Detection of Osteopontin in the pericyst of human hepatic Echinococcus granulosus

Peng, Xinyu; Wu, Xiangwei; Zhang, Shijie; Niu, Jianhua; Chen, Xiaoping; Ye, Jin; Sun, Hong

doi:10.1016/j.actatropica.2006.08.013

Cited by 40 publications

(27 citation statements)

References 16 publications

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“…fibrosis/necrosis and bile duct and vessel obstruction (14,15). Eosinophils degranulate at the host-Echinococcus interface, and eosinophil cationic protein, a major component of eosinophil granules, reaches levels in hydatid cyst fluid harmful to the parasite (16).…”

Section: Figurementioning

confidence: 99%

Mechanisms of Immunity in Hydatid Disease: Implications for Vaccine Development

Zhang

Ross

McManus

2008

The Journal of Immunology

126

116

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The Echinococcus organisms, the cause of echinococcosis (hydatid disease), are parasitic helminths with life cycles involving a carnivorous definitive host (usually dog or fox) and an intermediate host (human, ungulate, or rodent). They are complex multicellular pathogens that, despite being under constant barrage by the immune system, are able to modulate antiparasite immune responses and persist and flourish in their mammalian hosts. Understanding how the immune system deals with these parasites is a major challenge. Recent application of modern molecular and immunological approaches has revealed insights on the nature of immune responses generated during the course of hydatid infection, although many aspects of the Echinococcus-host interplay remain unexplored. This review summarizes current understanding of the immunology of echinococcosis, indicates areas where information is lacking, and shows how knowledge of host protective immunity has been translated into the design and development of anti-Echinococcus vaccines for application in intermediate hosts.

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Section: Figurementioning

confidence: 99%

Mechanisms of Immunity in Hydatid Disease: Implications for Vaccine Development

Zhang

Ross

McManus

2008

The Journal of Immunology

126

116

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“…Cellular infiltration of eosinophils, neutrophils, macrophages, and fibrocytes occurs in humans (Magambo et al, 1995;Peng et al, 2006) and sheep (Petrova, 1968) infections. However, this generally does not result in a severe inflammatory response and aged cysts tend to become surrounded by a fibrous layer that separates the laminated cystic layer from host tissue.…”

Section: T Cell Responsesmentioning

confidence: 99%

Recent Advances in the Immunology and Serological Diagnosis of Echinococcosis

Zhang¹,

Li²,

Lin³

et al. 2012

Serological Diagnosis of Certain Human, Animal and Plant Diseases

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“…However, Peng et al (2006) reported the existence of a fibrous membrane between the cyst and the liver parenchyma in LHC patients. The fibrous capsule around a hepatic hydatid cyst is a granuloma-like structure covered by the compressed Glisson and hepatic vein systems, with a small gap between them, and the fibrous membrane and the fibrous capsule have been shown to have different mechanisms of formation (Peng et al, 2004a) (Fig.…”

Section: Introductionmentioning

confidence: 95%