DETECTION OF RDRIOSTRAIN OFMYCOBACTERIUM TUBERCULOSISIN TAPIRS (TAPIRUS TERRESTRIS) FROM A ZOO IN BRAZIL

Murakami, P. S.; Monego, Fernanda; Ho, John L.; Gibson, Andrea L.; Javorouski, Manoel Lucas; Bonat, Marcelo; Lacerda, Oneida; Brockelt, Sonia Regina; Biesdorf, Sonia Maria; Nakatani, Sueli M.; Riediger, Irina Nastassja; Fuverki, Renata Benício Neves; Biava, Janaína Socolovski; Vieira, Rafael Felipe da Costa; Santos, Andrea Pires do; Filho, Ivan Roque de Barros; Biondo, Alexander Welker

doi:10.1638/2010-0108r.1

Cited by 22 publications

(16 citation statements)

References 10 publications

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“…http://seer.ufrgs.br/ActaScientiaeVeterinariae clinical and anatomopathological similarities with the infections of a tapir and coati at the zoo of Curitiba, Paraná state [8], and non-human primates in bioteries in Belém, Pará state [4]. In the present case, as in the others previously reported, Mycobacterium tuberculosis complex was detected identified.…”

Section: Cr321supporting

confidence: 79%

“…Tuberculosis in a Malayan tapir showed multiple white, caseous nodules measuring from 1 to 5 mm in diameter spread throughout the lungs [2]. The authors did not mention the manifestation of acinar processes; however, the lesions can be generalized and present in the mediastinal lymph nodes and in the liver, spleen, kidneys, ovaries, areas of the serosa, diaphragm, mesenteric lymph nodes, intestines and uterus [8].…”

Section: Cr321mentioning

confidence: 99%

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Tuberculosis Caused by Mycobacterium tuberculosis Complex in a Captive Tapir (Tapirus terrestris)

Pereira

Filho

Campos³

et al. 2018

Acta Scientiae. Vet.

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Background:Tuberculosis is an infectious disease caused by the Mycobacterium tuberculosis complex has already been identified in a great number of wild species. Captive animals may have a potential source for zoonoses, because is related to factors such as cohabitation, direct contact with the public, presence of biological vectors, nutritional deficiencies, absence of sanitary barriers, precautionary hygienic measures and sanitary vigilance. In Brazil, there is little information on tuberculosis in captivity animals, and little attention is given to the risks of disease transmission from humans. The aim of this study was to report the first diagnosed case of tuberculosis Tapirus terrestris in Brazilian Amazon region. Case: One Tapirus terrestris was kept by local zoobotanic foundation in city of Marabá, Southeast of Pará state, Brazilian Amazon, and became ill. Physical examination revealed cough, sneezing, nasal outflow, dyspnea, hyperthermia and lethargy, leading to death. Necropsy demonstrated severe pulmonary alterations: thickening of the inter-alveolar septa, alveolar emphysema, and miliary nodules with dimensions up to 5 mm, which were yellowish-white, caseous, and sometimes calcified. Additionally, large areas of caseous compaction of the parenchyma, characteristic of caseous tuberculosis. Histopathological analysis revealed a process characteristic of mycobacterial infection, with alveoli filled with caseous exudate and thickened septa and fibrocytes, in addition to recently formed tubercles, some with caseous necrosis, calcifications and Langhans cells. In the Ziehl-Neelsen staining, alcohol-acid resistant bacilli were observed in the mesenteric lymph nodes. No mycobacterial growth was observed in Lowenstein-Jensen culture medium. A nested PCR followed by a sequencing assay targeting the hsp65 gene and M. tuberculosis complex member was detected. Water and M. tuberculosis H37Rv were used as negative and positive controls, respectively. Discussion: This article reports the first case of tuberculosis in T. terrestris in Amazonia. The case of infection was caused by a complex of Mycobacterium tuberculosis, as well as reports of other studies described in wild animals. This record presented clinical and pathological similarity with the cases of a tapir and coati at the zoo of Curitiba, and non-human primates in bioteries in Belém. The disease was reported, also, in a T. indicus female in Bangkok, Thailand. In another study with two tapirs there was positivity of tuberculin test result in a Swedish zoo. In necropsy findings of tuberculosis in a Malayan tapir showed multiple white, caseous nodules spread throughout the lungs. Studies have shown that lesions can be in various organs, among them the mediastinal and mesenteric lymph nodes, liver, spleen, kidneys, ovaries, serosa, diaphragm, intestines and uterus. For exemple in a case of disseminated tuberculosis caused by M. tuberculosis in a Malayan tapir were described multiple granulomes, some coalescent, characterized by necrotic caseous centers, with some...

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Section: Cr321supporting

confidence: 79%

Section: Cr321mentioning

confidence: 99%

Tuberculosis Caused by Mycobacterium tuberculosis Complex in a Captive Tapir (Tapirus terrestris)

Pereira

Filho

Campos³

et al. 2018

Acta Scientiae. Vet.

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“…Furthermore, there is some reluctance to publicize findings due to public relations impact and loss of revenue (KANEENE et al, 2010). The present study revealed the occurrence of M. tuberculosis complex in Barbary sheep, an exotic species; however, the same Brazilian zoo described in 2006 the first report of RD Rio M. tuberculosis infection in tapirs (MURAKAMI et al, 2012). Not surprisingly, wild animal species are thought to be reservoirs for more than 70% of all emerging infections (KUIKEN et al, 2005;CHOMEL et al, 2007) (MICHEL et al, 2003), antelopes, capuchin and vervet monkeys (MICHEL et al, 2013).…”

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confidence: 44%

Infecção pelo complexo Mycobacterium tuberculosis em carneiro da Barbária (Ammotragus lervia) no Zoológico de Curitiba, sul do Brasil: relato de caso

Morikawa

Biondo

Robes

et al. 2016

Braz. J. Vet. Res. Anim. Sci.

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A tuberculose é uma das doenças mundiais de notificação obrigatória mais importantes causada pelo complexo Mycobacterium tuberculosis que pode infectar pessoas e animais. A morte repentina de um carneiro da Barbária no Zoológico de Curitiba, que apresentou nódulos multifocais no pulmão à necropsia, levantou a suspeita de tuberculose. Foi realizada a Reação em Cadeia da Polimerase Quantitativa (qPCR) de fragmentos de órgãos e fluido. A qPCR detectou a presença do complexo M. tuberculosis nas amostras de pulmão. Este estudo relata a infecção pelo complexo M. tuberculosis no carneiro da Barbária, uma zoonose de grande relevância para a saúde pública, ressaltando-se a necessidade da implementação de medidas de prevenção. Além disso, pode prover um melhor entendimento sobre conservação de espécies, ocorrência e transmissão de doenças em cativeiro, potencial reservatório e impacto na saúde pública para visitantes e funcionários dos zoológicos.

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“…Veterinary practitioners regard tapirs to be the indicator species that may help diagnose bovine mycobacterium infection [22,23]. The conducted research showed that the tapirs described in the work did not have a tuberculin skin test done before being transferred to the Silesian zoo.…”

Section: Discussionmentioning

confidence: 99%

Tuberculosis in Polish Zoos as Health Risk for Humans

Krajewska‐Wędzina¹,

Augustynowicz–Kopeć²,

Weiner³

et al. 2017

hpc

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DETECTION OF RD^RIOSTRAIN OFMYCOBACTERIUM TUBERCULOSISIN TAPIRS (TAPIRUS TERRESTRIS) FROM A ZOO IN BRAZIL

Cited by 22 publications

References 10 publications

Tuberculosis Caused by Mycobacterium tuberculosis Complex in a Captive Tapir (Tapirus terrestris)

Tuberculosis Caused by Mycobacterium tuberculosis Complex in a Captive Tapir (Tapirus terrestris)

Infecção pelo complexo Mycobacterium tuberculosis em carneiro da Barbária (Ammotragus lervia) no Zoológico de Curitiba, sul do Brasil: relato de caso

Tuberculosis in Polish Zoos as Health Risk for Humans

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