Detection of non-palpable breast cancer in asymptomatic women by using unenhanced diffusion-weighted and T2-weighted MR imaging: comparison with mammography and dynamic contrast-enhanced MR imaging

Yabuuchi, Hidetake; Matsuo, Yoshio; Sunami, Shunya; Kamitani, Takeshi; Kawanami, Satoshi; Setoguchi, Taro; Sakai, Shuji; Hatakenaka, Masamitsu; Kubo, Makoto; Tokunaga, Eriko; Yamamoto, Hidetaka; Honda, Hiroshi

doi:10.1007/s00330-010-1890-8

Cited by 117 publications

(97 citation statements)

References 15 publications

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“…Use of DWI together with T2-weighted images created a good unenhanced imaging alternative to DCE-MRI in lesion detection and characterization. This method was previously used in some experimental clinical and reader studies and found to be useful for the diagnosis of breast cancer (24)(25)(26)(27). Lastly, Trimboli et al (28) reported 78% sensitivity and 87% specificity for breast cancer detection with unenhanced MRI of 67 women.…”

Section: Discussionmentioning

confidence: 98%

Can unenhanced breast MRI be used to decrease negative biopsy rates?

Kul

Oguz²,

Eyüboğlu³

et al. 2015

Diagn Interv Radiol

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T he Breast Imaging Reporting and Data Systems (BI-RADS) lexicon (1) of AmericanCollege of Radiology (ACR) provides an efficient and standardized assessment and management of breast lesions. It also stratifies breast cancer risk for a given lesion by classifying them into categories 1 through 5 according to the degree of suspicion.According to this system, solid masses with a circumscribed margin, oval shape (including those with two or three gentle lobulations) and parallel orientation on ultrasonography (US) exam are classified as BI-RADS 3. These types of masses are commonly seen at diagnostic and screening examinations. In this category malignancy is highly unlikely (less than 2%) and a short interval follow-up is recommended (1). However, up to one-third of such masses undergo biopsy mainly because of radiologist, referring clinician, or patient concern about the substantial risk of malignancy (2-4). Many BI-RADS 3 masses are traditionally referred for biopsy if they are palpable, large in size, patient is of advanced age or has a positive family history for breast cancer.The BI-RADS 4 assessment is reserved for findings that do not have the classic appearance of malignancy but are sufficiently suspicious to justify a recommendation for biopsy. This category is largely indeterminate and highly variable in outcome. Breast lesions in this category carry 2% to 95% risk for malignancy (1). Thus, almost all recommendations for breast biopsies come from assessments made using this category. According to BI-RADS classification; category 4 is subgrouped as 4A, 4B, and 4C to better inform the clinicians, pathologists, and patients of the degree of concern. However, the criteria for distinguishing among these subcategories have not been well delineated. BI-RADS 4A designates lesions with a low suspicion for malignancy. In this group, a benign pathologic diagnosis is expected and considered concordant (1). Studies of several institutions by the use of their internal criteria revealed positive predictive value (PPV) of 7%-9% for 4A lesions, and more than 50% of the suspicious lesions fall into this category. On the other hand, BI-RADS 4B and 4C 287From the Department of Radiology (S.K.  sibel_ozy@ yahoo.com) Karadeniz Technical University, School of Medicine, Trabzon, Turkey. BREAST IMAGING ORIGINAL ARTICLE PURPOSE We aimed to determine whether low-risk breast masses can be effectively managed with unenhanced magnetic resonance imaging (MRI) combining T2-weighted sequences with diffusion-weighted imaging (DWI) instead of immediate biopsy to decrease negative biopsy rates. METHODSAfter institutional review board and patient approvals, 141 consecutive women with 156 low-risk breast masses, who underwent unenhanced MRI and later on received a final diagnosis, were included in the study. There were 72 BI-RADS 3 masses in women with relative risk factors and 84 BI-RADS 4A masses, all referred for biopsy. Apparent diffusion coefficient (ADC) cutoff was 0.90×10-3 mm2/s. According to ADC values and T2-weighted imaging charact...

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Section: Discussionmentioning

confidence: 98%

Can unenhanced breast MRI be used to decrease negative biopsy rates?

Kul

Oguz²,

Eyüboğlu³

et al. 2015

Diagn Interv Radiol

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“…There have been approaches described for lesion identification in DWI on high b-value images, 22,46 but no data exist for the application of 3D 1 H-MRSI in breast imaging without lesion identification on DCE MR images. Because lesion identification on DCE MR images is the most commonly used approach, we chose to use this in the current study; therefore, DWI and 3D 1 H-MRSI were not assessed individually or in combination.…”

Section: Discussionmentioning

confidence: 99%

Improved Diagnostic Accuracy With Multiparametric Magnetic Resonance Imaging of the Breast Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging, Diffusion-Weighted Imaging, and 3-Dimensional Proton Magnetic Resonance Spectroscopic Imaging

Pinker¹,

Bogner²,

Baltzer³

et al. 2014

Investigative Radiology

110

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“…Response to treatment can be evaluated by studying vascular density or vascular permeability as well as tumor size and water-signal enhancement. The apparent diffusion coefficient (ADC) of tissue water that is associated with changes in tissue and intracellular structure (plasma membrane permeability) can be measured by using DW-MRI 29,37–39…”

Section: Detection Of Breast Cancer By Mri/mrsmentioning

confidence: 99%

Magnetic Resonance in the Detection of Breast Cancers of Different Histological Types

Mayrhofer

Putti

et al. 2013

Magn Reson�Insights

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Breast cancer incidence is increasing worldwide. Early detection is critical for long-term patient survival, as is monitoring responses to chemotherapy for management of the disease. Magnetic resonance imaging and spectroscopy (MRI/MRS) has gained in importance in the last decade for the diagnosis and monitoring of breast cancer therapy. The sensitivity of MRI/MRS for anatomical delineation is very high and the consensus is that MRI is more sensitive in detection than x-ray mammography. Advantages of MRS include delivery of biochemical information about tumor metabolism, which can potentially assist in the staging of cancers and monitoring responses to treatment. The roles of MRS and MRI in screening and monitoring responses to treatment of breast cancer are reviewed here. We rationalize how it is that different histological types of breast cancer are differentially detected and characterized by MR methods.

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Detection of non-palpable breast cancer in asymptomatic women by using unenhanced diffusion-weighted and T2-weighted MR imaging: comparison with mammography and dynamic contrast-enhanced MR imaging

Abstract: DWI+T2WI could be useful in screening breast cancer for patients who cannot receive contrast medium and could be used as a new screening technique for breast cancer.

Cited by 117 publications

References 15 publications

Can unenhanced breast MRI be used to decrease negative biopsy rates?

Can unenhanced breast MRI be used to decrease negative biopsy rates?

Improved Diagnostic Accuracy With Multiparametric Magnetic Resonance Imaging of the Breast Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging, Diffusion-Weighted Imaging, and 3-Dimensional Proton Magnetic Resonance Spectroscopic Imaging

Magnetic Resonance in the Detection of Breast Cancers of Different Histological Types

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