Detection of Methicillin resistance of Staphylococcus aureus among Minia University Hospital Patients

Abstract

The increasing prevalance of methicillin resistant Staphylococcus aureus representes a significant threat to public health mainly due to antibiotics abuse. This study aimed to detection prevalance of resistant isolates of S. aureus to different antimicrobials from plastic surgery department. Methods: In this study, incidence of Staphylococcus aureus infection in Minia University hospital was determined by testing a random sample of 52 patients from wounds samples of plastic surgery department. Then, the disc diffusion method was used to determine the patterns of antimicrobial resistance and efficacy of commercial antibiotics in treatment of Staphylococcus aureus infection. Results: Prevalence of Staphylococcus aureus infection was 42.6% among our patients. Antibiotic resistance rates were alarmingly high, up to 82% in oxacillin, 77% in cefotriaxone, and 54% in amikacin and 50% in cefoxitin. Discussion: This Study showed unprecedented antimicrobial resistance rates of Staphylococcus aureus. New alternative treatment regimens should be considered and investigated to replace the current ineffective therapies.