petersen¹,

Phillips²

2020

CLEP

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Background: To reduce transmission of SARS-CoV-2, it is important to identify those who are infectious. However, little is known about what proportion of infectious people are asymptomatic and potential "silent" transmitters. We evaluated the value of COVID-19 symptoms as a marker for SARS-CoV-2 infection from a representative English survey. Methods: We used data from the Office for National Statistics Coronavirus (COVID-19) Infection Survey pilot study. We estimated sensitivity, specificity, the proportion of asymptomatic cases (1sensitivity), positive predictive value (PPV) and negative predictive value (NPV) of COVID-19 symptoms as a marker of infection using results of the SARS-CoV-2 test as the "gold standard". Results: In total, there were 36,061 individuals with a SARS-CoV-2 test between 26 April and 27 June 2020. Of these, 625 (1.7%) reported symptoms on the day of the test. There were 115 (0.32%) with a positive SARS-CoV-2 test result. Of the 115, there were 27 (23.5%) who were symptomatic and 88 (76.5%) who were asymptomatic on the day of the test. Focusing on those with specific symptoms (cough, and/or fever, and/or loss of taste/smell), there were 158 (0.43%) with such symptoms on the day of the test. Of the 115 with a positive SARS-CoV-2, there were 16 (13.9%) reporting symptoms. In contrast, 99 (86.1%) did not report specific symptoms on the day of the test. The PPV for all symptoms was 4.3% and for the specific symptoms 10.1%. The specificity and NPV of symptoms were above 98%. Conclusion: COVID-19 symptoms are poor markers of SARS-CoV-2. Thus, 76.5% of this random sample who tested positive reported no symptoms, and 86.1% reported none of those specific to COVID-19. A more widespread testing programme is necessary to capture "silent" transmission and potentially prevent and reduce future outbreaks.

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Section: Discussionmentioning

confidence: 99%

“…However, there are several reports suggesting that not all individuals with a positive SARS-CoV-2 RNA test result have symptoms. [1][2][3][4][5][6][7] The proportion of asymptomatic cases varies substantially between studies and settings. 8 For example, among 262 confirmed cases admitted to hospitals in Beijing 13 (5%) were asymptomatic.…”

Section: Introductionmentioning

confidence: 99%

<p>Three Quarters of People with SARS-CoV-2 Infection are Asymptomatic: Analysis of English Household Survey Data</p>

Petersen¹,

Phillips²

2020

CLEP

View full text Add to dashboard Cite

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“…8 There is already evidence that screening based on typical symptoms alone, which failed in this case, is insufficient to identify COVID-19 in older adults. 9,10 This has significant implications for both clinical care and infection prevention and control, particularly in congregate living settings such as nursing homes, where frail older adults have experienced disproportionately high COVID-19-related morbidity and mortality. Given this, emerging recommendations are increasingly emphasizing the consideration of COVID-19 in older adults with any significant change from baseline.…”

Section: Discussionmentioning

confidence: 99%

Typically Atypical: COVID‐19 Presenting as a Fall in an Older Adult

Norman

Stall

Sinha

2020

J American Geriatrics Society

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“…48,49 The problem involves the residents, their family members and medical, nurse personnel if protection protocols are poorly implemented. 50 The Italian National Health System was established with the Law N. 833, on 23 December 1978. This law was based on the equity of care and underlined the precious role of primary prevention, parallel to adequate health assistance and rehabilitation.…”

Section: Discussionmentioning

confidence: 99%