Detection of nerve gases using surface-enhanced Raman scattering substrates with high droplet adhesion

Hakonen, Aron; Rindzevicius, Tomas; Schmidt, Michael; Andersson, Per Ola; Juhlin, Lars; Svedendahl, Mikael; Boisen, Anja; Käll, Mikael

doi:10.1039/c5nr06524k

Cited by 90 publications

(58 citation statements)

References 35 publications

(32 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…During the process of mass transport into the SERS substrate, the surface property of SERS substrate may lead to the spread of the aqueous sample over a bigger area than that of the plasmonic sensing surface (Shao et al, 2015), which makes it difficult to concentrate the analyte molecules for high detection sensitivity. Therefore, much recent attention has been paid toward the surface wettability of SERS substrates (De Angelis et al, 2011; Hakonen et al, 2016; Shao et al, 2015). Fabrizio and co-workers reported SERS substrates with super-hydrophobic artificial surfaces (De Angelis et al, 2011), which could concentrate target samples at the SERS sensing area and enable the detection of Rhodamine 6G (R6G) at atto-molar concentration.…”

Section: Introductionmentioning

confidence: 99%

Detecting explosive molecules from nanoliter solution: A new paradigm of SERS sensing on hydrophilic photonic crystal biosilica

Kong

Duff

et al. 2017

Biosensors and Bioelectronics

View full text Add to dashboard Cite

We demonstrate a photonic crystal biosilica surface-enhanced Raman scattering (SERS) substrate based on a diatom frustule with in-situ synthesized silver nanoparticles (Ag NPs) to detect explosive molecules from nanoliter (nL) solution. By integrating high density Ag NPs inside the nanopores of diatom biosilica, which is not achievable by traditional self-assembly techniques, we obtained ultra-high SERS sensitivity due to dual enhancement mechanisms. First, the hybrid plasmonic-photonic crystal biosilica with three dimensional morphologies was obtained by electroless-deposited Ag seeds at nanometer sized diatom frustule surface, which provides high density hot spots as well as strongly coupled optical resonances with the photonic crystal structure of diatom frustules. Second, we discovered that the evaporation-driven microscopic flow combined with the strong hydrophilic surface of diatom frustules is capable of concentrating the analyte molecules, which offers a simple yet effective mechanism to accelerate the mass transport into the SERS substrate. Using the inkjet printing technology, we are able to deliver multiple 100 pico-liter (pL) volume droplets with pinpoint accuracy into a single diatom frustule with dimension around 30 μm × 7 μm × 5 μm, which allows for label-free detection of explosive molecules such as trinitrotoluene (TNT) down to 10−10 M in concentration and 2.7 × 10−15 g in mass from 120 nL solution. Our research illustrates a new paradigm of SERS sensing to detect trace level of chemical compounds from minimum volume of analyte using nature created photonic crystal biosilica materials.

show abstract

Section: Introductionmentioning

confidence: 99%

Detecting explosive molecules from nanoliter solution: A new paradigm of SERS sensing on hydrophilic photonic crystal biosilica

Kong

Duff

et al. 2017

Biosensors and Bioelectronics

View full text Add to dashboard Cite

show abstract

“…Based on the results above, it is reasonable to set p = 18 mTorr as the optimized RIE chamber pressure for obtaining high‐density Si NPs, as applying it produces NPs of the highest density (∼48 NPs μm −2 ) with a uniform height. It should be pointed out that in previous reports related to the NPs made by a lithography‐free process, only substrates with NPs of low densities less than ∼19 NPs μm −2 were used.…”

Section: Resultsmentioning

confidence: 99%

“…Average EFs of above 10 8 and detection limit down to 10 −10 M have been achieved . Applications such as detecting nerve gases has been realized on such substrates with report high sensitivities . A key advantage of such SERS substrates is their simple fabrication process.…”

Section: Introductionmentioning

confidence: 99%

Optimizing silver‐capped silicon nanopillars to simultaneously realize macroscopic, practical‐level SERS signal reproducibility and high enhancement at low costs

Rindzevicius

Schmidt

et al. 2017

J Raman Spectroscopy

Self Cite

View full text Add to dashboard Cite

The ideal surface‐enhanced Raman spectroscopy (SERS) substrate should fulfil the following: (a) predictable SERS enhancement, (b) macroscale SERS signal uniformity, and (c) suitability for mass production at low costs. Macroscale SERS uniformity and reproducibility at practical levels are big obstacles, which have been preventing most SERS substrates from reliable sensing applications. We have previously shown that SERS‐active nanopillar structures, fabricated by lithography‐free processes, exhibit high average SERS enhancements and are mass producible. Here, we report an optimized process and show that the improved structures exhibit unrivalled macroscale SERS uniformities (RSD: ∼2.5% in millimeter scale, ∼7% in wafer scale) and reproducibility (RSD: ∼1.5% across 3 wafers), while at the same time exhibiting a very large average SERS enhancement factor of >108. The obtained SERS uniformity (~2.5% RSD in millimeter scale) is the best to date measured on large‐area solid SERS substrates. Fast and reproducible SERS analysis of trans‐1,2‐bis (4‐pyridyl) ethylene down to 4 × 10−13 mol is demonstrated using the optimized structures. We emphasize that achieving simultaneously macroscopic, practical‐level SERS signal reproducibility and high enhancement via a lithography‐free process is a notable advance towards industrialization of substrate‐based SERS sensors.

show abstract

“…The advantage of SERS is the significantly reduced cost of Raman instrumentation relative to mass spectrometers. 181–182 …”

Section: Summary and Future Outlookmentioning

confidence: 99%

Bioanalytical applications of surface-enhanced Raman spectroscopy: de novo molecular identification

Nguyen

Peters

Schultz

2017

Reviews in Analytical Chemistry

View full text Add to dashboard Cite

Surface enhanced Raman scattering (SERS) has become a powerful technique for trace analysis of biomolecules. The use of SERS-tags has evolved into clinical diagnostics, the enhancement of the intrinsic signal of biomolecules on SERS active materials shows tremendous promise for the analysis of biomolecules and potential biomedical assays. The detection of the de novo signal from a wide range of biomolecules has been reported to date. In this review, we examine different classes of biomolecules for the signals observed and experimental details that enable their detection. In particular, we survey nucleic acids, amino acids, peptides, proteins, metabolites, and pathogens. The signals observed show that the interaction of the biomolecule with the enhancing nanostructure has a significant influence on the observed spectrum. Additional experiments demonstrate that internal standards can correct for intensity fluctuations and provide quantitative analysis. Experimental methods that control the interaction at the surface are providing for reproducible SERS signals. Results suggest that combining advances in methodology with the development of libraries for SERS spectra may enable the characterization of biomolecules complementary to other existing methods.

show abstract

Detection of nerve gases using surface-enhanced Raman scattering substrates with high droplet adhesion

Cited by 90 publications

References 35 publications

Detecting explosive molecules from nanoliter solution: A new paradigm of SERS sensing on hydrophilic photonic crystal biosilica

Detecting explosive molecules from nanoliter solution: A new paradigm of SERS sensing on hydrophilic photonic crystal biosilica

Optimizing silver‐capped silicon nanopillars to simultaneously realize macroscopic, practical‐level SERS signal reproducibility and high enhancement at low costs

Bioanalytical applications of surface-enhanced Raman spectroscopy: de novo molecular identification

Contact Info

Product

Resources

About