Detection of Novel apyrimidinic Endonuclease 1 (APE1) in a sample of Iraqi cervical cancer patients using Immunohistochemistry Technique

Al-Zwaini, Yasser Kadhim Hashem; Al-Mugdadi, Suhad Faisal Hatem; Abbas, Wassan Abdul Kareem

doi:10.5958/0974-360x.2020.00565.x

Cited by 4 publications

(1 citation statement)

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“…Eastern Africa [42.7], Melanesia [33.3], Southern [31.5], and Middle [30.6] Africa are high-risk locations with estimated ASRs of > 30 per 100,000. Australia/New Zealand [5.5%] and Western Asia [4.4%] have the lowest rates [7]. In Iraq, 10.74 million women between the ages of 15 and 64 are at risk of cervical cancer.…”

Section: Introductionmentioning

confidence: 99%

Detection of FOXP-3 Expression in a Sample of Iraqi Cervical Cancer Patients Using Immunohistochemistry Technique

Al-Zwaini

Al-Mugdadi

Abbas

2022

Iraqi Journal of Science

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This paper aims to find out if FOXP-3 was expressed in samples from Iraqi cervical cancer patients. Expression of FOXP-3 was detected in 55 cervical tissue samples by immunohistochemistry. Since thirty-five cases of aggressive cervical cancer were included, along with 20 normal samples used as controls. The nucleus and cytoplasm levels of FOXP-3 were counted, considering the ratio of positive cells and intensity. FOXP3 cytoplasmic staining was found in 27 out of 35 cases. Only 11 out of 35 samples displayed nuclear lymphocyte staining. Furthermore, four samples expressed this marker in both the nuclear and cytoplasm of the cervical cells. There is a highly significant difference in FOXP3 expression in the cytoplasm of malignant cells and lymphocytes compared to normal samples. Seven samples out of 11 cells correlated with lymph vascular invasion. These results show that tissue positive FOXP-3 possesses a possible diagnostic marker for Iraqi cervical cancer. FOXP3 is significantly expressed in cancer cells, and lymphocyte infiltrates [T-reg] compared to normal.

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Section: Introductionmentioning

confidence: 99%

Detection of FOXP-3 Expression in a Sample of Iraqi Cervical Cancer Patients Using Immunohistochemistry Technique

Al-Zwaini

Al-Mugdadi

Abbas

2022

Iraqi Journal of Science

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Carbon Nanomaterial-Based Biosensors: A Forthcoming Future for Clinical Diagnostics

Saini¹,

Pandey²,

Wankar³

et al. 2023

Materials Horizons: From Nature to Nanomaterials

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Effect of Zanthoxylum acanthopodium methanol extract on CDK4 expression to cervical cancer

Simanullang¹,

Hutahaean

Rosidah

et al. 2021

RJPT

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Cervical cancer is a disease from the Human papillomavirus (HPV) through transmission, virus persistence, clone development until infecting the cells in the cervical. This study is to determine CDK4 expression in cervical cancer cells after being given Zanthoxylum acanthopodium methanol extract (ZAM) and the histological description of cervical cancer cells. This study consisted of 5 treatment groups. K-: control group, K+: rats model of cancer, P1: rats model of cancer with a dose of 100mg/BW of ZAM, P2: rats model of cancer with a dose of 200 mg/BW of ZAM, and P3: rats model of cancer with a dose of 400 mg/BW of ZAM. The cervical tissue was prepared on paraffin blocks and given Immunohistochemistry staining. Results showed that the expression of CDK4 are reduced in the ZAM treatment at doses of 200 and 400mg/KgBW (P<0.05) in cervical histology, but in doses of 100mg/kg BW, many brown marks are still visible on the cervical tissue. These proteins will bind, inhibit proteins, cell cycle development, modulate cell division, and signal transduction pathways of apoptotic signaling. The injection of benzopyrene and given ZAM in cervical tissue affect hematological values. ZAM affects and improves cervical histology after benzopyrene injection. The extract of andaliman can be developed into a cervical cancer drug candidate.

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Detection of Novel apyrimidinic Endonuclease 1 (APE1) in a sample of Iraqi cervical cancer patients using Immunohistochemistry Technique

Cited by 4 publications

References 0 publications

Detection of FOXP-3 Expression in a Sample of Iraqi Cervical Cancer Patients Using Immunohistochemistry Technique

Detection of FOXP-3 Expression in a Sample of Iraqi Cervical Cancer Patients Using Immunohistochemistry Technique

Carbon Nanomaterial-Based Biosensors: A Forthcoming Future for Clinical Diagnostics

Effect of Zanthoxylum acanthopodium methanol extract on CDK4 expression to cervical cancer

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