“…7,15,16 In relation to the information obtained by SC-ICP-MS, it can be limited to get qualitative information, as in the monitoring of essential elements (Mg, P, Mn, Cu, Se or Zn) in single yeast cells (Saccharomyces cerevisiae) 17,18 or to the detection of endogenous and exogenous elements (Mg, P, K, Cr, Zn and Pt) in single sperm cells. 19 However, many studies provide quantitative information derived from SC-ICP-MS whose validity should be evaluated conveniently, which is not always the case. [20][21][22] Comparison of the SC-ICP-MS results with those from the acid digested cells is the most frequent strategy, although signicant differences have been reported for the analysis of a number of cells, algae, protozoa and yeasts.…”