Detection of MUC1 protein on tumor cells and their derived exosomes for breast cancer surveillance with an electrochemiluminescence aptasensor

Li, Rui; An, Yu; Jin, Tongyu; Zhang, Fan; He, Pingang

doi:10.1016/j.jelechem.2021.115011

Cited by 29 publications

(16 citation statements)

References 50 publications

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“…New radiolabeled conjugates and peptides with desirable biological properties have also been used to target tumor-specific MUC1 antigens to diagnose and treat cancers [ 84 ]. Optical and electrochemical platform-based ensemble biosensors and nanosensors for detecting and quantifying MUC1 have also been developed with electrochemiluminescence sensors to detect MUC1 protein exocytosis in breast cancer cells and MUC1 protein in their derived exosomes [ 85 , 86 ].…”

Section: Clinic Applicationmentioning

confidence: 99%

MUC1: Structure, Function, and Clinic Application in Epithelial Cancers

Chen

Zhu

Zhang

et al. 2021

IJMS

117

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The transmembrane glycoprotein mucin 1 (MUC1) is a mucin family member that has different functions in normal and cancer cells. Owing to its structural and biochemical properties, MUC1 can act as a lubricant, moisturizer, and physical barrier in normal cells. However, in cancer cells, MUC1 often undergoes aberrant glycosylation and overexpression. It is involved in cancer invasion, metastasis, angiogenesis, and apoptosis by virtue of its participation in intracellular signaling processes and the regulation of related biomolecules. This review introduces the biological structure and different roles of MUC1 in normal and cancer cells and the regulatory mechanisms governing these roles. It also evaluates current research progress and the clinical applications of MUC1 in cancer therapy based on its characteristics.

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Section: Clinic Applicationmentioning

confidence: 99%

MUC1: Structure, Function, and Clinic Application in Epithelial Cancers

Chen

Zhu

Zhang

et al. 2021

IJMS

117

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show abstract

“…Likewise, CD63 specic aptamer and MUC1 modied Ru(bpy) 3 2+ @SiO 2 nanoparticles (Ru@SiO 2 NPs) were explored to target MCF-7 breast cancer cells for the quantication of MUC1 and derived exosomes. 82 Here, the high surface area of SiO 2 nanoparticles promoted the immobilization of a large amount of Ru(bpy) 3 2+ to amplify ECL intensity for the detection of MCF-7 cancer cell derived exosomes (detection range (3.22 Â 10 À4 -156 mg mL À1 ) with a detection limit of 2.73 Â 10 À4 mg mL À1 ).…”

Section: Review Nanoscale Advancesmentioning

confidence: 99%

Recent advances in biosensing approaches for point-of-care breast cancer diagnostics: challenges and future prospects

et al. 2021

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“…These are capable of binding specific targets with high affinity, specificity, and sensitivity [ 26 , 27 ]. The target molecule can be as simple as a metal ion, and can be as complex as large protein molecules such as cardiac troponin, or even cells [ 28 , 29 , 30 , 31 , 32 ]. Aptamers are designed by an easier, cheaper in vitro method called SELEX (systematic evolution of ligands by exponential enrichment) [ 33 , 34 ].…”

Section: Label and Label-free Aptasensorsmentioning

confidence: 99%

Ultrasensitive Aptasensors for the Detection of Viruses Based on Opto-Electrochemical Readout Systems

et al. 2022

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Viral infections are becoming the foremost driver of morbidity, mortality and economic loss all around the world. Treatment for diseases associated to some deadly viruses are challenging tasks, due to lack of infrastructure, finance and availability of rapid, accurate and easy-to-use detection methods or devices. The emergence of biosensors has proven to be a success in the field of diagnosis to overcome the challenges associated with traditional methods. Furthermore, the incorporation of aptamers as bio-recognition elements in the design of biosensors has paved a way towards rapid, cost-effective, and specific detection devices which are insensitive to changes in the environment. In the last decade, aptamers have emerged to be suitable and efficient biorecognition elements for the detection of different kinds of analytes, such as metal ions, small and macro molecules, and even cells. The signal generation in the detection process depends on different parameters; one such parameter is whether the labelled molecule is incorporated or not for monitoring the sensing process. Based on the labelling, biosensors are classified as label or label-free; both have their significant advantages and disadvantages. Here, we have primarily reviewed the advantages for using aptamers in the transduction system of sensing devices. Furthermore, the labelled and label-free opto-electrochemical aptasensors for the detection of various kinds of viruses have been discussed. Moreover, numerous globally developed aptasensors for the sensing of different types of viruses have been illustrated and explained in tabulated form.

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Detection of MUC1 protein on tumor cells and their derived exosomes for breast cancer surveillance with an electrochemiluminescence aptasensor

Cited by 29 publications

References 50 publications

MUC1: Structure, Function, and Clinic Application in Epithelial Cancers

MUC1: Structure, Function, and Clinic Application in Epithelial Cancers

Recent advances in biosensing approaches for point-of-care breast cancer diagnostics: challenges and future prospects

Ultrasensitive Aptasensors for the Detection of Viruses Based on Opto-Electrochemical Readout Systems

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