Detection of malabsorption of low doses of carbohydrate: Accuracy of various breath H2 criteria

Strocchi, Alessandra; Corazza, Gino Roberto; Ellis, Carol; Gasbarrini, Giovanni; Levitt, Michael D.

doi:10.1016/0016-5085(93)90145-3

Cited by 117 publications

(58 citation statements)

References 38 publications

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“…A investigação da má absorção de lactose tornouse mais simples com a utilização do teste respiratório de H 2 no ar expirado. Apesar de ser um método indireto, correlaciona-se bem com os níveis intestinais de lactase e apresenta boa sensibilidade e especificidade (17,27) .…”

Section: Discussionunclassified

Teste do H2 no ar expirado na avaliação de absorção de lactose e sobrecrescimento bacteriano no intestino delgado de escolares

Reis¹,

Morais²,

Fagundes-Neto³

1999

Arq. Gastroenterol.

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Section: Discussionunclassified

Teste do H2 no ar expirado na avaliação de absorção de lactose e sobrecrescimento bacteriano no intestino delgado de escolares

Reis¹,

Morais²,

Fagundes-Neto³

1999

Arq. Gastroenterol.

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“…Breath hydrogen method was used to assess carbohydrate malabsorption (Bond and Levitt, 1977;Strocchi et al, 1993). At 10 min before ingestion of the test meal and at 30 min intervals after ingestion for 5 h, subjects provided a breath sample into a 20 ml syringe.…”

Section: Preparation and Measurement Of Pullulan Fragmentsmentioning

confidence: 99%

“…The number of subjects reaching 10 p.p.m. or higher (a value considered indicative of true malabsorption and colonic fermentation; Bond and Levitt, 1977;Strocchi et al, 1993) for MDX, MCP and LCP, respectively, were 2, 14 and 18 out of 35 subjects.…”

Section: Carbohydrate Malabsorption and Gastrointestinal Symptomsmentioning

confidence: 99%

Effect of carbohydrate digestibility on appetite and its relationship to postprandial blood glucose and insulin levels

et al. 2010

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Background/Objectives: 'Slowly digestible' carbohydrates have been claimed to reduce appetite through their effects on postprandial glucose and insulin levels, but literature is inconsistent. The inconsistencies between studies might be explained by factors other than glycemic effects per se, for example, nutritional or physical properties. We tested this possibility by examining postprandial glucose, insulin and appetite responses to drinks differing only in rate and extent of digestibility of carbohydrates. This was accomplished by comparing different glucose polymers: maltodextrin (rapidly digestible) versus medium-chain pullulan (slowly but completely digestible) versus long-chain pullulan (indigestible). Subjects/Methods: In a randomized double-blind balanced crossover design, 35 subjects received drinks with 15 g test carbohydrate polymers. Key outcome measures were appetite scores, digestibility (in vitro test and breath hydrogen), and (in a subset) glucose and insulin levels. Results: Digestibility, glucose and insulin data confirmed the rapid, slow and nondigestible nature of the test carbohydrates. Despite its low digestibility, only long-chain pullulan reduced appetite compared with the maltodextrin control, whereas the medium-chain pullulan did not. Conclusions: We conclude that glycemic responses per se have minimal effects on appetite, when tested in products differing in only carbohydrate digestibility rate and extent.

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“…Rather than consistently using the time 0 value, the nadir value was selected as the baseline because some subjects have residual hydrogen accumulation in the colon during sleep that may be excreted over the first few hours of the experiment; thus the time 0 value may not reflect a true basal breath hydrogen level (Read et al, 1985;Hertzler et al, 1996). Subjects were classified as having carbohydrate malabsorption (ie positive breath hydrogen test) if their breath hydrogen concentrations increased by more than 10 parts per million (0.9 Â 10 6 g hydrogen/l air or 0.45 mmol/l) from their basal nadir value (Strocchi et al, 1993).…”

Section: Satietymentioning

confidence: 99%

Effects of a beverage containing an enzymatically induced-viscosity dietary fiber, with or without fructose, on the postprandial glycemic response to a high glycemic index food in humans

et al. 2003

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Objective: Dietary supplementation with guar gum or fructose has been reported to reduce the postprandial glycemic response to an oral glucose challenge. As a result of the poor palatability of most foods containing guar gum, a novel low-viscosity beverage with guar gum was developed that becomes viscous in vivo through an enzymatic induction. The primary study objective was to determine the effect of an amylase-induced viscosity (I-V) product, with or without supplemental fructose, on the postprandial glycemic response to a high glycemic index test meal in healthy nondiabetic subjects. Design: The study was a four-treatment, placebo-controlled, double-blind, randomized block protocol. Setting: The study was performed at Glycaemic Index Testing, Inc., Toronto, Ontario, Canada. Subjects: A total of 30 healthy nondiabetic volunteers (13 male, 17 female, mean7s.e.m. age of 5173 y and body mass index of 24.270.4 kg/m 2 ) participated in the study. Intervention: In the morning after an overnight fast, subjects participated in four 3-h meal glucose tolerance tests on separate occasions. The test meals contained 50 g of available carbohydrate from maltodextrin and white bread (control) or the same meal with either 5 g of guar gum (3.6 g galactomannan), 5 g of fructose, or 5 g of guar gum þ 5 g of fructose.Results: Treatments containing guar gum had a reduced (Po0.01) baseline-adjusted peak glucose response and incremental area under the glucose curve. In contrast to previous studies, fructose increased (Po0.05) the baseline-adjusted peak glucose concentration. Conclusions: Guar gum incorporated into an amylase I-V product provided a means to stabilize blood glucose levels by reducing the early phase excursion and then by appropriately maintaining the later phase excursion in healthy nondiabetic humans.

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Detection of malabsorption of low doses of carbohydrate: Accuracy of various breath H2 criteria

Cited by 117 publications

References 38 publications

Teste do H2 no ar expirado na avaliação de absorção de lactose e sobrecrescimento bacteriano no intestino delgado de escolares

Teste do H2 no ar expirado na avaliação de absorção de lactose e sobrecrescimento bacteriano no intestino delgado de escolares

Effect of carbohydrate digestibility on appetite and its relationship to postprandial blood glucose and insulin levels

Effects of a beverage containing an enzymatically induced-viscosity dietary fiber, with or without fructose, on the postprandial glycemic response to a high glycemic index food in humans

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