Detection of interleukin-6 in vaginal secretions of women with preterm premature rupture of membranes and its association with neonatal infection: A rapid immunochromatographic test

Kayem, Gilles; Goffinet, François; Batteux, Frédéric; Jarreau, Pierre Henri; Weill, Bernard; Cabrol, D.

doi:10.1016/j.ajog.2004.07.015

Cited by 34 publications

(21 citation statements)

References 16 publications

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“…Kayem et al [23] reported that >20 mg/dl of CRP level predicted neonatal infection with 21% sensitivity, 95% specificity, 50% PPV and 84% NPV. Torbe [24] found the CRP level cutoff to be ≥ 10 mg/dl with 52% sensitivity, 76% specificity, 52% PPV and 76% NPV in predicting EONS.…”

Section: Discussionmentioning

confidence: 99%

Is Maternal Blood Procalcitonin Level a Reliable Predictor for Early Onset Neonatal Sepsis in Preterm Premature Rupture of Membranes?

Çetin¹,

Aydın²,

Verit³

et al. 2016

Gynecol Obstet Invest

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Background: This study is aimed at comparing the early diagnostic accuracy of maternal blood white blood cell (WBC) count, C-reactive protein (CRP) and procalcitonin in predicting early onset neonatal sepsis (EONS) among early preterm premature rupture of membrane (PPROM) pregnancies. Methods: A total of 57 consecutive pregnancies, complicated with PPROM, between 24 and 34 gestational weeks were recruited to the study at Suleymaniye Maternity Education and Research Hospital, Istanbul, Turkey between January 2012 and January 2013. All patients were hospitalized and followed up with expectant management. Maternal blood WBC count, CRP and procalcitonin levels were measured in the first 12 h of membrane rupture. EONS was diagnosed using clinical and laboratory findings, and obstetric and neonatal outcomes were noted. Results: The cutoff value for maternal blood CRP was ≥9.49 mg/dl. This value predicted EONS with 77.8% sensitivity, 80.0% specificity, 77.8% positive predictive value (PPV) and 80.0% negative predictive value (NPV). The cutoff value for maternal blood procalcitonin was 0.071 ng/ml. This value predicted EONS with 85.2% sensitivity, 86.7% specificity, 85.2% PPV and 86.7% NPV. Conclusion: Maternal blood procalcitonin levels were superior to maternal blood CRP and WBC count in predicting EONS. Consequently, the maternal blood procalcitonin level is a clinically useful, non-invasive and reliable biomarker in antenatal prediction of EONS.

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Section: Discussionmentioning

confidence: 99%

Is Maternal Blood Procalcitonin Level a Reliable Predictor for Early Onset Neonatal Sepsis in Preterm Premature Rupture of Membranes?

Çetin¹,

Aydın²,

Verit³

et al. 2016

Gynecol Obstet Invest

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“…Yoon et al 12 noticed that mothers with pPROM, delivering newborns with significant morbidity, had significantly higher median CRP concentration than mothers delivering newborns without significant complications (6.5 versus 2.0 mg l -1 ). Kayem et al 2 observed that elevated maternal serum CRP concentration in patients with pPROM between 24 and 34 weeks gestation was associated with neonatal infection. In their study, the relatively high cutoff value of >20 mg l -1 predicted congenital infection with a sensitivity of 21%, a specificity of 95%, a PPV of 50%, and an NPV of 84%.…”

Section: Discussionmentioning

confidence: 99%

“…Antenatal detection of neonatal infection would also enable the physicians to more accurately select the population of newborn infants that require antibiotic treatment. 2,[5][6][7][8] Therefore, there is a need for the development of sensitive tests for the prediction of inborn infection that are of value in the management of the immediate neonatal period. 4,9 Maternal serum is an easily reachable biological material that is collected in almost noninvasive way.…”

Section: Introductionmentioning

confidence: 99%

“…1 Microbial invasion of the amniotic cavity is present in about 50% of pPROM cases, and neonates from pPROM-affected pregnancies are at higher risk of infection-related morbidity. 2,3 Prompt diagnosis of intraamniotic infection, which usually is subclinical, is necessary for the application of the proper pattern of clinical management. To determine whether the patient has intraamniotic inflammation, and thus should be delivered rather than managed expectantly or even treated with tocolytic agents, is often a critical decision with clinical implications for both mother and fetus.…”

Section: Introductionmentioning

confidence: 99%

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Maternal serum and vaginal fluid C-reactive protein levels do not predict early-onset neonatal infection in preterm premature rupture of membranes

Torbé

Kowalski

2010

J Perinatol

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Objective: The aim of this study was to evaluate the usefulness of maternal serum and vaginal fluid C-reactive protein (CRP) determinations in the prediction of neonatal congenital infection.Study Design: Fifty women between 24 and 36 weeks gestation, complicated by preterm premature rupture of membranes (pPROM), were divided into two groups according to the presence (n ¼ 14) or absence (n ¼ 36) of early-onset newborns' infection.Result: Maternal serum and vaginal fluid CRP concentrations were comparable between both groups. Serum CRP levels X10 and X15 mg l -1 predicted neonatal infection with a sensitivity of 47 and 47%, specificity of 63 and 76%, positive predictive value (PPV) of 38 and 47%, and negative predictive value (NPV) of 72 and 76%, respectively. The cutoff value of vaginal CRP X2.4 mg l -1 predicted infection with a sensitivity of 71%, specificity of 47%, PPV of 34%, and NPV of 81%. Receiver-operating characteristic curve analysis revealed that the predictive performance of CRP was poor.Conclusion: Maternal serum and vaginal fluid CRP determinations after pPROM are of poor predictive value in neonatal early-onset infection prediction.

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“…Many possible markers of early infection have been investigated so far, yielding variable results, in search of a rapid, specific and sensitive test that would ensure early treatment and reduce unnecessary prophylactic treatment (3,4,5,6). Many humoral factors, recently even contents of their mRNA, have been measured, attempting to discover the immune reaction as early as possible.…”

Section: Discussionmentioning

confidence: 99%

Surface Activation Leukocyte Markers and Humoral Factors in Cord Blood of Newborns at Risk of Early Infection

Rozsíval

Parízková

Vokurková

et al. 2007

Acta Med. (Hradec Kralove, Czech Repub.)

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Summary: Due to immaturity of both specific and non-specific immune mechanisms, neonates are at risk of serious infections. The risk group definition is vague, clinical signs are non-specific and common laboratory markers are not as useful as in later ages, especially due to delayed reactions. In an attempt to find early, sensitive and specific markers, we assessed a defined set of surface leukocyte markers and humoral factors in cord blood. Several differences were noted -children in the risk group had a higher proportion of CD19+/23+, CD16+/64+, CD45RO cells and higher levels of IL-6. We find it promising that already at birth there are notable signs of reaction to infection and that a follow-up of a set of infectious markers could be useful to identify the children in need of antibiotic treatment and for diminishing unnecessary treatment.

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Detection of interleukin-6 in vaginal secretions of women with preterm premature rupture of membranes and its association with neonatal infection: A rapid immunochromatographic test

Cited by 34 publications

References 16 publications

Is Maternal Blood Procalcitonin Level a Reliable Predictor for Early Onset Neonatal Sepsis in Preterm Premature Rupture of Membranes?

Is Maternal Blood Procalcitonin Level a Reliable Predictor for Early Onset Neonatal Sepsis in Preterm Premature Rupture of Membranes?

Maternal serum and vaginal fluid C-reactive protein levels do not predict early-onset neonatal infection in preterm premature rupture of membranes

Surface Activation Leukocyte Markers and Humoral Factors in Cord Blood of Newborns at Risk of Early Infection

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