“…Plasma protein profiling in mice with OE19 EAC xenografts that were treated with clinically relevant chemotherapeutic agents epirubicin, cisplatin, or 5-fluorouracil resulted in the identification of apolipoprotein A-1, serum amyloid A, and transthyretin as candidate biomarkers of response to chemotherapy [55]. However, although the results were confirmed in clinical samples, the number of patients with evident pathological response was relatively small; the biomarker pattern could not be compared with other indicators of clinical response and required further validation.…”