Detection of Saint Louis encephalitis virus in two Brazilian states

Moraes, Marília Mazzi; Kubiszeski, Janaína Rigotti; Vieira, Carla Júlia da Silva Pessoa; Gusmão, Arianne Fagotti; Pratis, Taina Silva; Colombo, Tatiana Elias; Thies, Sirlei Franck; Araujo, Fabiana do Carmo; Zanelli, Cleslei Fernando; Milhim, Bruno Henrique Gonçalves de Aguiar; Silva, Gislaine Celestino Dutra da; Nogueira, Maurício Lacerda; Pacca, Carolina Colombelli; Bronzoni, Roberta Vieira de Morais

doi:10.1002/jmv.27402

Cited by 7 publications

(4 citation statements)

References 17 publications

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“…In this study, using portable nanopore sequencing, we generated three new WNV-1a genomes collected between 2017 and 2019 from the northeastern region of Brazil. Among the zoonotic arboviruses detected in Brazil [ 14 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ], since 2004, several studies have provided serological evidence regarding the circulation of West Nile virus (WNV) in mammal and bird reservoirs [ 10 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 40 , 41 , 42 ]. Even though the circulation of WNV has been documented since 2004, the short period of infection, followed by a low viremia and the difficulty of accessing the possible infected animals reduced the possibility of molecular confirmation and sequencing [ 9 , 10 , 14 , 15 , 16 , 17 , 18 , 20 , 40 , 41 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

Retrospective Investigation in Horses with Encephalitis Reveals Unnoticed Circulation of West Nile Virus in Brazil

Fritsch

Pereira²,

Costa

et al. 2022

Viruses

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During these past years, several studies have provided serological evidence regarding the circulation of West Nile virus (WNV) in Brazil. Despite some reports, much is still unknown regarding the genomic diversity and transmission dynamics of this virus in the country. Recently, genomic monitoring activities in horses revealed the circulation of WNV in several Brazilian regions. These findings on the paucity of genomic data reinforce the need for prompt investigation of WNV infection in horses, which may precede human cases of encephalitis in Brazil. Thus, in this study, we retrospectively screened 54 suspicious WNV samples collected between 2017 and 2020 from the spinal cord and brain of horses with encephalitis and generated three new WNV genomes from the Ceará and Bahia states, located in the northeastern region of Brazil. The Bayesian reconstruction revealed that at least two independent introduction events occurred in Brazil. The first introduction event appears to be likely related to the North American outbreak, and was estimated to have occurred in March 2013.The second introduction event appears to have occurred in September 2017 and appears to be likely related to the South American outbreak. Together, our results reinforce the importance of increasing the priority of WNV genomic monitoring in equines with encephalitis in order to track the dispersion of this emerging pathogen through the country.

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Section: Discussionmentioning

confidence: 99%

Retrospective Investigation in Horses with Encephalitis Reveals Unnoticed Circulation of West Nile Virus in Brazil

Fritsch

Pereira²,

Costa

et al. 2022

Viruses

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“…In Brazil, only three cases of SLEV in humans were reported in the 1970s, two in the northern region and a third identified in the municipality of São Pedro/SP in 2004 [65]. More recently, the detection of SLEV was described in humans in the states of São Paulo and Mato Grosso during outbreaks of DENV and ZIKV [66].…”

Section: Saint Louis Encephalitis Virus (Slev)mentioning

confidence: 99%

Isolation of Flaviviruses and Alphaviruses with Encephalitogenic Potential Diagnosed by Evandro Chagas Institute in the Period of 1954–2022: Six Decades of Discoveries

Wanzeller¹,

Barros²,

Freitas³

et al. 2023

Preprint

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Viruses with encephalitogenic potential can cause neurological conditions of clinical and epidemiological importance, such as Saint Louis encephalitis virus, Venezuelan equine encephalitis virus, Eastern equine encephalitis virus, Western equine encephalitis virus, dengue virus, Zika virus, Chikungunya virus, Mayaro virus and West Nile virus. The objective of the present study was to determine the number of arboviruses with neuroinvasive potential isolated in Brazil that corresponds to the collection of viral samples belonging to the Section of Arbovirology and Hemorrhagic Fevers (SAARB/IEC) of the Laboratory Network of National Reference for Arbovirus Diagnosis from 1954 to 2022. A total of 1,090 arbovirus samples with encephalitogenic potential were isolated from mice. From a total of 7,054 samples intended for cell culture. The isolates from mosquitoes totaled 659 viruses. The emergence of new arboviruses may be responsible for diseases still unknown to humans, making the Amazon region a hotspot for infectious diseases due to its fauna and flora species characteristics. The detection of circulating arboviruses with the potential to cause neuroinvasive diseases is constant, which justifies the continuation of active epidemiological surveillance work that offers adequate support to the public health system regarding the virological diagnosis of circulating arboviruses in Brazil.

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“…The municipality of Sinop, MT, is located in the Arc of Deforestation and has heterogeneous habitats characterized by an urban–forest–rural landscape, which could be favourable for arboviruses emergence. In fact, Sinop has reported the co‐circulation of different arboviruses, including the emergence of MAYV (Vieira et al., 2015) and SLEV (Moraes et al, 2019), which have been silently circulating during dengue outbreaks. Determining the basic ecology of mosquito communities is crucial for understanding how deforestation and forest fragmentation influence the vector community and provides insights into where disease risk will increase (Steiger et al., 2012).…”

Section: Introductionmentioning

confidence: 99%

Land‐use effects on mosquito biodiversity and potential arbovirus emergence in the Southern Amazon, Brazil

Vieira

Bernardo

Silva

et al. 2021

Transbounding Emerging Dis

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The Amazon rainforest is considered the largest reservoir of culicids and arboviruses in the world. It has been under intense human‐driven alteration, especially in the so‐called ‘Arc of Deforestation’, located in the eastern and southern regions. The emergence and transmission of infectious diseases are increasing, potentially due to land‐use change. We used landscape‐scale mosquito surveillance across a forest fragmentation gradient in the southern Amazon to evaluate the relationship between forest disturbance and the composition and structure of mosquito communities with a particular focus on the potential for arbovirus emergence in the region. Generalized linear models and logistic regression were used to associate the degree of landscape disturbance with arbovirus vectors’ richness and abundance. A total of 1,960 culicids, belonging to 50 species, were collected from 2015 to 2016. Among these species, 20 have been associated with the transmission of arboviruses. Our results show an association of land use, more specifically small size of forest remnants with more irregular shape and higher edge density, with the increase of arbovirus vectors’ richness and abundance. Six species of mosquito vectors exhibited a higher probability of occurrence in landscapes with medium or high degrees of disturbance. Our results indicate that land‐use change influences mosquito communities with potential implications for the emergence of arboviruses.

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Detection of Saint Louis encephalitis virus in two Brazilian states

Cited by 7 publications

References 17 publications

Retrospective Investigation in Horses with Encephalitis Reveals Unnoticed Circulation of West Nile Virus in Brazil

Retrospective Investigation in Horses with Encephalitis Reveals Unnoticed Circulation of West Nile Virus in Brazil

Isolation of Flaviviruses and Alphaviruses with Encephalitogenic Potential Diagnosed by Evandro Chagas Institute in the Period of 1954–2022: Six Decades of Discoveries

Land‐use effects on mosquito biodiversity and potential arbovirus emergence in the Southern Amazon, Brazil

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