Detection of pathological changes in the architectonics of polycrystalline blood films using laser-induced polarization interferometry

Kvasnyuk, D.; Trifonyuk, L.; Strashkevich, A.M.; Kozan, N. M.; Ушенко, В. А.; Dunaiev, O.; Kryvetskiy, V; Oliinyk, I. Yu.; Kurek, E. I.; Tkachuk, V. I.

doi:10.1117/12.2616837

Cited by 1 publication

(4 citation statements)

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“…The resulting set of optical anisotropy maps

was analyzed in a statistical approach using the following algorithms to calculate mean (

), variance (

), skewness (

) and kurtosis (

) [ 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ]

where

—CCD pixels quantity.…”

Section: Statistical Analysis Of Maps Of Linear and Circular Birefrin...mentioning

confidence: 99%

“…Polarimetric studies of the polarization manifestations of BF anisotropy make it possible to detect pathological changes in the quaternary and tertiary polycrystalline structure of basic proteins (albumin and globulin) in blood plasma and other biological fluids, which are inaccessible in the most common biochemical methods. In a series of works [ 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ], the sensitivity of polarimetric methods to inflammatory, pathological and necrotic changes in the polycrystalline structure of films of blood plasma, urine, synovial fluid, and cerebrospinal fluid was demonstrated.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the potential of the Jones matrix tomography technique can be expanded to other equally relevant areas, such as instrumental medical diagnostics COVID-19 [ 51 , 52 , 53 ]…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the potential of the Jones matrix tomography technique can be expanded to other equally relevant areas, such as instrumental medical diagnostics COVID-19 [51][52][53] Our work aims to create and validate a new experimental method of polarization interference multilayer Jones matrix scanning of the polycrystalline structure of blood plasma (BPF) and saliva (SF) for diagnosis and differentiation of prostate cancer stages.…”

mentioning

confidence: 99%

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Optical Sensor System for 3D Jones Matrix Reconstruction of Optical Anisotropy Maps of Self-Assembled Polycrystalline Soft Matter Films

Wójcik,

Hu,

Ushenko

et al. 2024

Sensors

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Our work uses a polarization matrix formalism to analyze and algorithmically represent optical anisotropy by open dehydration of blood plasma films. Analytical relations for Jones matrix reconstruction of optical birefringence maps of protein crystal networks of dehydrated biofluid films are found. A technique for 3D step-by-step measurement of the distributions of the elements of the Jones matrix or Jones matrix images (JMI) of the optically birefringent structure of blood plasma films (BPF) has been created. Correlation between JMI maps and corresponding birefringence images of dehydrated BPF and saliva films (SF) obtained from donors and prostate cancer patients was determined. Within the framework of statistical analysis of layer-by-layer optical birefringence maps, the parameters most sensitive to pathological changes in the structure of dehydrated films were found to be the central statistical moments of the 1st to 4th orders. We physically substantiated and experimentally determined the sensitivity of the method of 3D polarization scanning technique of BPF and SF preparations in the diagnosis of endometriosis of uterine tissue.

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“…The resulting set of optical anisotropy maps

was analyzed in a statistical approach using the following algorithms to calculate mean (

), variance (

), skewness (

) and kurtosis (

) [ 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ]

where

—CCD pixels quantity.…”

Section: Statistical Analysis Of Maps Of Linear and Circular Birefrin...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…In addition, the potential of the Jones matrix tomography technique can be expanded to other equally relevant areas, such as instrumental medical diagnostics COVID-19 [ 51 , 52 , 53 ]…”

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations