Detection of pandemic influenza-A(H1N1)-2009 virus in urine

Ho, Yeh‐Li; Yoshino, Alessandra; Tonacio, Adriana Coracini; Latif, Acram Zahredine Abdul; Filho, H H Caiaffa; Santos, Suelen Silvana dos

doi:10.1007/s00134-013-2921-0

Cited by 6 publications

(6 citation statements)

References 5 publications

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“…Influenza. We identified 37 articles (15,19,(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(52)(53)(54)(55)(56) with data on influenza in patient excretions; these articles contained 77 influenza data sets. Seventy-six of the data sets were generated using RT-PCR and the remaining one used culture methods (19).…”

Section: Systematic Review Resultsmentioning

confidence: 99%

“…reported cross-sectional positivity rate data from between one (24,28,45,46) and 120 (54) subjects with confirmed influenza infections.…”

Section: Systematic Review Resultsmentioning

confidence: 99%

“…Seventy-six of the data sets were generated using RT-PCR and the remaining one used culture methods (19). Eight of the 77 data sets reported longitudinal shedding data (of these 8, two reported positivity rates (55), and six reported concentrations (44)), 10 reported concentration data from cross-sectional studies (38,40,41,44), and the remaining 59 reported cross-sectional positivity rate data from between one (24,28,45,46) and 120 (54) subjects with confirmed influenza infections.…”

Section: Resultsmentioning

confidence: 99%

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Respiratory virus concentrations in human excretions that contribute to wastewater: A systematic review

Lowry

Wolfe

Boehm

2023

Preprint

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Concentrations of nucleic acids from a range of respiratory viruses including human influenza A and B, respiratory syncytial virus (RSV), metapneumovirus, parainfluenza virus, rhinovirus, and seasonal coronaviruses in wastewater solids collected from wastewater treatment plants correlate to clinical data on disease occurrence in the community contributing to the wastewater. Viral nucleic acids enter wastewater from various excretions including stool, urine, mucus, sputum, and saliva deposited in toilets or other drains in buildings. In order to relate the measured concentrations in wastewater at a treatment plant to actual number of infections in a community, concentrations of the viral nucleic acids in these human excretions are needed as inputs to a mass balance model. In this study, we carried out a systematic review and meta-analysis to characterize the concentrations and presence of influenza A and B, respiratory syncytial virus (RSV), metapneumovirus, parainfluenza virus, rhinovirus, and seasonal coronaviruses in stool, urine, mucus, sputum, and saliva. The systematic review protocol can be accessed at https://doi.org/10.17605/OSF.IO/ESVYC. We identified 220 data sets from 50 unique articles that met inclusion criteria and reported information on viral concentrations and presence in these excretions. Data were unevenly distributed across virus type (with the most available for influenza) and excretion type (with the most available for respiratory excretions). The majority of data sets only reported the presence or absence of the virus in an excretion in a cross-sectional study design. There is a need for more concentration data, including longitudinal data, across all respiratory virus and excretion types. Such data would allow quantitatively linking virus wastewater concentrations to numbers of infected individuals.

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Section: Systematic Review Resultsmentioning

confidence: 99%

“…reported cross-sectional positivity rate data from between one (24,28,45,46) and 120 (54) subjects with confirmed influenza infections.…”

Section: Systematic Review Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Respiratory virus concentrations in human excretions that contribute to wastewater: A systematic review

Lowry

Wolfe

Boehm

2023

Preprint

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“…However, the entry route is not known. Active replication of the H1N1 virus in distal tubular epithelial cells, cell necrosis and shedding, 8 and detection of the H1N1 virus in urine 9 have been reported. Such evidence suggests that the H1N1 virus may trigger AKI by destroying the distal tubules, making it critical to understand the pathogenesis of the H1N1 virus infection of the distal tubules.…”

Section: Introductionmentioning

confidence: 98%

Distal renal tubular system-on-a-chip for studying the pathogenesis of influenza A virus-induced kidney injury

Huangfu,

Wang,

Feng

et al. 2023

Lab Chip

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“…Notably, human and avian IAV receptors are present in human kidney cells ( Ulloa and Real, 2001 ; Yao et al., 2008 ), and—in addition to liver, spleen, heart, and muscle—infectious IAV has been isolated from kidney tissue in human autopsies ( Kaji et al., 1959 ; Gamboa et al., 1979 ). Furthermore, IAV could be detected in the urine of patients during several pandemic outbreaks ( Figure 1 ) ( Zakstel’, 1953 ; Khakpour and Nik-Akhtar, 1977 ; Abdulkader et al., 2010 ; To et al., 2010 ; Ho et al., 2013 ). A recent meta-analysis showed that the rate of positive urine tests for IAV was 58% in patients infected with IAV ( Lowry et al., 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Influenza A virus replicates productively in primary human kidney cells and induces factors and mechanisms related to regulated cell death and renal pathology observed in virus-infected patients

Koch,

Shehata,

Müller-Ruttloff

et al. 2024

Front. Cell. Infect. Microbiol.

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IntroductionInfluenza A virus (IAV) infection can cause the often-lethal acute respiratory distress syndrome (ARDS) of the lung. Concomitantly, acute kidney injury (AKI) is frequently noticed during IAV infection, correlating with an increased mortality. The aim of this study was to elucidate the interaction of IAV with human kidney cells and, thereby, to assess the mechanisms underlying IAV-mediated AKI.MethodsTo investigate IAV effects on nephron cells we performed infectivity assays with human IAV, as well as with human isolates of either low or highly pathogenic avian IAV. Also, transcriptome and proteome analysis of IAV-infected primary human distal tubular kidney cells (DTC) was performed. Furthermore, the DTC transcriptome was compared to existing transcriptomic data from IAV-infected lung and trachea cells.ResultsWe demonstrate productive replication of all tested IAV strains on primary and immortalized nephron cells. Comparison of our transcriptome and proteome analysis of H1N1-type IAV-infected human primary distal tubular cells (DTC) with existing data from H1N1-type IAV-infected lung and primary trachea cells revealed enrichment of specific factors responsible for regulated cell death in primary DTC, which could be targeted by specific inhibitors.DiscussionIAV not only infects, but also productively replicates on different human nephron cells. Importantly, multi-omics analysis revealed regulated cell death as potential contributing factor for the clinically observed kidney pathology in influenza.

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Detection of pandemic influenza-A(H1N1)-2009 virus in urine

Cited by 6 publications

References 5 publications

Respiratory virus concentrations in human excretions that contribute to wastewater: A systematic review

Respiratory virus concentrations in human excretions that contribute to wastewater: A systematic review

Distal renal tubular system-on-a-chip for studying the pathogenesis of influenza A virus-induced kidney injury

Influenza A virus replicates productively in primary human kidney cells and induces factors and mechanisms related to regulated cell death and renal pathology observed in virus-infected patients

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