Detection of odorant molecules via surface acoustic wave biosensor array based on odorant-binding proteins

Smell Sensors Based on Odorant Binding Proteins

“…For mammal OBPs, such as bovine OBP and porcine OBP, they have already been studied in biosensors for odor detections, such as ethanol, octenol, and carvone, with high specificity and sensitivity [5,7,[17][18][19]. For insects, studies show that OBPs of honeybee and fruit fly could be used to detect floral odors, pheromones, and semiochemicals, in vitro [11,14,15,20].…”

“…However, their structures have their own characteristics. Vertebrate OBPs belong to a subclass of lipocalins and share a conserved folding pattern, such as eight antiparallel β-sheet and an α-helix at the C-terminal end [6,7]. Meanwhile, vertebrate OBPs exist as monomer or homodimer depending on OBPs.…”

“…Taking OBPs of mammals or insects as the sensing elements, different sensors, such as surface acoustic wave (SAW), quartz crystal microbalance (QCM), electrochemical impedance spectroscopy (EIS), surface plasmon resonance (SPR), and cantilever sensors, have already been developed [7,[11][12][13][14][15][16][17]. For mammal OBPs, such as bovine OBP and porcine OBP, they have already been studied in biosensors for odor detections, such as ethanol, octenol, and carvone, with high specificity and sensitivity [5,7,[17][18][19].…”

A surface acoustic wave bio-electronic nose for detection of volatile odorant molecules

“…In particular, we demonstrated the capability to detect different odorant molecules with a OBP-based SAW biosensor system (Di Pietrantonio et al, 2013). The SAW biosensors were coated by drop-casting of OBP containing solutions on the active area of the SAW sensors (Di Pietrantonio et al, 2013).…”

Sensor Arrays Based on Polycyclic Aromatic Hydrocarbons: Chemiresistors versus Quartz-Crystal Microbalance

“…[1][2][3][4][5] These arrays could meet the growing demand for rapid and flexible online detection of a wide range of chemical and biological agents in different branches of industry, homeland security, 5,6 environmental monitoring, 5,7,8 and medical diagnostics [1][2][3][4][5][9][10][11][12][13][14][15][16][17][18][19][20] . Combined with statistical algorithms, these sensor arrays can provide convenient bionics of the mammalian olfactory system for identifying complex gas samples, without the necessity of identifying their separate ingredients.…”