Detection of lymph node metastases in head and neck cancer: a meta-analysis comparing US, USgFNAC, CT, and MR imaging

Bondt, R.B.J. de; Nelemans, P.J.; Hofman, P.A.M.; Engelshoven, Jos M. A. van; Beets-Tan, R.G.H.

doi:10.1016/j.clinimag.2008.02.004

Cited by 54 publications

(90 citation statements)

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“…In a study conducted by Curtin et al [22], no significant improvement in diagnostic accuracy was achieved with an addition of information on central necrosis to the information on size of lymph node. The reported sensitivity of CT and MR for detecting lymph node metastases ranges from 54 to 95% and from 64 to 92%, respectively, whereas the reported specificity of CT and MR ranges from 39 to 100% and from 40 to 81%, respectively [24].…”

Section: Discussionmentioning

confidence: 99%

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CT, MR, US, 18F-FDG PET/CT, and their combined use for the assessment of cervical lymph node metastases in squamous cell carcinoma of the head and neck

et al. 2008

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The purpose of this retrospective study was to compare the diagnostic value of four different imaging methods-computed tomography (CT), magnetic resonance (MR) imaging, ultrasonography (US), and (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT-and their combined use for preoperative detection of cervical nodal metastases in head and neck squamous cell carcinoma (SCC). Sixty-seven patients (58 men and 9 women; mean age, 60.1 years) with head and neck SCCs underwent CT, MR, US, and PET/CT before surgery. First, each study was reviewed separately for the presence of nodal metastases. Then, the value of combined images was assessed based on a confidence rating score for each modality assigned by observers. These results were verified, on a level-by-level basis, with histopathologic findings. Histopathologic examination revealed nodal metastases in 74 of 402 nodal levels. The sensitivity, specificity, and accuracy were 77.0%, 99.4%, and 95.3% for CT and MR; 78.4%, 98.5%, and 94.8% for US; and 81.1%, 98.2%, and 95.0% for PET/CT, respectively. The comparison of these modalities showed no statistically significant difference among them (p > 0.05). The combination of CT, MR, US, and PET/CT improved sensitivity (86.5%), without loss of specificity (99.4%) and accuracy (97.0%), although the difference failed to reach statistical significance.

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Section: Discussionmentioning

confidence: 99%

“…In addition, US is highly dependent on the experience of the operator. The reported sensitivity of US for detecting lymph node metastases ranges from 63 to 97%, whereas the reported specificity ranges from 74 to 100% [24].…”

Section: Discussionmentioning

confidence: 99%

CT, MR, US, 18F-FDG PET/CT, and their combined use for the assessment of cervical lymph node metastases in squamous cell carcinoma of the head and neck

et al. 2008

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“…Computed tomography and magnetic resonance imaging are still the most common techniques used to detect cervical lymph node metastasis because of their availability in most institutions, low inter-observer variation, and convenience of use [14]. Some studies reported that sensitivities and specificities of CT and MRI showed no significant difference in the detection of cervical lymph node metastases [5,7]. In our study, we chose MRI rather than CT for both primary tumor and neck assessment.…”

Section: Discussionmentioning

confidence: 99%

“…Palpation has been demonstrated to be inaccurate because of at least 30 % occult nodal metastatic rate [4]. Radiological imaging modalities, such as contrast-enhanced computed tomography (CT) and magnetic resonance imaging (MRI), have been widely used for the assessment of cervical nodal metastases, but their accuracy has varied widely in recent reports [5]. [ 18 F] fluorodeoxyglucose positron emission tomography ( 18 F-FDG PET) provides metabolic information in addition to the anatomical image.…”

Section: Introductionmentioning

confidence: 99%

“…Alternative diagnostic modalities are ultrasonography and ultrasonography-guided fine needle aspiration cytology (FNAC). Several studies have reported that the diagnostic accuracy of ultrasonography is at least equal to the other imaging modalities [5,7,9]. However, a reliable and easily applied ultrasonography predictive model for metastatic nodes had not been developed until recently.…”

Section: Introductionmentioning

confidence: 99%

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Efficiency of three-dimensional Doppler ultrasonography in assessing nodal metastasis of head and neck cancer

Hong

Lai

Lee

et al. 2014

Eur Arch Otorhinolaryngol

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The aim of this study was to assess the clinical usefulness of three-dimensional (3D) color Doppler ultrasonography with a novel predictive model in the detection of cervical metastasis of untreated head and neck squamous cell carcinoma patients. We assessed cervical lymph node metastasis in 52 head and neck squamous cell carcinoma patients by 3D color Doppler ultrasonography, magnetic resonance imaging, and [(18)F] fluorodeoxyglucose positron emission tomography with computed tomography. Pathologic analysis was used as the gold standard for evaluation of these imaging modalities. The rate of correct N staging was 84.6% on ultrasonography, 55.8% on magnetic resonance imaging, and 71.2% on positron emission tomography/computed tomography. On a level-by-level basis, the ultrasonography had 78.9% sensitivity, 99.0% specificity, 93.8% positive predictive value, 96.0% negative predictive value, and 95.7% accuracy. It also showed the highest agreement to histology results as compared with magnetic resonance imaging and positron emission tomography/computed tomography (kappa value = 0.832, 0.506, and 0.537, respectively). 3D Doppler ultrasonography with our prediction model provides a rapid, low-cost, noninvasive, and reliable method with low inter-observation variations for detecting neck metastasis of head and neck squamous cell carcinoma patients.

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Para-aortic lymph node sampling in pancreatic head adenocarcinoma

Schwarz

Lupinacci

Svrcek

et al. 2014

British Journal of Surgery

105

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Detection of lymph node metastases in head and neck cancer: a meta-analysis comparing US, USgFNAC, CT, and MR imaging

Cited by 54 publications

References 0 publications

CT, MR, US, 18F-FDG PET/CT, and their combined use for the assessment of cervical lymph node metastases in squamous cell carcinoma of the head and neck

CT, MR, US, 18F-FDG PET/CT, and their combined use for the assessment of cervical lymph node metastases in squamous cell carcinoma of the head and neck

Efficiency of three-dimensional Doppler ultrasonography in assessing nodal metastasis of head and neck cancer

Para-aortic lymph node sampling in pancreatic head adenocarcinoma

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