Detection of MRSA of Lineages CC130-mecC and CC398-mecA and Staphylococcus delphini-lnu(A) in Magpies and Cinereous Vultures in Spain

Ruiz-Ripa, Laura; Gómez, Paula; Alonso, Carla Andrea; Camacho, Maria Cruz; Puente, Javier de la; Fernández-Fernández, Rosa; Ramiro, Yolanda; Quevedo, Miguel Ángel; Blanco, Juan Manuel; Zarazaga, Myriam; Höfle, Úrsula; Torres, Carmén

doi:10.1007/s00248-019-01328-4

Cited by 35 publications

(51 citation statements)

References 32 publications

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“…The lineage CC130 has already been isolated from a Norway rat [10] and shows a broad host spectrum, especially in wildlife. It has been detected in red foxes, hedgehogs, brown hares, wild boar, rabbits and magpies all over Europe and Tunisia [10,[48][49][50]. In contrast to our study, most of the previously described CC130 isolates were MRSA, harboring the mecC locus.…”

Section: Wild Rats Are Predominantly Colonized With the S Aureus Lincontrasting

confidence: 99%

Molecular Epidemiology of Methicillin-Susceptible and Methicillin-Resistant Staphylococcus aureus in Wild, Captive and Laboratory Rats: Effect of Habitat on the Nasal S. aureus Population

Raafat

Mrochen

Al’Sholui

et al. 2020

Toxins

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Rats are a reservoir of human- and livestock-associated methicillin-resistant Staphylococcus aureus (MRSA). However, the composition of the natural S. aureus population in wild and laboratory rats is largely unknown. Here, 144 nasal S. aureus isolates from free-living wild rats, captive wild rats and laboratory rats were genotyped and profiled for antibiotic resistances and human-specific virulence genes. The nasal S. aureus carriage rate was higher among wild rats (23.4%) than laboratory rats (12.3%). Free-living wild rats were primarily colonized with isolates of clonal complex (CC) 49 and CC130 and maintained these strains even in husbandry. Moreover, upon livestock contact, CC398 isolates were acquired. In contrast, laboratory rats were colonized with many different S. aureus lineages—many of which are commonly found in humans. Five captive wild rats were colonized with CC398-MRSA. Moreover, a single CC30-MRSA and two CC130-MRSA were detected in free-living or captive wild rats. Rat-derived S. aureus isolates rarely harbored the phage-carried immune evasion gene cluster or superantigen genes, suggesting long-term adaptation to their host. Taken together, our study revealed a natural S. aureus population in wild rats, as well as a colonization pressure on wild and laboratory rats by exposure to livestock- and human-associated S. aureus, respectively.

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Section: Wild Rats Are Predominantly Colonized With the S Aureus Lincontrasting

confidence: 99%

Molecular Epidemiology of Methicillin-Susceptible and Methicillin-Resistant Staphylococcus aureus in Wild, Captive and Laboratory Rats: Effect of Habitat on the Nasal S. aureus Population

Raafat

Mrochen

Al’Sholui

et al. 2020

Toxins

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“…Twelve MRSA isolates harbored the mecC gene and were typed as spa-type t843 and t1535 and ascribed to CC130. These mecC-positive isolates were susceptible for all non-β-lactams [53].…”

Section: S Aureus and Mrsa In Wild Animalsmentioning

confidence: 93%

“…The mecA gene was widely distributed among human MRSA isolates and it was not until 2011 that S. aureus isolates harboring the mecC gene was found in humans, livestock, companion and wild animals [50][51][52]. The first assumption was that the mecC was associated with LA-MRSA; however, the detection of mecC-MRSA in wild animals [51,53,54], wastewaters [55] and surface water [56] indicates that the primary reservoirs of mecC gene may be the natural environment.…”

Section: Methicillin-resistant S Aureusmentioning

confidence: 99%

Molecular Epidemiology of Staphylococcus aureus Lineages in Wild Animals in Europe: A Review

et al. 2020

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Staphylococcus aureus is an opportunist pathogen that is responsible for numerous types of infections. S. aureus is known for its ability to easily acquire antibiotic resistance determinants. Methicillin-resistant S. aureus (MRSA) is a leading cause of infections both in humans and animals and is usually associated with a multidrug-resistant profile. MRSA dissemination is increasing due to its capability of establishing new reservoirs and has been found in humans, animals and the environment. Despite the fact that the information on the incidence of MRSA in the environment and, in particular, in wild animals, is scarce, some studies have reported the presence of these strains among wildlife with no direct contact with antibiotics. This shows a possible transmission between species and, consequently, a public health concern. The aim of this review is to better understand the distribution, prevalence and molecular lineages of MRSA in European free-living animals.

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“…Indeed, ST425 is a dominant molecular type that was found in wildlife papers. It does not appear to have a particular host specificity, with isolation reported from mammals including rabbits [35], boar [35,40,53,55,57,58], red deer [35,40,54], and roe deer [40,44] and from vultures [75] (see also Table 1 and Figure 1); these were found exclusively in European countries. The significance of this finding is currently unknown.…”

Section: Discussionmentioning

confidence: 99%

“…ST425 isolates are known to be zoonotic, and have been described as a human colonizer as well, and its ability to cross species barriers may facilitate transmission of resistance genes, including mecC [11]. Other key molecular types present in a wide variety of species included ST398 in Norway rats [30][31][32][33][34], brown hare [40], boar [53,54,56], red deer [53,54], Iberian ibex [54], vulture [75], white stork [76], Eurasian griffon vulture [54], and Canada goose [79] and ST130/CC130, found in a rabbit [35], hedgehog [37,38,40], wood mouse [41], brown rat [40], yellow-necked mouse [42], house mouse [42], brown hare [37,40], mara [48,49], red fox [40], boar [35,55], red deer [35,59], Iberian ibex [53], fallow deer [40], and blue-winged teal [44]. The latter includes a large number of small animals and rodents, suggesting these may be an important reservoir in addition to livestock [91], and ST398 is a known colonizer of humans, particularly those with livestock contact [84].…”

Section: Discussionmentioning

confidence: 99%

Staphylococcus aureus Epidemiology in Wildlife: A Systematic Review

et al. 2020

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Staphylococcus aureus is a common bacterial colonizer of humans and a variety of animal species. Many strains have zoonotic potential, moving between humans and animals, including livestock, pets, and wildlife. We examined publications reporting on S. aureus presence in a variety of wildlife species in order to more cohesively review distribution of strains and antibiotic resistance in wildlife. Fifty-one studies were included in the final qualitative synthesis. The most common types documented included ST398, ST425, ST1, ST133, ST130, and ST15. A mix of methicillin-resistant and methicillin-susceptible strains were noted. A number of molecular types were identified that were likely to be found in wildlife species, including those that are commonly found in humans or other animal species (including livestock). Additional research should include follow-up in geographic areas that are under-sampled in this study, which is dominated by European studies.

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Detection of MRSA of Lineages CC130-mecC and CC398-mecA and Staphylococcus delphini-lnu(A) in Magpies and Cinereous Vultures in Spain

Cited by 35 publications

References 32 publications

Molecular Epidemiology of Methicillin-Susceptible and Methicillin-Resistant Staphylococcus aureus in Wild, Captive and Laboratory Rats: Effect of Habitat on the Nasal S. aureus Population

Molecular Epidemiology of Methicillin-Susceptible and Methicillin-Resistant Staphylococcus aureus in Wild, Captive and Laboratory Rats: Effect of Habitat on the Nasal S. aureus Population

Molecular Epidemiology of Staphylococcus aureus Lineages in Wild Animals in Europe: A Review

Staphylococcus aureus Epidemiology in Wildlife: A Systematic Review

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