Detection of Rhabdomyolysis in Patients Admitted to Emergency Department due to Drug Overdose as a Suicide Attempt: A Propective Original Clinical Study

Quantitative Structure–Activity Relationship (QSAR) Model for the Severity Prediction of Drug-Induced Rhabdomyolysis by Using Random Forest

“…Drug-induced rhabdomyolysis (DIR) is a potentially life-threatening muscle injury that will lead to the damage of skeletal muscle, resulting in the release of cellular contents into the blood and a variety of clinical symptoms ranging from nonspecific fatigue and muscle pain to acute kidney failure. − The specific pathogenesis of rhabdomyolysis is still unknown due to the many interfering factors leading to rhabdomyolysis. ,, The timely identification and early intervention of rhabdomyolysis are critical, considering the fact that it will cause approximately 10%∼ 25% cases of acute renal failure. − A full recovery can be expected through early diagnosis and the treatment of the complications that may arise. , At present, the main diagnostic method in clinics is to monitor the levels of serum and urine myoglobin as well as the level of serum creatine kinase (CK), which will be 5–10 times higher than the normal serum levels in patients. , In fact, it limits the diagnostic performance that the detected CK values are usually inconsistent . It is still an arduous task in clinical practice to carry out the early detection and intervention of DIR.…”