Detection of Pulsation in Unruptured Cerebral Aneurysms by ECG-Gated 3D-CT Angiography (4D-CTA) with 320-Row Area Detector CT (ADCT) and Follow-up Evaluation Results: Assessment Based on Heart Rate at the Time of Scanning

Hayakawa, Masayuki; Tanaka, Teppei; Sadato, Akiyo; Adachi, Kazuhide; Ito, Keisuke; Hattori, Naoko; Omi, Tatsuo; Oheda, Motoki; Katada, Kazuhiro; Murayama, Kazuhiro; Kato, Yōkō; Hirose, Yuichi

doi:10.1007/s00062-013-0236-8

Cited by 37 publications

(24 citation statements)

References 21 publications

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“…as well as Ishida et al . also observed aneurysm wall motion and pulsating blebs in 4D-CTA data 9 , 10 , 14 , 15 . During surgery, wall motion positions could even be confirmed to be aneurysm rupture sites for two patients 10 and pulsating blebs as rupture points 9 .…”

Section: Cerebral Aneurysm Wall Motion Quantification: Overview Of Resupporting

confidence: 54%

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Analysis of the influence of imaging-related uncertainties on cerebral aneurysm deformation quantification using a no-deformation physical flow phantom

Schetelig

Sedlacik

Fiehler

et al. 2018

Sci Rep

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Cardiac-cycle related pulsatile aneurysm motion and deformation is assumed to provide valuable information for assessing cerebral aneurysm rupture risk. Accordingly, numerous studies addressed quantification of cerebral aneurysm wall motion and deformation. Most of them utilized in vivo imaging data, but image-based aneurysm deformation quantification is subject to pronounced uncertainties: unknown ground-truth deformation; image resolution in the order of the expected deformation; direct interplay between contrast agent inflow and image intensity. To analyze the impact of the uncertainties on deformation quantification, a multi-imaging modality ground-truth phantom study is performed. A physical flow phantom was designed that allowed simulating pulsatile flow through a variety of modeled cerebral vascular structures. The phantom was imaged using different modalities [MRI, CT, 3D-RA] and mimicking physiologically realistic flow conditions. Resulting image data was analyzed by an established registration-based approach for automated wall motion quantification. The data reveals severe dependency between contrast media inflow-related image intensity changes and the extent of estimated wall deformation. The study illustrates that imaging-related uncertainties affect the accuracy of cerebral aneurysm deformation quantification, suggesting that in vivo imaging studies have to be accompanied by ground-truth phantom experiments to foster data interpretation and to prove plausibility of the applied image analysis algorithms.

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Section: Cerebral Aneurysm Wall Motion Quantification: Overview Of Resupporting

confidence: 54%

“… 22 4D-CTA 0.23 mm 19/19 0.17 ± 0.10 mm e registration Hayakawa et al . 15 4D-CTA 0.5 mm 20/56 no visual inspection Illies et al . 18 4D-CTA 0.39 mm yes yes semi-automatic, threshold-based The studies are listed in chronological order.…”

Section: Cerebral Aneurysm Wall Motion Quantification: Overview Of Rementioning

confidence: 99%

Analysis of the influence of imaging-related uncertainties on cerebral aneurysm deformation quantification using a no-deformation physical flow phantom

Schetelig

Sedlacik

Fiehler

et al. 2018

Sci Rep

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“…It has the ability to separate different blood flow phases and can identify aneurysms previously difficult to distinguish from surrounding vessels, such as in the case of intranidal aneurysms associated with arteriovenous malformations [23]. Additionally, specific features now discernible on electrocardiogram-gated 4D-CTA can detect aneurysm pulsations with the cardiac cycle and are currently being investigated for higher risk of growth and rupture [24]. Another recent development involves the use of computational fluid dynamics, which seeks to simulate blood flow within the aneurysm to calculate variables that would presumably correlate with rupture risk such as aneurysmal wall shear stress and peak wall tension.…”

Section: Current Developmentsmentioning

confidence: 99%

Imaging of cerebral aneurysms: a clinical perspective

et al. 2016

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Neuroimaging is a critical element in evaluating and treating patients with cerebral aneurysms. Each neuroimaging technique has unique strengths, weaknesses, and current developments. In this review, we discuss the utility of two primary noninvasive radiological techniques-computed tomography angiography (CTA) and magnetic resonance angiography (MRA)-as well as of digital subtraction angiography (DSA) for evaluation of cerebral aneurysms. These techniques allow comprehensive evaluation of aneurysm size, location, rupture status, and other imaging characteristics that guide clinicians to make appropriate and timely treatment recommendations.

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“…It can thus provide wide-range 3D images without moving the patient’s bed and can generate 4D images of the same position continuously or intermittently. Therefore, it is of great significance in the evaluation of cardiovascular disease [3], dysphagia [4, 5], and cerebrovascular disease [6, 7].…”

Section: Introductionmentioning

confidence: 99%

Velopharyngeal closure analysis using four-dimensional computed tomography: a pilot study of healthy volunteers and adult patients with cleft palate

et al. 2019

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Background Nasopharyngoscopy is a common method to evaluate velopharyngeal closure in patients with cleft palate. However, insertion of a fiberoptic nasopharyngoscope causes discomfort in patients. The aim of this study was to estimate the reliability of short-time exposure images obtained using 320-row area detector computed tomography (320-ADCT) as a novel evaluation method for the assessment of velopharyngeal function. Methods We evaluated five healthy adult volunteers and five postoperative adult patients with cleft palate. During a 3.3-s imaging exposure, the participants were asked to perform two tasks: nasal inspiration and subsequent oral expiration through a catheter into a water-filled cup. The movement of the velopharyngeal structures was recorded during each examination, and the presence of velopharyngeal insufficiency (VPI) and velopharyngeal closure (VPC) patterns were estimated. If VPI was detected, the cross-sectional area was also calculated. Cohen’s kappa and weighted kappa coefficients were used to evaluate the concordance of nasopharyngoscopy and 320-ADCT evaluation. Results Speech pathology evaluation did not reveal hypernasality in any study participant. Micro-VPI was detected by nasopharyngoscopy in one healthy volunteer and two patients. 320-ADCT detected micro-VPI in two more patients. The cross-sectional area of the VPI in these subjects ranged from 2.53 to 16.28 mm 2 . Nasopharyngoscopy and 320-ADCT were concordant in detecting VPI in eight participants (κ = 0.6) and in assessing VPC patterns in nine (κ = 0.82). Moreover, images obtained using 320-ADCT allowed for reduced dead angle and, thus, easy detection of micro-VPI and Passavant’s ridges. Conclusion Although the radiation exposure cannot be ignored, our novel evaluation method using 320-ADCT enables more detailed evaluation of VPC than nasopharyngoscopy. Future studies should investigate the relationship between 320-ADCT findings and speech pathology evaluations. Electronic supplementary material The online version of this article (10.1186/s12880-019-0350-4) contains supplementary material, which is available to authorized users.

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Detection of Pulsation in Unruptured Cerebral Aneurysms by ECG-Gated 3D-CT Angiography (4D-CTA) with 320-Row Area Detector CT (ADCT) and Follow-up Evaluation Results: Assessment Based on Heart Rate at the Time of Scanning

Abstract: Unruptured aneurysms in which pulsation was detected by 4D-CTA were more likely to show a change in shape at follow-up, suggesting that 4D-CTA may be useful for identifying aneurysms with a higher risk of rupture.

Cited by 37 publications

References 21 publications

Analysis of the influence of imaging-related uncertainties on cerebral aneurysm deformation quantification using a no-deformation physical flow phantom

Analysis of the influence of imaging-related uncertainties on cerebral aneurysm deformation quantification using a no-deformation physical flow phantom

Imaging of cerebral aneurysms: a clinical perspective

Velopharyngeal closure analysis using four-dimensional computed tomography: a pilot study of healthy volunteers and adult patients with cleft palate

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