Detection of latent tuberculosis infection in hemodialysis patients: Comparison between the quantiferon-tuberculosis gold test and the tuberculin skin test

Hussein, Mona T.; Yousef, Laila M; Ali, Ali T.

doi:10.4103/ejb.ejb_19_17

Cited by 2 publications

(4 citation statements)

References 31 publications

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“…In comparison with other MENA countries (Table 3), Lebanon has the lowest LTBI prevalence among HD patients according to IGRA tests. Higher percentages of LTBI have been reported in Iran [32], Egypt [33], and Saudi Arabia [34], in which 23.4%, 35.1%, and 45.3% of HD patients were shown to have LTBI, respectively. Notably, the highest percentages of LTBI among HD patients were observed in Turkey, ranging from 39.6% to 61% [19,[35][36][37][38][39][40].…”

Section: Discussionmentioning

confidence: 88%

“…In immunocompromised patients, such as those undergoing HD treatment, the TST performs poorly due to an increased possibility of falsenegative results [53]. In addition, Hussein et al [33] demonstrated that the prevalence of LTBI changed significantly according to the adopted diagnostic method, with 13.5% using the TST and 35.1% using QFT-GIT. The results of most studies in Saudi Arabia [34,47,48], Egypt [33,42], and Turkey [19,36,[38][39][40] corroborated that using IGRA tools allows the better detection of LTBI among HD patients.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, Hussein et al [33] demonstrated that the prevalence of LTBI changed significantly according to the adopted diagnostic method, with 13.5% using the TST and 35.1% using QFT-GIT. The results of most studies in Saudi Arabia [34,47,48], Egypt [33,42], and Turkey [19,36,[38][39][40] corroborated that using IGRA tools allows the better detection of LTBI among HD patients. On the other hand, only three studies conducted in Egypt, Iran, and Turkey [32,37,43] showed discordant data, with a higher LTBI prevalence using the TST compared to IGRA tests.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of Latent Tuberculosis Infection among Patients Undergoing Regular Hemodialysis in Disenfranchised Communities: A Multicenter Study during COVID-19 Pandemic

et al. 2023

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Background and Objectives: Due to their weakened immune response, hemodialysis (HD) patients with latent tuberculosis infection (LTBI) are at higher risk for active tuberculosis (TB) disease and are more subject to patient-to-patient transmission within dialysis units. Consequently, current guidelines advocate screening these patients for LTBI. To our knowledge, the epidemiology of LTBI in HD patients has never been examined before in Lebanon. In this context, this study aimed to determine LTBI prevalence among patients undergoing regular HD in Northern Lebanon and to identify potential factors associated with this infection. Notably, the study was conducted during the COVID-19 pandemic, which is likely to have catastrophic effects on TB and increase the risk of mortality and hospitalization in HD patients. Materials and Methods: A multicenter cross-sectional study was carried out in three hospital dialysis units in Tripoli, North Lebanon. Blood samples and sociodemographic and clinical data were collected from 93 HD patients. To screen for LTBI, all patient samples underwent the fourth-generation QuantiFERON-TB Gold Plus assay (QFT-Plus). Multivariable logistic regression analysis was used to identify the predictors of LTBI status in HD patients. Results: Overall, 51 men and 42 women were enrolled. The mean age of the study population was 58.3 ± 12.4 years. Nine HD patients had indeterminate QFT-Plus results and were therefore excluded from subsequent statistical analysis. Among the remaining 84 participants with valid results, QFT-Plus was positive in 16 patients, showing a positivity prevalence of 19% (95% interval for p: 11.3%, 29.1%). Multivariable logistic regression analysis showed that LTBI was significantly associated with age [OR = 1.06; 95% CI = 1.01 to 1.13; p = 0.03] and a low-income level [OR = 9.29; 95% CI = 1.62 to 178; p = 0.04]. Conclusion: LTBI was found to be prevalent in one in five HD patients examined in our study. Therefore, effective TB control measures need to be implemented in this vulnerable population, with special attention to elderly patients with low socioeconomic status.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Prevalence of Latent Tuberculosis Infection among Patients Undergoing Regular Hemodialysis in Disenfranchised Communities: A Multicenter Study during COVID-19 Pandemic

et al. 2023

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“…No significant relationship was observed between the variables. The prevalence of LTBI among hemodialysis patients was reported in several studies (8,9,(17)(18)(19)(20)(21)(22)(23)(24)(25)(26), with a recent meta-analysis ( 27) reporting a pooled prevalence of 34.8% (95%CI; 29.1,-40.5). Specifically for Iran, two of the previous reports indicated the prevalence of LTBI to be between 19.6-25.5% (25,26), while one study reported a high prevalence of 81.5% (21), which should be interpreted in light of their limitations.…”

Section: Discussionmentioning

confidence: 98%

Prevalence and risk factors of latent tuberculosis infection in hemodialysis patients in southwest Iran

Rahimi,

Forouzani,

Mousavizadeh

et al. 2024

Przegl Epidemiol

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INTRODUCTION. Tuberculosis (TB) is a significant global health concern, particularly in developing countries. Diagnosing latent tuberculosis infection (LTBI) in hemodialysis patients is crucial because of the risk of developing active tuberculosis in this population due to attenuated immune response. Herein, we assessed the prevalence of LTBI in hemodialysis patients. METHODS. In this cross-sectional study, we included all patients referred to hemodialysis centers in Kohgiluyeh and Boyer-Ahmad Province, southwest Iran, in 2018 through census sampling. Tuberculin skin test (TST) was utilized to screen the patients for LTBI. All steps were done by trained physicians. RESULTS. In total, 183 patients (mean age: 59.3, SD= 16.0) were included in the study of which 76 (41.5%) were females, and 107 (58.5%) were males. Neither the patients nor their family members had a history of tuberculosis. Assuming an above 5-millimeter enduration as a positive TST result, 22 patients (12%) had LTBI. None of the demographic or clinical features differed between TST -negative and -positive groups. CONCLUSION. Hemodialysis patients are prone to LTBI due to several immunological and environmental factors. Screening for LTBI may be beneficial to prevent active tuberculosis in this population.

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Detection of latent tuberculosis infection in hemodialysis patients: Comparison between the quantiferon-tuberculosis gold test and the tuberculin skin test

Cited by 2 publications

References 31 publications

Prevalence of Latent Tuberculosis Infection among Patients Undergoing Regular Hemodialysis in Disenfranchised Communities: A Multicenter Study during COVID-19 Pandemic

Prevalence of Latent Tuberculosis Infection among Patients Undergoing Regular Hemodialysis in Disenfranchised Communities: A Multicenter Study during COVID-19 Pandemic

Prevalence and risk factors of latent tuberculosis infection in hemodialysis patients in southwest Iran

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