Detection of recurrent or persistent nasopharyngeal carcinomas after radiotherapy with technetium‐99m methoxyisobutylisonitrile single photon emission computed tomography and computed tomography

Kao, Chia‐Hung; Shiau, Yu‐Chien; Shen, Yeh-You; Yen, Ruoh‐Fang

doi:10.1002/cncr.10400

Cited by 51 publications

(43 citation statements)

References 30 publications

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“…The sensitivities in these articles cited ranging from 67% to 100% and specificities ranging from 77% to 100%. [18][19][20][21][22] Our results are comparable with these findings (sensitivity 100% and specificity 83%) supporting the assertion that 18F-FDG PET should be a sensitive tool in detecting residual or recurrent nodes in NPC. In fact, by incorporating CT into functional PET imaging, the percentage is expected to be higher as compared to PET imaging alone.…”

Section: Comparing Results Between Imaging Modalities For the Assessmsupporting

confidence: 86%

Imaging in nasopharyngeal carcinoma: the value of 18-Florine Fluorodeoxyglucose PET/CT in comparison to conventional imaging modalities CT and MRI

Nordin

Secondino

Rahim

et al. 2009

Radiology and Oncology

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Section: Comparing Results Between Imaging Modalities For the Assessmsupporting

confidence: 86%

Imaging in nasopharyngeal carcinoma: the value of 18-Florine Fluorodeoxyglucose PET/CT in comparison to conventional imaging modalities CT and MRI

Nordin

Secondino

Rahim

et al. 2009

Radiology and Oncology

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“…Moreover, locoregional recurrences, after combined therapeutic modalities including conservative surgery, usually occur later. 18 F-FDG PET performed as a sequential investigation 4 mo after treatment, independent of whether recurrence is suggested, showed high accuracy (12,14,21,22). However, recurrences could also be apparent clinically or radiographically at the time of PET.…”

Section: Discussionmentioning

confidence: 96%

“…18 F-FDG PET offers a tool that enables the early detection of HNSCC recurrences. 18 F-FDG PET can distinguish recurrent HNSCC from posttreatment changes and is more effective in detecting recurrent tumors than physical examination, CT, or MRI (8)(9)(10)(11)(12)(13). However, in most of these studies, the objective was to assess the ability of 18 F-FDG PET to visualize a recurrence that was clinically already highly suspected.…”

mentioning

confidence: 99%

¹⁸F-FDG PET as a Routine Posttreatment Surveillance Tool in Oral and Oropharyngeal Squamous Cell Carcinoma: A ProspectiveStudy

Krabbe¹,

Pruim²,

Dijkstra³

et al. 2009

J Nucl Med

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The purpose of this study was to evaluate the role and timing of serial 18 F-FDG PET scans as routine surveillance for detecting early locoregional recurrence, distant metastases, and second primary tumors in patients treated for advanced squamous cell carcinoma (SCC) in the oral cavity or oropharynx during the first year after completion of their curative treatment. Methods: Forty-eight consecutive patients with SCC in the oral cavity or oropharynx were included after completing their initial therapy with curative intent. Prospective follow-up of the participants was 2-fold: regular follow-up (history and physical examination) and serial 18 F-FDG PET scans. Patients underwent standard follow-up and 18 F-FDG PET at 3, 6, 9, and 12 mo after initial treatment. Findings were validated by histopathology or 18 mo of clinical follow-up and imaging after initial treatment. Results: Incidence of recurrences and second primary tumors was 27% and 10%, respectively. 18 F-FDG PET was significantly (P 5 0.035) more often in agreement with the gold standard than was regular follow-up. 18 F-FDG PET showed a sensitivity, specificity, positive predictive value, and negative predictive value of 100%, 43%, 51%, and 100%, respectively. For regular followup, these values were 0%, 60%, 0%, and 50%, respectively. 18 F-FDG PET accounted for a change in diagnostics or treatment in 63% of the patients and regular follow-up in 25% of the patients. Sensitivity and specificity of 18 F-FDG PET were both irrespective of timing of 18 F-FDG PET. For the 3-and 6-mo posttherapy results combined, 18 F-FDG PET detected malignancy in 16 of the 18 patients. Conclusion: 18 F-FDG PET is a suitable routine posttreatment surveillance tool in oral and oropharyngeal SCC patients and detects malignancy before clinical suggestion by the regular follow-up arises. The best timing of a systematic 18 F-FDG PET scan is between 3 and 6 mo after treatment.

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“…[20] Another study found a higher percentages for sensitivity (88%) and specificity (94%). [21] Shiau et al [22] reported a 64% sensitivity for 99m Tc-MIBI in primary tumor detection and 73% [23] for tumor recurrence. Shen et al [15] reported higher specificity, but lower sensitivity for 99m Tc-TF, as compared to CT.…”

Section: Discussionmentioning

confidence: 99%

The role of technetium Tc99m-tetrofosmin as head and neck tumor-seeking agent: a preliminary report

Sioka¹,

Exarchopoulos²,

Skloupiotis³

et al. 2016

JCMT

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Aim:To evaluate the diagnostic value of technetium Tc99m-tetrofosmin ( 99m Tc-TF) in primary cancers of the head and neck. Methods: Single photon emission computer tomography with planar imaging of the neck for primary site evaluation and whole body scanning for assessment of metastases in 12 patients with newly diagnosed head and neck cancer. Tumor-to-background index (T/Bg) was derived in patients with positive findings (tumor or lymph nodes). Results: The tomographic images showed increased tracer uptake in pathological sites (primary tumor or lymph node) in 9 patients (overall sensitivity 75%). Primary tumor was visualised in 7 patients (sensitivity 58%) and infiltrated lymph nodes in 4 out 7 patients (sensitivity 57%). Mean values for T/Bg index were 5.44 ± 1.28 for primary tumor and 4.25 ± 1.67 for lymph nodes. Mean values for T/Bg index were 4.5 ± 0.71 for patients with in situ and grade I carcinoma and 6.68 ± 0.36 for patients with tumor grade II and III (P = 0.034, Mann-Whitney U test). Conclusion: The present study demonstrates that 99m Tc-TF is a valuable radiotracer for head and neck cancer imaging. To determine the potential role of this imaging protocol in clinical practice will require a larger sample size.

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Detection of recurrent or persistent nasopharyngeal carcinomas after radiotherapy with technetium‐99m methoxyisobutylisonitrile single photon emission computed tomography and computed tomography

Cited by 51 publications

References 30 publications

Imaging in nasopharyngeal carcinoma: the value of 18-Florine Fluorodeoxyglucose PET/CT in comparison to conventional imaging modalities CT and MRI

Imaging in nasopharyngeal carcinoma: the value of 18-Florine Fluorodeoxyglucose PET/CT in comparison to conventional imaging modalities CT and MRI

¹⁸F-FDG PET as a Routine Posttreatment Surveillance Tool in Oral and Oropharyngeal Squamous Cell Carcinoma: A ProspectiveStudy

The role of technetium Tc99m-tetrofosmin as head and neck tumor-seeking agent: a preliminary report

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Detection of recurrent or persistent nasopharyngeal carcinomas after radiotherapy with technetium‐99m methoxyisobutylisonitrile single photon emission computed tomography and computed tomography

Cited by 51 publications

References 30 publications

Imaging in nasopharyngeal carcinoma: the value of 18-Florine Fluorodeoxyglucose PET/CT in comparison to conventional imaging modalities CT and MRI

Imaging in nasopharyngeal carcinoma: the value of 18-Florine Fluorodeoxyglucose PET/CT in comparison to conventional imaging modalities CT and MRI

18F-FDG PET as a Routine Posttreatment Surveillance Tool in Oral and Oropharyngeal Squamous Cell Carcinoma: A ProspectiveStudy

The role of technetium Tc99m-tetrofosmin as head and neck tumor-seeking agent: a preliminary report

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¹⁸F-FDG PET as a Routine Posttreatment Surveillance Tool in Oral and Oropharyngeal Squamous Cell Carcinoma: A ProspectiveStudy