Detection of live SARS-CoV-2 virus and its variants by specially designed SERS-active substrates and spectroscopic analyses

Advances in uremic toxin detection and monitoring in the management of chronic kidney disease progression to end-stage renal disease

“…After applying a Raman laser of an appropriate wavelength, a strong SERS effect occurs, creating many small hotspots within each bowl, characteristic Raman signals corresponding to the functional groups of the target molecule can be identified. 87–89 However, when interfering substances are present in clinical samples, SERS signal of the target molecule (such as several characteristic peaks) will be partially weakened, affecting detection sensitivity. 90,91 Through integration with POC testing, a portable label-free SERS system for on-site testing can monitor uremic toxins.…”

“…This mechanism of utilizing hotspot effects, distance, and characteristic SERS peaks to detect middle molecules provides an independent indication of molecular capture, improves sensitivity, and enables precise identification, bringing hope for innovative detection methods. 89,99…”