Detection of retinal nerve fiber layer degeneration in patients with Alzheimer's disease using optical coherence tomography: searching new biomarkers

Visual function and retinal nerve fibre layer degeneration in patients with Alzheimer disease: correlations with severity of dementia

“…In a previous article (Bambo et al 2014), we described retinal nerve fibre layer (RNFL) thickness differences between 57 patients with mild-moderate AD and 57 healthy controls based on the two most commonly available spectraldomain optical coherence tomography (SD-OCT) devices. Significant thinning of the superior and inferior RNFL in the Cirrus OCT (Carl Zeiss, Meditec, Inc., Dublin, Ireland) and significant thinning of the inferior and inferotemporal RNFL in the Spectralis OCT (Heidelberg Engineering, Inc., Carlsbad, CA, USA) were observed.…”

“…W e congratulate Bambo et al (Bambo et al 2014) for their study entitled 'Detection of retinal nerve fibre layer degeneration in patients with Alzheimer's disease using optical coherence tomography: searching new biomarkers'. The authors compared retinal nerve fibre layer (RNFL) thickness differences between patients with Alzheimer's disease and healthy controls using the two most commonly available spectral-domain optical coherence tomography (SD-OCT) machines.…”

Retinal oximetry is affected in multiple sclerosis

“…Optical coherence tomography (OCT) of the retina has demonstrated thinning of the retinal nerve fibre layer (RNFL) in central nervous system diseases, such as multiple sclerosis (MS) (Garcia-Martin et al 2013;Park et al 2014), Parkinsońs disease (Lee et al 2014) and Alzheimer's disease (Marziani et al 2013;Bambo et al 2014). Optical coherence tomography (OCT) of the retina has demonstrated thinning of the retinal nerve fibre layer (RNFL) in central nervous system diseases, such as multiple sclerosis (MS) (Garcia-Martin et al 2013;Park et al 2014), Parkinsońs disease (Lee et al 2014) and Alzheimer's disease (Marziani et al 2013;Bambo et al 2014).…”

Glia-Mediated Retinal Neuroinflammation as a Biomarker in Alzheimer's Disease

“…There were reports demonstrating a decrease in the thickness of RNFL in AD patients [5,70,71,72,73,74,75,76], while other studies found no differences in the RNFL thickness of AD patients [77,78]. These inconsistent results might be due to the distinct evaluation techniques, as well as the evaluation criteria, such as the retinal region [73].…”

“…A recent study showed that changes in RNFL might be dependent on the progression of the pathology [79]. With the evaluation of RNFL being performed with spectral OCT, a noninvasive and cost-effective technique that allows the quantification of retinal layer thickness, it is reasonable to hypothesize that a reduction in RNFL thickness may be used as an early biomarker for AD [65,74,75]. …”