Detection of morphine and monoacetylmorphine (MAM) in human hair

Ahrens, Björn; Erdmann, Freidoon; Rochholz, Gertrud; Schütz, H.

doi:10.1007/bf00324655

Cited by 14 publications

(2 citation statements)

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“…As both the alcohol and the hydroxide react with the derivatizing reagent, their use was discarded. Since some authors [17][18][19] proposed the use of acetone with dichloromethane or chloroform as an eluent for some drugs, we assayed different ratios of chloroform/ acetone, containing 30% of BSTFA, with RP-C 18 and XAD-2 as sorbent materials. The signals obtained for the analytes depended strongly on the percentage of acetone present in the mixture.…”

Section: Experimental Variablesmentioning

confidence: 99%

Rapid Solid‐phase Extraction/Derivatization System for Sample Preparation and Gas Chromatographic/Mass Spectrometric Determination of Drugs in Human Urine

Cárdenas

Gallego

Valcárcel

1997

Rapid Commun. Mass Spectrom.

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A novel automatic system has been developed for the rapid solid-extraction and derivatization of different drugs and their metabolites from urine, prior to further analysis. Manual injection of underivatized/derivatized drugs in a GC/MS system, in which the quadrupole mass filter was operated conventionally, provided high sensitivity and selectivity at the selected m/z value. The precision (2.1-6.8%) is acceptable and the overall recovery from urine was determined to be ca. 95%. The effectiveness of this approach is demonstrated with data obtained from different urine samples which had tested positively.

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Section: Experimental Variablesmentioning

confidence: 99%

Rapid Solid‐phase Extraction/Derivatization System for Sample Preparation and Gas Chromatographic/Mass Spectrometric Determination of Drugs in Human Urine

Cárdenas

Gallego

Valcárcel

1997

Rapid Commun. Mass Spectrom.

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show abstract

“…GC/MS has been used to determine total morphine and 6-acetylmorphine in hair (126,127). Morphine and 6-MAM have been detected in hair using a guanidine/mercaptoethanol treatment followed by SPE (128). Capillary GC/MS/MS has been used to detect heroin and its metabolites in hair (129).…”

mentioning

confidence: 99%