Detection of mRNA and Anibody in Mice Injected withPlasmid pCDNA3.1-SRM Carrying African SwineFever Virus Gen Able to Produce Self-Replicating RNA
Gusti Ngurah Bayu Krisna Mahardika,
Made Pharmawati,
Yan Ramona
Abstract:Vaccine technology and gene therapy have been well developed, in which DNA and mRNA is used as a base. This technology has a drawback as high quantities of DNA/RNA are needed, and therefore it is not feasible economically, especially for animals. Self-replicating/amplifying RNA (saRNA) is a promising technology to cope with the drawback of DNA and mRNA vaccines. A pCDNA3.1-SRM plasmid with a gene of picornavirus encoding polymerase enzyme and 5’-and 3’-untranslated region (UTR… Show more
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