Detection of low bone mineral density by dual energy x ray absorptiometry in unsuspected suboptimally treated coeliac disease.

Walters, J. R. F.; Banks, L. M.; Butcher, G. P.; Fowler, Cosmo

doi:10.1136/gut.37.2.220

Cited by 82 publications

(44 citation statements)

References 18 publications

(7 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Whilst osteomalacia may be the first presentation of celiac disease, many patients with otherwise asymptomatic celiac disease are found to have significantly diminished bone density [32,33]. Numerous factors have been postulated to effect BMD in celiac disease.…”

Section: Discussionmentioning

confidence: 99%

Long-term Fracture Risk in Patients with Celiac Disease: A Population-Based Study in Olmsted County, Minnesota

et al. 2007

View full text Add to dashboard Cite

Celiac disease is associated with decreased bone density, but there are conflicting data regarding fracture risk. We determined the fracture incidence relative to matched controls in a population-based cohort with celiac disease before and after diagnosis. Olmsted County residents with celiac disease (n = 83) diagnosed between 1950 and 2002 were compared with 166 gender and age matched controls. Fracture histories were ascertained from each subject's medical records. Celiac disease is linked to an increased fracture risk before and after diagnosis. Before the index date, cases had a fracture rate twice that of controls (CI: 1.0-3.9, P = 0.045) and 2.5-fold greater after the index date (CI: 1.1-5.6, P = 0.026). Appendicular and axial fractures were 2.5 (CI: 0.9-6.5) and 3.2 times more likely (CI: 1.0-10.5) after the index date. These observations support a rationale for earlier detection of celiac disease, and active management of bone disease before bone effects have occurred, to reduce the persistent risk of fractures.

show abstract

Section: Discussionmentioning

confidence: 99%

Long-term Fracture Risk in Patients with Celiac Disease: A Population-Based Study in Olmsted County, Minnesota

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Achieving normal bone mass was dependent on early diagnosis of the disease. 1,[3][4][5]12,13,[21][22][23][24] There is currently a discussion in the literature about the duration of gluten-free diet that is needed to reverse the changes in bone metabolism relating to celiac disease. Recovery from bone abnormalities has been found to be correlated with the duration of the gluten-free diet.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of low bone mineral density in children and adolescents with celiac disease under treatment

2009

View full text Add to dashboard Cite

CONTEXT AND OBJECTIVE: Low bone mineral density may be a finding among children and adolescents with celiac disease, including those undergoing treatment with a gluten-free diet, but the data are contradictory. The aim of this study was to determine the frequency of bone mineral density abnormalities in patients on a gluten-free diet, considering age at diagnosis and duration of dietary treatment. DESIGN AND SETTING:Cross-sectional prevalence study at the Pediatric Gastroenterology Outpatient Clinic of Instituto Materno Infantil Professor Fernando Figueira.METHODS: Thirty-one patients over five years of age with celiac disease and on a gluten-free diet were enrolled. Bone mineral density (in g/cm 2 ) was measured in the lumbar spine and whole body using bone densitometry and categorized using the criteria of the International Society for Clinical Densitometry, i.e. low bone mineral density for chronological age ≤ -2.0 Z-scores. Age at diagnosis and duration of dietary treatment were confirmed according to the date of starting the gluten-free diet.RESULTS: Low bone density for chronological age was present in 3/31 patients in the lumbar spine and 1/31 in the whole body (also with lumbar spine abnormality). At diagnosis, three patients with low bone mineral density for the chronological age were more than 7.6 years old. These patients had been on a gluten-free diet for six and seven months and 3.4 years. CONCLUSION:Pediatric patients with celiac disease on long-term treatment are at risk of low bone mineral density. Early diagnosis and long periods of gluten-free diet are directly implicated in bone density normalization.RESUMO CONTEXTO E OBJETIVO: Baixa densidade mineral óssea pode ser encontrada em crianças e adolescentes com doença celíaca, incluindo aqueles em tratamento com dieta sem glúten, mas dados são contraditórios. O objetivo deste estudo foi determinar a frequência de alteração da densidade mineral óssea nos pacientes em dieta sem glúten, conforme a idade ao diagnóstico e o tempo de tratamento dietético. TIPO DE ESTUDO E LOCAL: Foi realizado estudo transversal de prevalência no Ambulatório de Gastroenterologia Pediátrica do Instituto Materno Infantil Professor Fernando Figueira (IMIP).MÉTODOS: Trinta e um pacientes maiores de cinco anos com doença celíaca que estavam em dieta sem gluten foram avaliados. A densidade mineral óssea (em g/cm 2 ) foi medida na coluna lombar e no corpo inteiro utilizando densitometria óssea, categorizando-a pelo critério da Sociedade Internacional para Densitometria Clínica (baixa densidade mineral óssea para a idade cronológica ≤ -2.0 escores Z). A idade ao diagnóstico e o tempo de tratamento foram confirmados pela data de início da dieta sem glúten.RESULTADOS: Baixa densidade mineral óssea para a idade cronológica foi detectada em 3/31 pacientes na coluna lombar e 1/31 no corpo inteiro (também apresentava alteração da coluna lombar). Ao diagnóstico, três pacientes com baixa densidade mineral óssea para a idade cronológica estavam com mais de 7,6 anos. Esses pacient...

show abstract

“…A doença celíaca (DC) apresenta alta incidência de fraturas ósseas no esqueleto periférico 2,3 . Os adultos com DC apresentam risco aumentado para DMO reduzida [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] . Por outro lado, são poucos os dados acerca da DMO em crianças e adolescentes com DC [21][22][23][24][25][26][27][28][29] .…”

unclassified

Celiac disease under treatment: evaluation of bone mineral density

Carvalho¹,

Sdepanian²,

Neto³

et al. 2003

J Pediatr (Rio J)

View full text Add to dashboard Cite

Objective: the present study was designed to compare the bone mineral density of children and adolescents with celiac disease to the bone mineral density of controls, and to evaluate laboratory analysis of calcium metabolism of celiac disease patients.Methods: thirty celiac disease patients (17 children, 13 adolescents), on a gluten-free diet, and 23 healthy subjects were studied. Tests of bone mineral density of the lumbar spine (DEXA, Lunar) were performed in all patients and controls. Laboratory analysis of calcium metabolism was performed in all patients.Results: mean weight and height of adolescents with celiac disease were lower than mean weight and height of controls (p<0.05). Bone mineral density in adolescents with celiac disease was significantly reduced if compared to controls (p=0.015), whereas no significant difference was found among children with celiac disease and controls. The number of adolescents who had started a glutenfree diet after the age of 2 years was higher than in children (p=0.003). Serum levels of ionized calcium, total calcium and parathormone were normal.Conclusions: the one mineral density of adolescents with celiac disease was lower than controls; whereas, no difference was found between the bone mineral density of children with celiac disease and controls.J Pediatr (Rio J) 2003;79(4):303-8: celiac disease, diet therapy, bone density, child, adolescent. ResumoObjetivo: comparar a densidade mineral óssea de crianças e adolescentes com doença celíaca em tratamento com controles sadios, e avaliar exames laboratoriais relacionados com o metabolismo do cálcio.Métodos: foram estudados 30 pacientes com doença celíaca em dieta isenta de glúten, 17 crianças e 13 adolescentes, e 23 indivíduos saudáveis. Todos os pacientes e controles realizaram a densidade mineral óssea (DEXA, Lunar). Os pacientes realizaram dosagem sérica de cálcio total, cálcio ionizado, fósforo, magnésio, fosfatase alcalina e paratormônio.Resultados: a média de peso, estatura e densidade mineral óssea dos adolescentes com doença celíaca foi menor do que dos controles (p<0,05), enquanto que não se observaram diferenças estatisticamente significantes destes parâmetros, comparando as crianças com doença celíaca com os controles. A proporção de adolescentes que iniciou dieta isenta de glúten após os dois anos de idade foi maior do que a de crianças (p<0,05). Os pacientes apresentaram níveis séricos normais de cálcio ionizado, cálcio total e paratormônio.Conclusões: a densidade mineral óssea dos adolescentes com doença celíaca em dieta isenta de glúten foi menor do que dos controles. Por outro lado, não houve diferença entre a densidade mineral óssea de crianças com doença celíaca e controles.J Pediatr (Rio J) 2003;79(4):303-8: doença celíaca, dietoterapia, densidade óssea, criança, adolescente.

show abstract

Detection of low bone mineral density by dual energy x ray absorptiometry in unsuspected suboptimally treated coeliac disease.

Abstract: Patients with coeliac disease may present with calcium malabsorption but it is unclear whether this results in longterm impairment of bone mineralisation. Dual

Cited by 82 publications

References 18 publications

Long-term Fracture Risk in Patients with Celiac Disease: A Population-Based Study in Olmsted County, Minnesota

Long-term Fracture Risk in Patients with Celiac Disease: A Population-Based Study in Olmsted County, Minnesota

Prevalence of low bone mineral density in children and adolescents with celiac disease under treatment

Celiac disease under treatment: evaluation of bone mineral density

Contact Info

Product

Resources

About