Detection of microplastics using inductively coupled plasma-mass spectrometry (ICP-MS) operated in single-event mode

Bolea-Fernández, Eduardo; Rua-Ibarz, Ana; Velimirović, Milica; Tirez, Kristof; Vanhaecke, Frank

doi:10.1039/c9ja00379g

Cited by 105 publications

(61 citation statements)

References 42 publications

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“…[140] Recently, Bolea-Fernandez et al presented a new approach based on ICP-MS detection operated in single-event mode or single particle (SP) ICP-MS mode. [141] This method relies on ultra-fast monitoring of the signal intensity spikes for the massto-charge ratio of C 13+ produced by individual particles. The method was demonstrated with PS microspheres (1-2.5 µm) and allows for quantitative determination of mass concentration and size distribution.…”

Section: Mass Spectrometry Based Techniquesmentioning

confidence: 99%

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A Critical Review on the Impacts of Nanoplastics and Microplastics on Aquatic and Terrestrial Photosynthetic Organisms

Larue

Sarret

Castillo‐Michel

et al. 2021

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121

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Microplastic and nanoplastic contamination is widespread and affects aquatic and terrestrial ecosystems. Photosynthetic organisms are present in both media, they are primary producers, sink for CO2, and they represent a major point of entry in the food chain. Here, the current knowledge on the fate and impacts of microplastics and nanoplastics in interaction with these organisms has been reviewed. As a general trend, plastic characteristics (smaller size and positive charge) play a crucial role in their toxicity towards photosynthetic organisms. Plastic leachates (containing additives) represent also a major source of toxicity, and some harmful compounds such as phthalate esters have been shown to accumulate in plants and generate a risk for the consumers. Adsorption of plastic particles has been evidenced for each type of photosynthetic organism, and uptake and translocation in terrestrial plants was evidenced for nanoplastics, leading to concerns for trophic chain contamination. The available techniques for the detection of microplastics and nanoplastics and their secondary products in biological samples and media are also listed. Finally, the current gaps of knowledge, specific challenges, and future research directions were also discussed.

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Section: Mass Spectrometry Based Techniquesmentioning

confidence: 99%

“…Recently, Bolea-Fernandez et al presented a new approach based on ICP-MS detection operated in single-event mode or single particle (SP) ICP-MS mode 139 . This method relies on ultra-fast monitoring of the signal intensity spikes for the mass-to-charge ratio of C 13+ produced by individual particles.…”

Section: Mass Spectrometry Based Techniquesmentioning

confidence: 99%

A Critical Review on the Impacts of Nanoplastics and Microplastics on Aquatic and Terrestrial Photosynthetic Organisms

Larue

Sarret

Castillo‐Michel

et al. 2021

Small

121

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“…Different types of plastic displayed different fluorescent colours [12]. Other approaches include using micro-and nano-plastics doped with metal/metal-oxide materials [13,14]. These are easily measurable with existent analytical techniques such as inductively coupled plasma-mass spectrometry (ICP-MS) that can characterise small particles at low concentrations.…”

Section: Considering the Hurdles In The Struggle Against Nanoplastic Pollution 21 Rendering Research Quantifiable Through Traceable And Tmentioning

confidence: 99%

Looking at the Bigger Picture—Considering the Hurdles in the Struggle against Nanoplastic Pollution

Briffa

2021

Nanomaterials

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Plastics are considered one of the most serious environmental global concerns as they are ubiquitous and contribute to the build-up of pollution. In August 2020, the BBC reported that scientists found 12–21 million tonnes of tiny plastic fragments floating in the Atlantic Ocean. After release into the environment, plastics from consumer items, such as cosmetics and biomedical products, are subject to degradation and break down into microplastics (<5 mm in diameter) and eventually into nanoplastics (<100 nm in at least one dimension). Given their global abundance and environmental persistence, exposure of humans and animals to these micro- and nano- plastics is unavoidable. “We urgently need to know more about the health impact of microplastics because they are everywhere”, says Dr Maria Neira, Director at the World Health Organization. Nanoplastics are also an emerging environmental concern as little is known about their generation, degradation, transformation, ageing, and transportation. Owing to their small size, nanoplastics can be trapped by filter-feeding organisms and can enter the food chain at an early stage. Therefore, there is a gap in the knowledge that vitally needs to be addressed. This minireview considers how nanoplastic research can be made more quantifiable through traceable and trackable plastic particles and more environmentally realistic by considering the changes over time. It considers how nanoplastic research can use industrially realistic samples and be more impactful by incorporating the ecological impact.

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“…In contrast, only limited applications have been successfully implemented for carbon-based molecules, mostly for laser ablation studies as an internal standard or quality control for acid mineralization, where residual carbon can degrade instrument performance. Recently an application to characterize and quantify micro-plastics in water was developed with ultra-fast detector mode at m/z=13, with calibration with inorganic carbon based only on the 13 C signal [17,18]. The use of 13 C-enriched materials is essential for carbon analysis by ICP-MS because the endogenous contribution of organic bio-molecules makes the analysis of natural abundance carbon too variable and nonspecific to be useful.…”

Section: Carbon Detection By Icp-ms In Biological Samplesmentioning

confidence: 99%

“…However, biomedical applications of ICP-MS have been largely restricted to detection of inorganic metal and nonmetal ions such as K, Zn, and Fe, P, and S in cells and tissues, including micro-samples [12][13][14] and single cells [15,16]. Notably, only a few studies have used ICP-MS to detect C-based materials in the form of micro-plastics [17,18] but to the time of this work we are not aware of applications in biomedical research. This limited application is due largely to the high carbon background in biological samples, as well as the difficulty in sourcing 13 C enriched materials.…”

Section: Introductionmentioning

confidence: 99%

Glucose uptake in mammalian cells measured by ICP-MS

Norman

Ghali

Radzyukevich

et al. 2021

Preprint

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We developed a sensitive, ratiometric method to measure simultaneously 13C-labeled glucose and rubidium in biological samples using ICP-MS. The method uses probe-assisted ultra-sonication with water to extract 13C-[6C]-labeled-D-glucose and other polar analytes from mammalian tissues. It extracts >80% of the reference value for Rb and >95 % of 13C in a CRM spiked with 13C-[6C]-labeled-D-glucose in the micro-molar range. Using optimized instrument conditions, the method achieves a stable 13C/12C signal without spectral interferences. The 13C/12C signal is independent of sample composition and depends linearly on the concentration of 13C-[6C]-labeled-D-glucose in spiked samples. Overall, the method achieves a limit of detection of 10 uM for 6-C-labeled 13C glucose in biological tissues. This detection capability for carbon in biological matrices by ICP-MS opens a wider range of applications for ICP-MS in biomedical research. As proof-of-principle, we combined 13C detection with the multi-channel capability of ICP-MS to measure glucose and rubidium uptake in the same contracting skeletal muscles. Multi-isotope detection is needed to study many biological processes, including coupled membrane transport. These results demonstrate a capability for carbon detection by ICP-MS that can significantly advance studies of complex biological processes that require multi-isotope detection.

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Detection of microplastics using inductively coupled plasma-mass spectrometry (ICP-MS) operated in single-event mode

Abstract: The occurrence of microplastics (MPs) in the environment is a matter of increasing concern. In this work, it has been shown for the first time that ICP-MS operated in single-event mode can be used for the characterization of MPs relying on their C content.

Cited by 105 publications

References 42 publications

A Critical Review on the Impacts of Nanoplastics and Microplastics on Aquatic and Terrestrial Photosynthetic Organisms

A Critical Review on the Impacts of Nanoplastics and Microplastics on Aquatic and Terrestrial Photosynthetic Organisms

Looking at the Bigger Picture—Considering the Hurdles in the Struggle against Nanoplastic Pollution

Glucose uptake in mammalian cells measured by ICP-MS

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