Detection of respiratory coinfections in pediatric patients using a small volume polymerase chain reaction array respiratory panel: More evidence for combined droplet and contact isolation

Abstract

SVPCR array RP testing detected respiratory pathogens in pediatric patients with URI at rates higher than that of RAT and viral culture. Because of the pathogens and pathogen combinations detected, the study findings suggest that combined contact and droplet isolation precautions may be warranted to prevent health care-associated infection in pediatric inpatients with URI. Further studies will be needed to confirm these results.

Association of Respiratory Picornaviruses With High Acuity and Severe Illness in a Pediatric Health Care System

“…10,11,15,26 RSV was the most common coinfection. However, even when visits of patients with multiple viral infections were excluded from our logistic regression model, picornavirus detection was independently associated with ICU admission.…”

Diagnostic Molecular Microbiology

“…Furthermore, mixed infections are more common than many had imagined. 35,36 Some virus infections are treatable, and others have different isolation requirements if the patient is hospitalized. 36 Thus, molecular panels that could detect multiple etiologic agents of diseases clearly are desirable.…”

“…35,36 Some virus infections are treatable, and others have different isolation requirements if the patient is hospitalized. 36 Thus, molecular panels that could detect multiple etiologic agents of diseases clearly are desirable. As of December 2017, 6 multiplex respiratory panels are FDA approved: Luminex xTAG RVP (xRVP) and RVP Fast (xRVPF) and Verigene respiratory pathogen flex (LUMINEX corporation); Film Array Respiratory Panel (FARP; BioFire Diagnostics [Now bioMerieux], Salt Lake City, UT), and the eSensor respiratory viral panel, ePlex Respiratory Pathogen Panel (GenMark Diagnostics, Carlsbad, CA).…”

Diagnostic Molecular Microbiology

“…Furthermore, mixed infections are more common than many had imagined. 41,42 Some virus infections are treatable, and others have different isolation requirements if the patient is hospitalized. 42 Thus, molecular panels that could detect multiple etiologic agents of diseases clearly are desirable.…”

“…41,42 Some virus infections are treatable, and others have different isolation requirements if the patient is hospitalized. 42 Thus, molecular panels that could detect multiple etiologic agents of diseases clearly are desirable. Four multiplex respiratory panels are FDA approved at this writing: Luminex xTAG RVP (xRVP) and RVP Fast (xRVPF) (Luminex Diagnostics, Toronto, Canada); Film Array Respiratory Panel (FARP; BioFire Diagnostics [formerly Idaho Technologies], Salt Lake City, UT), and eSensor Respiratory Panel (eSRP) (GenMark Diagnostics, Carlsbad, CA).…”