Detection of Looping During Colonoscopy Using Bending Sensors

Choi, JungHun

doi:10.2174/1875181401305010001

Cited by 3 publications

(1 citation statement)

References 36 publications

(37 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While the minimum bending radius (MBR) of conventional imaging fiber bundles with 1 mm outer diameter (Fujikura LTd., Tokyo, Japan) is 100 mm, a leached fiber bundle with the same diameter can reduce the MBR down to 25 mm. Leached fiber bundles are suitable for compatibility with clinical endoscopes because the MBR of the imaging scope is not larger than 50.8 mm [10]. To insert into the biopsy channel of commercial clinical endoscopes, we constructed our probe using a leached fiber bundle [11].…”

Section: Introductionmentioning

confidence: 99%

Clinically compatible flexible wide-field multi-color fluorescence endoscopy with a porcine colon model

Park

Yoo

et al. 2017

Biomed. Opt. Express

View full text Add to dashboard Cite

Early detection of structural or molecular changes in dysplastic epithelial tissues is crucial for cancer screening and surveillance. Multi-targeting molecular endoscopic fluorescence imaging may improve noninvasive detection of precancerous lesions in the colon. Here, we report the first clinically compatible, wide-field-of-view, multi-color fluorescence endoscopy with a leached fiber bundle scope using a porcine model. A porcine colon model that resembles the human colon is used for the detection of surrogate tumors composed of multiple biocompatible fluorophores (FITC, ICG, and heavy metal-free quantum dots (hfQDs)). With an ex vivo porcine colon tumor model, molecular imaging with hfQDs conjugated with MMP14 antibody was achieved by spraying molecular probes on a mucosa layer that contains xenograft tumors. With an in vivo porcine colon embedded with surrogate tumors, target-to-background ratios of 3.36 ± 0.43, 2.70 ± 0.72, and 2.10 ± 0.13 were achieved for FITC, ICG, and hfQD probes, respectively. This promising endoscopic technology with molecular contrast shows the capacity to reveal hidden tumors and guide treatment strategy decisions. Sharma, "Comparison of the yield and miss rate of narrow band imaging and white light endoscopy in patients undergoing screening or surveillance colonoscopy: a meta-analysis," Am. J. Gastroenterol. 107(3), 363-371 (2012). 2. Sturm, M.B. and T.D. Wang," Emerging optical methods for surveillance of Barrett's oesophagus, " Gut, gutjnl-2013" Gut, gutjnl- -306706 (2015. Rat, P. Roignot, J. Faivre, P. Laurent-Puig, and F. Piard, "Mutations in the RAS-MAPK, PI (3) K (phosphatidylinositol-3-OH kinase) signaling network correlate with poor survival in a population-based series of colon cancers," Int.

show abstract

Section: Introductionmentioning

confidence: 99%

Clinically compatible flexible wide-field multi-color fluorescence endoscopy with a porcine colon model

Park

Yoo

et al. 2017

Biomed. Opt. Express

View full text Add to dashboard Cite

show abstract

Preclinical evaluation of porcine colon resection using hollow core negative curvature fibre delivered ultrafast laser pulses

Mohanan

Beck

West

et al. 2019

Journal of Biophotonics

View full text Add to dashboard Cite

Ultrashort pulse lasers offer great promise for tissue resection with exceptional precision and minimal thermal damage. Surgery in the bowel requires high precision and minimal necrotic tissue to avoid severe complications such as perforation. The deployment of ultrashort lasers in minimally invasive or endoscopic procedures has been hindered by the lack of suitable optical fibres for high peak powers. However, recent developments of hollow core microstructured fibres provide potential for delivery of such pulses throughout the body. In this study, analysis of laser ablation via a scanning galvanometer on a porcine colon tissue model is presented. A thermally damaged region (<85 μm) and fine depth control of ablation using the pulse energies 46 and 33 μJ are demonstrated. It is further demonstrated that such pulses suitable for precision porcine colon resection can be flexibly delivered via a hollow core negative curvature fibre (HC-NCF) and again ablation depth can be controlled with a thermally damaged region <85 μm. Ablation volumes are comparable to that of early stage lesions in the inner lining of the colon. This study concludes that the combination of ultrashort pulses and flexible fibre delivery via HC-NCF present a viable route to new minimally invasive surgical procedures. K E Y W O R D S negative curvature fibre, plasma-mediated ablation, porcine colon, thermal necrosis, ultrafast laser surgery

show abstract

Safety, Feasibility, and Efficacy of Pancolonic Retroflexed Viewing Using a Short-turn Radius Colonoscope

Robles-Medranda

Soria-Alcívar²,

Oleas³

et al. 2019

Journal of Clinical Gastroenterology

View full text Add to dashboard Cite

Goals: The goal of this study was to evaluate the safety and feasibility of routine segmental retroflexed withdrawal viewing (RV) of the colon with the RetroView colonoscope. Materials and Methods: This was a prospective, single-center, 2-stage diagnostic trial. After cecal intubation, mucosal evaluation by forward viewing (FV) and RV was performed by segment (right, transverse, left, and sigmoid colon, and rectum). Lesions detected during FV were removed and/or marked before retroflexion. Safety and feasibility were measured through adverse event and technical success rates. All lesions detected and removed endoscopically were recorded. Results: Two hundred twenty-five patients underwent colonoscopy with the RetroView colonoscope. Retroflexion by segment was successful in the right, transverse, left, and sigmoid colon, and rectum in 98.9%, 100%, 100%, 82.6%, and 100% of cases, respectively. The mean total procedure time was 16.6 minutes. Ninety-four lesions were detected through retroflexion evaluation, for an increase in the lesions’ detection rate of 30.7%. The per-adenoma miss rate of standard colonoscopy (FV) was 35.71%. The adenoma detection rate (ADR) for FV was 16%, whereas, when performing FV and RV, the ADR increased to 24.9%. Adverse events were recorded in 0.4% of cases. Therapeutic procedures were performed successfully through the retroflexed position in 81/225 patients. Conclusions: Routine retroflexion evaluation of the colonic mucosa by segment using the RetroView colonoscope is safe and feasible. Retroflexion evaluation increases the detection rate of colonic lesions behind folds, including the number of adenomas per colonoscopy and ADR, offering a complete screening colonoscopy. All therapeutic procedures are feasible through retroflexion.

show abstract

Detection of Looping During Colonoscopy Using Bending Sensors

Cited by 3 publications

References 36 publications

Clinically compatible flexible wide-field multi-color fluorescence endoscopy with a porcine colon model

Clinically compatible flexible wide-field multi-color fluorescence endoscopy with a porcine colon model

Preclinical evaluation of porcine colon resection using hollow core negative curvature fibre delivered ultrafast laser pulses

Safety, Feasibility, and Efficacy of Pancolonic Retroflexed Viewing Using a Short-turn Radius Colonoscope

Contact Info

Product

Resources

About