Detection of prostate cancer using a voltammetric electronic tongue

Pascual, Lluı́s; Campos, Inmaculada; Vivancos, José-Luis; Quintás, Guillermo; Loras, Alba; Martínez-Bisbal, M. Carmen; Martínez‐Máñez, Ramón; Boronat, F; Ruiz-Cerdá, J.L.

doi:10.1039/c6an01044j

Cited by 17 publications

(10 citation statements)

References 31 publications

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“…It is likely that retesting it in a pure and larger population of spontaneous effusions would disclose better clinimetric properties. Secondly, we performed the voltammetric analysis according to the methods previously developed for the diagnosis of skin and bladder infections [5][6][7][8][9] . However, this might not be the best option for identifying a neoplastic pleural effusion.…”

Section: Discussionmentioning

confidence: 99%

“…This system has been used to measure different biological samples (urine, exudates collected from cutaneous ulcers) with promising results. VA can detect levels of uremic toxins 5 , urinary creatinine and the severity of renal insufficiency; it also allows to discriminate urine of healthy subjects from urine of patients with benign or malignant bladder 6 and prostate tumors 7 . Furthermore, it has been confirmed that VA is a powerful technique to diagnose UTI 8 .…”

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confidence: 99%

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Integration of voltammetric analysis, protein electrophoresis and pH measurement for diagnosis of pleural effusions: a non-conventional diagnostic approach

Pipita

Santonico

Pennazza

et al. 2020

Sci Rep

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Pleural effusion is very common, but an etiologic diagnosis is often difficult. We used three unconventional diagnostic techniques (voltammetric analysis, protein electrophoresis and pH measurement) performed on pleural effusion to do a preliminary distinction between a neoplastic and a non-neoplastic origin. Pleural fluid samples were collected through thoracentesis, thoracoscopy, or post-surgery pleural drainage of 116 patients admitted to acute care wards. Samples were analyzed with the three unconventional techniques: voltammetric analysis using the BIONOTE system, capillary electrophoresis and pH measurement using a potentiometric method. The BIONOTE system is an innovative system that performs a cyclic voltammetric analysis of a biological liquid sample. The final output of the electrochemical analysis is an electrical pattern that represents a fingerprint of the analyzed sample and each sample has a different fingerprint. Data from the three unconventional diagnostic techniques were analyzed using partial least squares discriminant analysis to discriminate neoplastic from non-neoplastic effusions; we also evaluated sensitivity, specificity and percentage of correct classification. The mean age was 68 years (SD: 12); 78 (67.24%) participants were men. Results obtained from all the unconventional techniques employed showed that neoplastic and non-neoplastic pleural effusions were correctly classified in 80.2% of cases, with a sensitivity of 77% and specificity of 83%. The combined use of voltammetric analysis, protein electrophoresis and pH measurement of pleural fluid can easily and quickly distinguish a neoplastic from a non-neoplastic pleural effusion with reliable accuracy and represents an innovative diagnostic approach. In fact, this protocol can be executed in just few minutes directly in the patient's bed and it holds great promise to improve the prognosis and therapeutic chances.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Integration of voltammetric analysis, protein electrophoresis and pH measurement for diagnosis of pleural effusions: a non-conventional diagnostic approach

Pipita

Santonico

Pennazza

et al. 2020

Sci Rep

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“…A set of potential pulses is applied to different metallic electrodes and the resulting current is sampled; the current data are then processed using multivariate analysis tools. Analyses of food stuff [33], water quality [34], wines [35] and urine for disease detection [36] and sensing of explosive material [37] are some of the applications of this type of electronic tongues. On the other hand, electrical impedance spectroscopy (EIS) is a very powerful analytical tool.…”

Section: Introductionmentioning

confidence: 99%

Microalgae degradation follow up by voltammetric electronic tongue, impedance spectroscopy and NMR spectroscopy

Martínez-Bisbal

Mestre

Martínez‐Máñez

et al. 2019

Sensors and Actuators B: Chemical

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“…A voltammetric MSS comprising seven working electrodes (Ir, Rh, Pt, Au, Ag, Co, and Cu) versus saturated calomel reference electrodes was applied to detect patients with prostate cancer (PCa) [64]. The sample set comprised 114 samples: 71 samples from the patients with PCa before surgical treatment and 43 controls (26 from patients who underwent the surgery and 17 from individuals with benign prostatic hyperplasia).…”

Section: Medical Analysismentioning

confidence: 99%

Electronic Tongues for Inedible Media

Kirsanov

Corrêa

Gaál

et al. 2019

Sensors

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“Electronic tongues”, “taste sensors”, and similar devices (further named as “multisensor systems”, or MSS) have been studied and applied mostly for the analysis of edible analytes. This is not surprising, since the MSS development was sometimes inspired by the mainstream idea that they could substitute human gustatory tests. However, the basic principle behind multisensor systems—a combination of an array of cross-sensitive chemical sensors for liquid analysis and a machine learning engine for multivariate data processing—does not imply any limitations on the application of such systems for the analysis of inedible media. This review deals with the numerous MSS applications for the analysis of inedible analytes, among other things, for agricultural and medical purposes.

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Detection of prostate cancer using a voltammetric electronic tongue

Cited by 17 publications

References 31 publications

Integration of voltammetric analysis, protein electrophoresis and pH measurement for diagnosis of pleural effusions: a non-conventional diagnostic approach

Integration of voltammetric analysis, protein electrophoresis and pH measurement for diagnosis of pleural effusions: a non-conventional diagnostic approach

Microalgae degradation follow up by voltammetric electronic tongue, impedance spectroscopy and NMR spectroscopy

Electronic Tongues for Inedible Media

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