Detection of renal diseases in humans: developing markers and methods

Mutti, Antonio

doi:10.1016/0378-4274(89)90126-4

Cited by 36 publications

(7 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Brush-border, liposomal, and cytosolic enzymes are excreted in the urine of healthy subjects and enzymuria is expected to rise as a consequence of cell breakdown, necrosis and increased cellular turnover [47]. Therefore, the type of enzymuria reflects the site of damage to proximal tubules.…”

Section: Biological Characteristics Of Neonatesmentioning

confidence: 99%

Clinical Pharmacology of Furosemide in Neonates: A Review

Pacifici

2013

Pharmaceuticals

View full text Add to dashboard Cite

Furosemide is the diuretic most used in newborn infants. It blocks the Na+-K+-2Cl− symporter in the thick ascending limb of the loop of Henle increasing urinary excretion of Na+ and Cl−. This article aimed to review the published data on the clinical pharmacology of furosemide in neonates to provide a critical, comprehensive, authoritative and, updated survey on the metabolism, pharmacokinetics, pharmacodynamics and side-effects of furosemide in neonates. The bibliographic search was performed using PubMed and EMBASE databases as search engines; January 2013 was the cutoff point. Furosemide half-life (t1/2) is 6 to 20-fold longer, clearance (Cl) is 1.2 to 14-fold smaller and volume of distribution (Vd) is 1.3 to 6-fold larger than the adult values. t1/2 shortens and Cl increases as the neonatal maturation proceeds. Continuous intravenous infusion of furosemide yields more controlled diuresis than the intermittent intravenous infusion. Furosemide may be administered by inhalation to infants with chronic lung disease to improve pulmonary mechanics. Furosemide stimulates prostaglandin E2 synthesis, a potent dilator of the patent ductus arteriosus, and the administration of furosemide to any preterm infants should be carefully weighed against the risk of precipitation of a symptomatic patent ductus arteriosus. Infants with low birthweight treated with chronic furosemide are at risk for the development of intra-renal calcifications.

show abstract

Section: Biological Characteristics Of Neonatesmentioning

confidence: 99%

Clinical Pharmacology of Furosemide in Neonates: A Review

Pacifici

2013

Pharmaceuticals

View full text Add to dashboard Cite

show abstract

“…An increase in urinary NAG levels is considered an indicator of nonspeci®c microdamage to proximal tubule cells, that is, cell breakdown, necrosis, or increased cellular turnover [18,24]. In fact, urinary NAG excretion is clinically used as a biological marker of disease-related renal damage in cases of diabetes mellitus, hypertension, and rheumatoid arthritis [29,30].…”

Section: Introductionmentioning

confidence: 99%

Occupational exposure to airborne mercury during gold mining operations near El Callao, Venezuela

Drake

Rojas

Reh

et al. 2001

International Archives of Occupational and Environmental Health

View full text Add to dashboard Cite

show abstract

“…Some evidence suggests that Hg elimination via urine occurs in two exponential phases. (28)(29)(30)(31)(32)(33) These manifestations can diminish the ability of proximal tubular segments to reabsorb water, proteins, and other glomerular ltrates, thus affecting the kidneys' ability to maintain volume and composition of bodily uids within normal limits. The majority of the Hg body burden is eliminated through a slow phase with a half-life of 40 to 60 days.…”

Section: Mercury-exposure-related Health Effects and Exposure Criteriamentioning

confidence: 99%