Detection of opium alkaloids in a Cypriot base-ring juglet

Smith, Rachel K.; Stacey, Rebecca; Bergström, Edmund T.; Thomas‐Oates, Jane

doi:10.1039/c8an01040d

Cited by 19 publications

(18 citation statements)

References 22 publications

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“…The structural formulas of morphine, thebaine, and narcotine are shown in Figure S2. It should be mentioned that the decomposition and oxidation products of the main components of opium could be found in fairly old samples of opium …”

Section: Resultsmentioning

confidence: 99%

“…It should be mentioned that the decomposition and oxidation products of the main components of opium could be found in fairly old samples of opium. 41 Taking this into account, we considered the ATBDI mass spectra of an aqueous solution of opium (Figure 6a). Among others, the peaks at m/z 286, 300, 312, 340, and 414 were found, and they were attributed to protonated morphine, codeine, thebaine, papaverine, and narcotine, respectively.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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Aerodynamic Thermal Breakup Droplet Ionization in Mass Spectrometric Drug Analysis

Pervukhin

Sheven

2020

J. Am. Soc. Mass Spectrom.

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Aerodynamic thermal breakup droplet ionization (ATBDI) in mass spectrometric drug analysis is considered. Cocaine, heroin, and the main alkaloids of opium (morphine, codeine, papaverine) were chosen as the test compounds. The principles of ATBDI ionization are discussed. The dependences of the intensities of the peaks of the target compounds on temperature during ATBDI ionization are also considered. In some cases, a comparison of ATBDI ionization with electrospray ionization (ESI) was performed. In addition, a comparison of methods is demonstrated by the analysis of confiscated opium that was provided by the local police department. Five major alkaloids are found in opium: morphine, codeine, thebaine, papaverine, and narcotine.

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Section: Resultsmentioning

confidence: 99%

Section: ■ Results and Discussionmentioning

confidence: 99%

Aerodynamic Thermal Breakup Droplet Ionization in Mass Spectrometric Drug Analysis

Pervukhin

Sheven

2020

J. Am. Soc. Mass Spectrom.

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“…Organic molecules were extracted from samples of about 500 mg following the methods in Smith et al (2018), with some modifications which were necessary to allow alkaloid analysis by GC-MS (gas chromatography-mass spectrometry). All solvents and reagents were analytical grade, typically > 98% purity.…”

Section: Biochemical Profilingmentioning

confidence: 99%

“…Shape, archaeological context and association with other items are the main elements to suggest the uses of pottery (Evershed 1993;Eerkens 2007;Radford 2019). However, in the last few decades, new analytical approaches such as the use of chromatography for studying the organic residues preserved in archaeological artefacts have provided data on human activities as quantitative and qualitative results (Evershed 1993;Eerkens 2007;McGovern and Hall 2016;Dunne et al 2017;Luong et al 2017Luong et al , 2018Roffet-Salque et al 2017;Smith et al 2018;Radford 2019;Demirci et al 2020;Pecci et al 2020). One of the most critical issues in such types of investigation is the degradation process which affects biomolecules (Whelton et al 2021).…”

Section: Introductionmentioning

confidence: 99%

Exploring prehistoric plant use by molecular analyses of Neolithic grave goods

D’Agostino

Marco

Rolfo

et al. 2023

Veget Hist Archaeobot

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At the site of Grotta Mora Cavorso (Lazio, Italy), an unusual archaeological find, made of two coarse pottery vessels, was recovered from burial levels radiocarbon dated to 6,405–6,275 bp. These artefacts were analysed using several methods, for interpretation of the cultural practices of the earliest inhabitants in central Italy. This first molecular evidence about the potential processing and storage of poppy-based products in Neolithic pottery was obtained by detecting ancient DNA (aDNA) and chemical compounds. This study represents the second evidence from the Mediterranean area of the use of Papaver L. (poppies), although the actual use(s) of these plants then, for example as sedatives, drugs, or food, remains uncertain. Also, the employment of Olea europaea L. (olive) derivatives in foods or for other purposes was suggested, in agreement with the recovery of fruit stones at the site. The results of the present archaeobotanical investigation show the environmental knowledge of the first prehistoric communities living in central Italy, who might have shared their ethnobotanical practices.

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“…121 In general, the consumption of psychoactive substances in the ancient Mediterranean world, though often suspected, remains difficult to ascertain, as the case of the Bronze Age Cypriot base-ring 'opium' juglets illustrates. Long assumed to have contained opioid substances consumed for their psychoactive effect, recent analyses point rather towards poppy seed and other aromatic oils more suitable for medicinal applications: Bunimovitz and Lederman (2016); Chovanec (2018); Smith et al (2018).…”

Section: A Case For Cuisine: Food and Social Relationsmentioning

confidence: 99%

Spicing Wine at theSymposion:Fact or Fiction? Some Critical Thoughts on Material Aspects of Commensality in the Early Iron Age and Archaic Mediterranean World

Villing

2021

J. Hell. Stud.

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Interpretations of metal graters and pottery tripod bowls as Leitfossils of a trans-Mediterranean ‘orientalizing’ culture of spiced-wine consumption have of late become a staple of scholarship on sympotic banqueting, shaping our perception of ancient wine-drinking and its role in cross-cultural interaction in the first half of the first millennium BC. Yet a closer look at the evidence for spiced wine and the use of graters casts serious doubt on assumptions of a widespread practice of adding ‘spices’ to wine during the Greek symposion and of the use of graters or tripod grinding bowls for such a purpose in the Mediterranean and Near Eastern world. A more plausible scenario, it is argued, arises from the well-attested association of graters with cheese and other primarily culinary commodities. It sees the grater’s prime function and symbolic significance shift from a use in Early Iron Age ‘Homeric’ hospitality to becoming a tool in the increasingly complex cuisines associated with the Archaic and Classical banquet – an indicator of evolving Mediterranean commensality with no less of an international horizon, but a commensality that involved interaction and shared consumption beyond the narrowly sympotic.

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Detection of opium alkaloids in a Cypriot base-ring juglet

Abstract: The first rigorous chemical evidence supporting the controversial theory linking Bronze Age Cypriot base-ring juglets with the opium poppy.

Cited by 19 publications

References 22 publications

Aerodynamic Thermal Breakup Droplet Ionization in Mass Spectrometric Drug Analysis

Aerodynamic Thermal Breakup Droplet Ionization in Mass Spectrometric Drug Analysis

Exploring prehistoric plant use by molecular analyses of Neolithic grave goods

Spicing Wine at theSymposion:Fact or Fiction? Some Critical Thoughts on Material Aspects of Commensality in the Early Iron Age and Archaic Mediterranean World

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