Detection of low- and high-frequency rhythms in the  variability of skin sympathetic nerve activity

Cogliati, Chiara; Magatelli, Renata; Montano, Nicola; Somers, Virend K.

doi:10.1152/ajpheart.2000.278.4.h1256

Cited by 32 publications

(26 citation statements)

References 25 publications

(38 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In all thermal conditions, data were subdivided into 1,024-point segments (128 s) with 50% overlap, windowed (Hanning method), transformed, and averaged. For consistency with previous studies (2,5), the LF (0.03-to 0.15-Hz) and HF (0.15-to 0.45-Hz) spectral powers of SSNA were calculated from the autospectra. Because the present results showed that spectral power of integrated SSNA can be Ͼ0.45 Hz but Ͻ2.5 Hz, we calculated the spectral power between 0.45 and 2.5 Hz and termed this the veryhigh-frequency (VHF) component.…”

Section: Discussionmentioning

confidence: 92%

“…Respiratory rhythms in integrated SSNA (1) and in single vasoconstrictor and sudomotor neurons (13) were verified using interval histogram analytic techniques. Using spectral analysis of integrated SSNA, Cogliati et al (2) showed that SSNA during normothermia had a high-frequency (HF) oscillatory component, which reflected the respiratory rhythm. Moreover, they reported that SSNA also had a low-frequency (LF, 0.1-Hz) oscillatory component, which was coherent with LF components of R-R interval and blood pressure (2).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Spectral characteristics of skin sympathetic nerve activity in heat-stressed humans

Cui¹,

Sathishkumar²,

Wilson³

et al. 2006

American Journal of Physiology-Heart and Circulatory Physiology

View full text Add to dashboard Cite

Skin sympathetic nerve activity (SSNA) exhibits low- and high-frequency spectral components in normothermic subjects. However, spectral characteristics of SSNA in heat-stressed subjects are unknown. Because the main components of the integrated SSNA during heat stress (sudomotor/vasodilator activities) are different from those during normothermia and cooling (vasoconstrictor activity), we hypothesize that spectral characteristics of SSNA in heat-stressed subjects will be different from those in subjects subjected to normothermia or cooling. In 17 healthy subjects, SSNA, electrocardiogram, arterial blood pressure (via Finapres), respiratory activity, and skin blood flow were recorded during normothermia and heat stress. In 7 of the 17 subjects, these variables were also recorded during cooling. Spectral characteristics of integrated SSNA, R-R interval, beat-by-beat mean blood pressure, skin blood flow variability, and respiratory excursions were assessed. Heat stress and cooling significantly increased total SSNA. SSNA spectral power in the low-frequency (0.03-0.15 Hz), high-frequency (0.15-0.45 Hz), and very-high-frequency (0.45-2.5 Hz) regions was significantly elevated by heat stress and cooling. Interestingly, heat stress caused a greater relative increase of SSNA spectral power within the 0.45- to 2.5-Hz region than in the other spectral ranges; cooling did not show this effect. Differences in the SSNA spectral distribution between normothermia/cooling and heat stress may reflect different characteristics of central modulation of vasoconstrictor and sudomotor/vasodilator activities.

show abstract

Section: Discussionmentioning

confidence: 92%

mentioning

confidence: 99%

Spectral characteristics of skin sympathetic nerve activity in heat-stressed humans

Cui¹,

Sathishkumar²,

Wilson³

et al. 2006

American Journal of Physiology-Heart and Circulatory Physiology

View full text Add to dashboard Cite

show abstract

“…Studies that investigated the relationship between more direct measures of sympathetic nerve firing and HRV produced conflicting results. Although some reports found no significant correlation between changes in cardiac or muscle sympathetic nerve activity (MSNA) and changes in LF R-R interval power (20,26), others reported that spectral analysis of MSNA and R-R interval variability share almost identical oscillatory components with a high correlation between both measures in the human subject (9,36,38,50). LF R-R interval oscillations may also be related to cardiac sympathetic modulation resulting from the baroreflex response to LF BP oscillations (8).…”

Section: Interpretation Of Changes In Hrvmentioning

confidence: 99%

Heart rate variability and spontaneous baroreflex sequences in supine healthy volunteers subjected to nasal positive airway pressure

Valipour¹,

Schneider²,

Kössler³

et al. 2005

Journal of Applied Physiology

View full text Add to dashboard Cite

. Heart rate variability and spontaneous baroreflex sequences in supine healthy volunteers subjected to nasal positive airway pressure. J Appl Physiol 99: [2137][2138][2139][2140][2141][2142][2143] 2005. First published July 7, 2005; doi:10.1152/japplphysiol.00003.2005.-To determine the dynamic effects of short-term nasal positive airway pressure (nPAP) on cardiovascular autonomic control, continuous recordings of noninvasively obtained hemodynamic measurements and heart rate variability (HRV) were obtained in 10 healthy subjects during frequency-controlled breathing (between 0.20 and 0.24 Hz) in supine posture under different pressures of nPAP ranging from 3 to 20 cmH 2O. HRV was assessed using spectral analysis of the R-R interval. The slope of the regression line between spontaneous systolic blood pressure and pulse interval changes was taken as an index of the sensitivity of arterial baroreflex modulation of heart rate (sequence method). Application of nPAP resulted in a pressure-dependent decrease of cardiac output and stroke volume (P Ͻ 0.05, ANOVA) and in an increase in total peripheral resistance (P Ͻ 0.03, ANOVA). Hemodynamic changes under increasing nPAP were accompanied by a decrease in total power of HRV despite mean R-R interval remaining unchanged. The overall decrease in HRV was accompanied by a reduction across all frequency bands when absolute units were used (P Ͻ 0.01). When the power of low frequency and high frequency was calculated in normalized units, a diminished high frequency and an increased low-to-high frequency ratio were observed (P Ͻ 0.05). Compared with low levels of nPAP, pressure levels of Ͼ10 cmH 2O were associated with a significant decline in the mean slope of spontaneous baroreceptor sequences (P Ͻ 0.04). These findings indicate that short-term administration of nPAP in normal subjects exerts significant alterations in R-R interval variability and spontaneous baroreflex modulation of heart rate. cardiac output; cardiovascular autonomic control; heart-lung interaction RESPIRATION SIGNIFICANTLY INFLUENCES autonomic cardiovascular control (12). During normal breathing, oscillatory changes of left ventricular stroke volume (SV) and arterial blood pressure (BP) are sensed by baroreceptors, which provoke parallel R-R interval changes by means of baroreflex physiology (27). Hemodynamic oscillations during normal (negative pressure) respiration are predominantly due to changes in intrathoracic pressure (ITP) (30). However, little is known about the effects of augmented positive ITP, which occurs with positive airway pressure (PAP) ventilation, on cardiovascular autonomic control. The application of PAP, both invasively or noninvasively, increases ITP and may result in a reduction in cardiac filling pressures (23,29,37,43). A reduction in cardiac filling pressures associated with PAP (or positive end-expiratory pressure) may induce a compensatory increase in vascular resistance to maintain systemic arterial pressure in the face of a reduced cardiac output (CO) (5, 41). The increase in...

show abstract

“…Resolution of these questions will require invasive arteriovenous studies of different adipose tissue depots and further studies of in vitro oscillations with and without stimulation by sympathetic agonists. Cyclicity is a characteristic shared by a variety of systems that are under control of the sympathetic nervous system, such as oscillations of skin sympathetic nerve activity (47) and sympathetic nerve discharge by central neurons (48). The activity of the sympathetic nervous system is directly influenced by the CNS (13), which plays an important role as the control center of energy homeostasis (9,49).…”

mentioning

confidence: 99%

Burst-like control of lipolysis by the sympathetic nervous system in vivo

Hücking¹,

Hamilton-Wessler²,

Ellmerer³

et al. 2003

J. Clin. Invest.

View full text Add to dashboard Cite

Rapid oscillations of visceral lipolysis have been reported. To examine the putative role of the CNS in oscillatory lipolysis, we tested the effects of β 3 -blockade on pulsatile release of FFAs. Arterial blood samples were drawn at 1-minute intervals for 120 minutes from fasted, conscious dogs (n = 7) during the infusion of saline or bupranolol (1.5 µg/kg/min), a high-affinity β 3 -blocker. FFA and glycerol time series were analyzed and deconvolution analysis was applied to estimate the rate of FFA release. During saline infusion FFAs and glycerol oscillated in phase at about eight pulses/hour. Deconvolution analysis showed bursts of lipolysis (nine pulses/hour) with time-dependent variation in burst frequency. Bupranolol completely removed rapid FFA and glycerol oscillations. Despite removal of lipolytic bursts, plasma FFAs (0.31 mM) and glycerol (0.06 mM) were not totally suppressed and deconvolution analysis revealed persistent non-oscillatory lipolysis (0.064 mM/min). These results show that lipolysis in the fasting state consists of an oscillatory component, which appears to be entirely dependent upon sympathetic innervation of the adipose tissue, and a non-oscillatory, constitutive component, which persists despite β 3 -blockade. The extinction of lipid fuel bursts by β 3 -blockade implies a role for the CNS in the maintenance of cyclic provision of lipid fuels.

show abstract

Detection of low- and high-frequency rhythms in the variability of skin sympathetic nerve activity

Cited by 32 publications

References 25 publications

Spectral characteristics of skin sympathetic nerve activity in heat-stressed humans

Spectral characteristics of skin sympathetic nerve activity in heat-stressed humans

Heart rate variability and spontaneous baroreflex sequences in supine healthy volunteers subjected to nasal positive airway pressure

Burst-like control of lipolysis by the sympathetic nervous system in vivo

Contact Info

Product

Resources

About