Detection of Prostate Cancer by an Electronic Nose: A Proof of Principle Study

Roine, Antti; Veskimäe, Erik; Tuokko, Antti; Kumpulainen, Pekka; Koskimäki, Juha; Keinänen, Tuomo A.; Häkkinen, Merja R.; Vepsäläinen, Jouko; Paavonen, Timo; Lekkala, Jukka; Lehtimäki, Terho; Tammela, Teuvo L.J.; Oksala, Niku

doi:10.1016/j.juro.2014.01.113

Cited by 71 publications

(76 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The following sections provide an overview of the state-of-the-art of the application of electronic noses for the analysis of urine samples by classifying those applications depending on the target investigated, thus including the discrimination of bacteria cultures (Section 2.2) [49,50,51,52], or the detection of urinary tract infections (Section 2.3) [53,54,55,56,57,58], cancer diseases (Section 2.4) [59,60,61,62,63,64,65,66], diabetes (Section 2.5) [67,68], kidney diseases (Section 2.6) [69,74], bowel diseases (Section 2.7) [70,71,72] and exposure to toxic agents (Section 2.8) [73] (reference [74] wasn’t included in Table 1 since it refers to breath analysis).…”

Section: Electronic Noses For Urine Sample Analysismentioning

confidence: 99%

See 1 more Smart Citation

Application and Uses of Electronic Noses for Clinical Diagnosis on Urine Samples: A Review

Capelli

Taverna

Bellini

et al. 2016

Sensors

View full text Add to dashboard Cite

The electronic nose is able to provide useful information through the analysis of the volatile organic compounds in body fluids, such as exhaled breath, urine and blood. This paper focuses on the review of electronic nose studies and applications in the specific field of medical diagnostics based on the analysis of the gaseous headspace of human urine, in order to provide a broad overview of the state of the art and thus enhance future developments in this field. The research in this field is rather recent and still in progress, and there are several aspects that need to be investigated more into depth, not only to develop and improve specific electronic noses for different diseases, but also with the aim to discover and analyse the connections between specific diseases and the body fluids odour. Further research is needed to improve the results obtained up to now; the development of new sensors and data processing methods should lead to greater diagnostic accuracy thus making the electronic nose an effective tool for early detection of different kinds of diseases, ranging from infections to tumours or exposure to toxic agents.

show abstract

Section: Electronic Noses For Urine Sample Analysismentioning

confidence: 99%

“…Roine et al [65] evaluated electronic nose performance in discriminating PC from BPH using urine headspace. Urine samples were collected from patients with confirmed prostate cancer and from patients with BPH.…”

Section: Electronic Noses For Urine Sample Analysismentioning

confidence: 99%

Application and Uses of Electronic Noses for Clinical Diagnosis on Urine Samples: A Review

Capelli

Taverna

Bellini

et al. 2016

Sensors

View full text Add to dashboard Cite

show abstract

“…10 VOCs have been found in feces, urine, headspace of microorganism cultures, and exhaled breath. The compounds have been associated with respiratory, 11 urogenital, 12 and neurological disease, 13 as well as with malignancies of the lung, 14,15 colorectal, 14,16 and head and neck origin. 14,[17][18][19][20] The present study used an Aeonose (The eNose Company, Zutphen, the Netherlands), a low-cost, rapid, portable, handheld, and noninvasive diagnostic tool for VOC pattern recognition in breath samples.…”

Section: Introductionmentioning

confidence: 99%

Detecting recurrent head and neck cancer using electronic nose technology: A feasibility study

et al. 2019

View full text Add to dashboard Cite

Background The aim of this feasibility study was to assess the diagnostic performance of an electronic nose (e‐nose) as a noninvasive diagnostic tool in detecting locoregional recurrent and/or second (or third) primary head and neck squamous cell carcinoma (HNSCC) after curative treatment. Methods Using an e‐nose (Aeonose, The eNose Company, Zutphen, The Netherlands), breath samples were collected from patients after curative treatment of an HNSCC with a locoregional recurrence or second (or third) primary tumor (N = 20) and from patients without evidence of recurrent disease (N = 20). Analyses were performed utilizing artificial neural networking based on patterns of volatile organic compounds. Results A diagnostic accuracy of 83% was observed in differentiating follow‐up patients with locoregional recurrent or second (or third) primary HNSCC from those without evidence of disease. Conclusion This study has demonstrated the feasibility of using an e‐nose to detect locoregional recurrent and/or second (or third) primary HNSCC.

show abstract

“…The idea of using a complex mixture of small urine compounds to assay for PCa is the basis of metabolomics in its holistic approach. Interestingly, even organic compounds evaporated from urine can be used for PCa discrimination from BPH by using unspecific multisensor ion mobility spectrometry, supporting the notion of disease-specific urine metabolite composition (Roine et al, 2014). We performed a PubMed search focusing on urine NMR metabolomics and summarized the most relevant papers in Table 2.…”

Section: Urinementioning

confidence: 86%

Nuclear magnetic resonance spectroscopy as a new approach for improvement of early diagnosis and risk stratification of prostate cancer

Yang

Lü

Wen

et al. 2017

J. Zhejiang Univ. Sci. B

View full text Add to dashboard Cite

Prostate cancer (PCa) is the second most common male cancer worldwide and the fifth leading cause of death from cancer in men. Early detection and risk stratification is the most effective way to improve the survival of PCa patients. Current PCa biomarkers lack sufficient sensitivity and specificity to cancer. Metabolite biomarkers are evolving as a new diagnostic tool. This review is aimed to evaluate the potential of metabolite biomarkers for early detection, risk assessment, and monitoring of PCa. Of the 154 identified publications, 27 and 38 were original papers on urine and serum metabolomics, respectively. Nuclear magnetic resonance (NMR) is a promising method for measuring concentrations of metabolites in complex samples with good reproducibility, high sensitivity, and simple sample processing. Especially urine-based NMR metabolomics has the potential to be a cost-efficient method for the early detection of PCa, risk stratification, and monitoring treatment efficacy.

show abstract

Detection of Prostate Cancer by an Electronic Nose: A Proof of Principle Study

Abstract: The electronic nose is capable of rapidly and noninvasively discriminating prostate cancer and benign prostatic hyperplasia using urine headspace in patients undergoing surgery.

Cited by 71 publications

References 27 publications

Application and Uses of Electronic Noses for Clinical Diagnosis on Urine Samples: A Review

Application and Uses of Electronic Noses for Clinical Diagnosis on Urine Samples: A Review

Detecting recurrent head and neck cancer using electronic nose technology: A feasibility study

Nuclear magnetic resonance spectroscopy as a new approach for improvement of early diagnosis and risk stratification of prostate cancer

Contact Info

Product

Resources

About