2004
DOI: 10.1016/j.ijantimicag.2004.04.009
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Detection of integrons and antibiotic-resistance genes in Salmonella enterica serovar Typhimurium isolates with resistance to ampicillin and variable susceptibility to amoxicillin-clavulanate

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Cited by 29 publications
(21 citation statements)
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References 29 publications
(30 reference statements)
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“…A total of 75.1% of the isolates were recovered from the young and middle-aged population. This is different from what had been reported previously for Typhimurium infection in Spain and enteric fever in India, where most of the isolates (76% and 90.2%, respectively) were recovered from children [3,4]. Humans may be exposed to Salmonella through consumption of contaminated water and food [5].…”
Section: Discussioncontrasting
confidence: 76%
“…A total of 75.1% of the isolates were recovered from the young and middle-aged population. This is different from what had been reported previously for Typhimurium infection in Spain and enteric fever in India, where most of the isolates (76% and 90.2%, respectively) were recovered from children [3,4]. Humans may be exposed to Salmonella through consumption of contaminated water and food [5].…”
Section: Discussioncontrasting
confidence: 76%
“…Production of enzymes due to extended-spectrum cephalosporinases has been observed in S. Choleraesuis resistance, and most of the isolates in this study were found to display this property with cephalothin (Table 3) [51]. This is an indication that the isolates could be harboring cefotaximehydrolyzing β-lactamases (CTX-M types) or CMY-2 AmpC β-lactamase that could hydrolyze cephalosporins normally transferred through conjugative plasmids, transposons, or integrons [52,53]. This is supported by the fact that resistance to β-lactams in S. enterica is primarily caused by the production of acquired β-lactamases [54], with TEM-1, PSE-1, and OXA-1 having been described as the enzymes most frequently related to ampicillin and amoxicillin/clavulanate resistance.…”
Section: Discussionmentioning
confidence: 74%
“…Sin embargo, en los últimos años se está observando un cambio, con cifras superiores para el serotipo Typhimurium 5-8 . La importancia de esta modificación radica en el perfil de sensibilidad, pues el serotipo Typhimurium se relaciona con mayores tasas de resistencia y multirresistencia antibiótica 6,9 . La resistencia a ampicilina y amoxicilina-clavulánico en SNT se atribuye a ␤-lactamasas plasmídicas clásicas, entre las que TEM-1, PSE-1 y OXA-1 son las más frecuentes, aunque las 2 últimas parecen quedar más limitadas al serotipo Typhimurium 6,10,11 .…”
Section: Salmonella Enterica No Typhiunclassified